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1.
Lasers Med Sci ; 24(2): 234-40, 2009 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-18418643

RESUMO

The aim of the investigation was to assess histologically the effect of laser photobiomodulation (LPBM) on a repair of defects surgically created in the femurs of rats. Forty-five Wistar rats were divided into four groups: group I (control); group II (LPBM); group III (hydroxyapatite guided bone regeneration; HA GBR); group IV (HA GBR LPBM). The animals in the irradiated groups were subjected to the first irradiation immediately after surgery, and it was repeated every day for 2 weeks. The animals were killed 15 days, 21 days and 30 days after surgery. When the groups irradiated with implant and membrane were compared, it was observed that the repair of the defects submitted to LPBM was also processed faster, starting from the 15th day. At the 30th day, the level of repair of the defects was similar in the irradiated groups and those not irradiated. New bone formation was seen inside the cavity, probably by the osteoconduction of the implant, and, in the irradiated groups, this new bone formation was incremental. The present preliminary data seem to suggest that LPMB therapy might have a positive effect upon early wound healing of bone defects treated with a combination of HA and GBR.


Assuntos
Materiais Biocompatíveis/uso terapêutico , Regeneração Óssea/efeitos da radiação , Durapatita/uso terapêutico , Fêmur/patologia , Regeneração Tecidual Guiada/métodos , Terapia com Luz de Baixa Intensidade , Animais , Terapia Combinada , Feminino , Fêmur/fisiopatologia , Fêmur/efeitos da radiação , Masculino , Ratos , Ratos Wistar
2.
Photomed Laser Surg ; 26(2): 167-74, 2008 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-18341420

RESUMO

OBJECTIVE: This study assessed histologically the effect of laser photobiomodulation on the repair of surgical defects created in the femurs of Wistar rats treated or not treated with bone morphogenetic proteins (BMPs) and organic bovine bone graft. BACKGROUND DATA: This paper is part of an ongoing series of works in which biomaterials and/or guided bone regeneration (GBR) are used in association with laser photobiomodulation. Several previous reports from our group have shown that the use of laser photobiomodulation improves the treatment of bone defects. MATERIALS AND METHODS: Forty-eight adult male Wistar rats were divided into four randomized groups: group 1 (controls, n = 12); group 2 (laser photobiomodulation, n = 12); group 3 (BMPs + organic bovine bone graft + GBR, n = 12); and group 4 (BMPs + organic bovine bone graft + GBR + laser photobiomodulation, n = 12). The irradiated groups received seven irradiations every 48 h, the first immediately after the surgical procedure. Laser photobiomodulation (830 nm, 40 mW, CW, phi approximately 0.6 mm) consisted of a total of 16 J/cm2 per session at four points (4 J/cm2 each) equally spaced around the periphery of the defect. The animals were sacrificed after 15, 21, and 30 d, and the specimens were routinely embedded in wax and stained with hematoxylin and eosin and Sirius red stains and analyzed under light microscopy. RESULTS: The results showed histological evidence of increased deposition of collagen fibers (at 15 and 21 d), as well as an increased amount of well-organized bone trabeculi at the end of the experimental period (30 d) in irradiated animals compared to non-irradiated controls. CONCLUSION: We concluded that the use of laser photobiomodulation in association with BMPs, organic bovine bone grafts, and GBR increases the positive biomodulating effects of laser energy.


Assuntos
Proteínas Morfogenéticas Ósseas/uso terapêutico , Regeneração Óssea/efeitos da radiação , Fêmur/fisiopatologia , Fêmur/efeitos da radiação , Regeneração Tecidual Guiada/métodos , Terapia a Laser , Animais , Materiais Biocompatíveis/uso terapêutico , Regeneração Óssea/efeitos dos fármacos , Feminino , Fêmur/lesões , Masculino , Ratos , Ratos Wistar
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