RESUMO
Although thyroid cancer represents less than 1% of malignant tumours, its increased incidence detected in recent years and the appearance and development of new drugs targeting specific molecular targets has attracted the attention of the doctors involved in this pathology, especially medical oncologists. For this reason it is important at this critical point, when treatment may be substantially changed, to establish and agree updated guidelines. These guidelines should incorporate the newly developed strategies that, although still preliminary in evidence level, will surely have an important role, especially in relapsed and refractory tumours, which are unsuitable for surgical or radio-iodine treatment. Particular histological and molecular features of these tumours must be taken into account in order to optimise therapeutic approaches.
Assuntos
Carcinoma Medular/terapia , Oncologia/métodos , Neoplasias da Glândula Tireoide/terapia , Adulto , Carcinoma Medular/diagnóstico , Humanos , Pessoa de Meia-Idade , Estadiamento de Neoplasias/métodos , Sociedades Médicas , Neoplasias da Glândula Tireoide/diagnóstico , Resultado do TratamentoRESUMO
Gastrointestinal stromal tumours (GIST) are the most common mesenchymal neoplasm of the gastrointestinal tract. Rectum localisation is infrequent for these neoplasms, accounting for about 5% of all cases. Distant metastases of GIST are also rare. We present a patient with special features: the tumour is localised in rectum and it has an uncommon metastatic site, the skull, implying a complex differential diagnosis approach.