RESUMO
The antibiotic sensitivity of 113 strains of N. gonorrhoeae collected in Kingston and Montego Bay in 1978 was compared to that of 26 strains collected in Kingston in 1971. In 1971, 38 percent of the gonococcal isolates in Jamaica grew in the presence of >0.25 æg/ml of penicillin (0.4 units) compared to only 8.9 percent in 1978. A similar decrease in the level of tetracycline resistance (MIC>1.0 æg/ml) was also seen from 1971, when 31 percent of gonococcal isolates were resistant, to 1977 when only 13.4 percent were resistant. The percentage of antibiotic resistance of strains of N. gonorrhoeae in Jamaica was higher than were contemporary isolates from the United States in both 1971 and 1978. The level of penicillin and tetracycline resistance of the 1978 strains were less than those of the 1971 strains, but were higher as a group than contemporary gonococci isolated in the United States (AU)
Assuntos
Feminino , Humanos , Técnicas In Vitro , Masculino , Neisseria gonorrhoeae/efeitos dos fármacos , Penicilinas/farmacologia , Tetraciclina/farmacologia , Resistência Microbiana a Medicamentos , Testes de Sensibilidade Microbiana , Jamaica , Estados UnidosRESUMO
The investigation on siblings of AGN patients has shown a streptococcus carrier evidence of 45%, while glomerulonephritis incidence was 15%. These data allowed us to classify our population as highly susceptible to bacterial dissemination and to the development of non-suppurative complications. Renal compromise was clinical and histologically classified. Subclinical forms showed glomerular lesions of mesangial localization, while clinical forms exhibited variable degrees of cellular proliferation. All patients recovered except one who died of a rapidly progressive form.
Assuntos
Glomerulonefrite/etiologia , Infecções Estreptocócicas/complicações , Adolescente , Biópsia , Portador Sadio/epidemiologia , Criança , Pré-Escolar , Colômbia , Feminino , Glomerulonefrite/epidemiologia , Glomerulonefrite/genética , Glomerulonefrite/patologia , Humanos , Glomérulos Renais/patologia , Masculino , Infecções Estreptocócicas/epidemiologiaRESUMO
El estudio de una poblacion de hermanos de pacientes con glomerulonefritis aguda mostro una incidencia de portadores de estreptococo del 45% mientras que la frecuencia de glomerulonefritis fue del 15%. Estos datos permiten clasificar a nuestra poblacion como altamente susceptible a la diseminacion de esta bacteria y el desarrollo de sus complicaciones no supurativas. El compromiso renal fue caracterizado clinica e histologicamente en las diferentes formas de presentacion. Las formas subclinicas presentaron lesiones glomerulares de localizacion mensangial mientras que las formas clinicas mostraron grados variables de proliferacion celular. Con excepcion de un paciente que murio con una forma rapidamente progresiva, todos evolucionaron hacia una curacion aparentemente definitiva
Assuntos
Glomerulonefrite , Infecções EstreptocócicasRESUMO
The sensitivity of penicillin and tetracycline of 53 strains of gonococci isolated in the Summer of 1971 from routine cases in a clinic in Kingston, Jamaica, has been determined. The level of sensitivity of Jamaican strains to these antibiotics was remarkably similar to the sensitivity to these antibiotics of routine strains isolated over the United States in 1970-71. There was a remarkable correlation of sensitivities to penicillin and tetracycline of individual strains. The similarity of sensitivity of strains in Jamaica to the sensitivity of strains in the United States and the good correlation of the degree of sensitivity of individual strains to the two drugs lend support to the hypothesis of Sparling (1972) and of Maness and Sparling (1973) of a common genetic pathway responsible for the development of most cases of resistance to these antibodies (AU)