RESUMO

Fimose em cães é uma afecção pouco frequente, caracterizada pela incapacidade de exposição do pênis. Ascausas são diversas e incluem falha no desenvolvimento prepucial, trauma, neoplasia ou celulite prepucial.Este trabalho tem como objetivo relatar o caso de um cão de quatro meses de idade com histórico deestrangúria e aumento de volume prepucial. Baseado no histórico, e achados do exame físico diagnosticou--se fimose congênita, sendo submetido à correção cirúrgica. Uma pequena porção circular do prepúciocranioventral foi removida e a mucosa prepucial foi suturada à pele em padrão interrompido simples. Oprocedimento foi rápido e simples de ser realizado, resultando na completa remissão dos sinais clínicos.

Phimosis in dogs is a rare condition characterized by the inability to expose the penis. The causesare diverse and include development failure, preputial trauma, neoplasia or preputial cellulite. Thisstudy aims to report the case of a four-month old dog with a history of urine retention and drippingand preputial swelling. Based on history and physical examination, the patient was diagnosed withcongenital phimosis and underwent surgical correction. A small circular portion of the cranial prepucewas removed and preputial mucosa was sutured to the skin in a simple interrupted pattern.The procedure was quick and simple to perform, resulting in complete remission of clinical signs.

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RESUMO

Fimose em cães é uma afecção pouco frequente, caracterizada pela incapacidade de exposição do pênis. Ascausas são diversas e incluem falha no desenvolvimento prepucial, trauma, neoplasia ou celulite prepucial.Este trabalho tem como objetivo relatar o caso de um cão de quatro meses de idade com histórico deestrangúria e aumento de volume prepucial. Baseado no histórico, e achados do exame físico diagnosticou--se fimose congênita, sendo submetido à correção cirúrgica. Uma pequena porção circular do prepúciocranioventral foi removida e a mucosa prepucial foi suturada à pele em padrão interrompido simples. Oprocedimento foi rápido e simples de ser realizado, resultando na completa remissão dos sinais clínicos.AU

Phimosis in dogs is a rare condition characterized by the inability to expose the penis. The causesare diverse and include development failure, preputial trauma, neoplasia or preputial cellulite. Thisstudy aims to report the case of a four-month old dog with a history of urine retention and drippingand preputial swelling. Based on history and physical examination, the patient was diagnosed withcongenital phimosis and underwent surgical correction. A small circular portion of the cranial prepucewas removed and preputial mucosa was sutured to the skin in a simple interrupted pattern.The procedure was quick and simple to perform, resulting in complete remission of clinical signs.AU

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Background: Biological membranes demonstrate superiority over synthetic ones for its biocompatibility and strength in the reduction of abdominal hernias. Recents tissue engineering researches add mesenchymal stem cells to biological membranes with the purpose of obtaining additional cellular proliferation and consequent muscle regeneration, using biological membranes as cellular scaffolds. This article aimed to study the influence of mesenchymal stem cells in muscle regeneration in abdominal hernias, reduced with biological membranes. Materials, Methods & Results: Adult Wistar rats underwent abdominal hernia-inducing. They were divided into two groups as to the form of treatment for the reduction of hernia: stem cells associated with biological membranes or only biological membranes. After the treatment the macro and microscopic reviews were carried out in days seven, 14 and 60 postoperatively. Preparation of bovine pericardium with glycerin 98% presented efficiency in decellularization and conservation, maintaining its strength and avoiding bacterial growth. The mesenchymal stem cells obtained from bone marrow of adult Wistar rats, had capacity of proliferation. The majority of the cells was positive for the expression of surface antigens CD44, CD29 and CD99 and was negative for CD 34. In the differentiation trials, the same cells were able to differentiate into adipocytes and osteocytes. With 24 h from co-cultivating adhesion of mesenchymal stem cells in the membranes was observed. There was no foreign body reaction or contamination of surgical wounds and there was intense postoperative neovascularization on seven days. All animals presented omentum adherence, but no adherence to other organs.There was no statistically difference for the different times in macroscopic assessment: deposition of fibrous tissue, implant integration. The same occurred with the microscopic evaluations between the different treatment groups. The groups of immediate and later repair presented different responses to treatment. Discussion: The use of rats as animal model was satisfactory, being suitable for surgical procedures and assessments of the abdominal cavity. The different results obtained between groups of immediate repair and late repair corroborate with the idea that there is difference between induction and repair models in the same surgery or in different surgeries with the time interval between the two, suggesting the need for methodologies that simulate the hernias chronicity. The cells used were classified as mesenchymal stem cells, because it met all the criteria of Mesenchymal and Tissue Stem Cell Committee of the International Society of Celullar Therapy. The membranes conserved with glycerin 98% demonstrated biocompatibility, because there was no rejection or necrosis, infection or exacerbated infl ammation. However the muscle regeneration was not obtained over the membranes - and the methodological difference in other latest experiments about the membranes decellularization and the co-cultivating - can leads to conclusion that the cells attached to membranes were insufficient in number to obtain the desired result. These results suggest the need of new research studies or co-cultivating times and decellularization methods of bovine pericardium for association with mesenchymal stem cells.

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A enrofloxacina é um antimicrobiano de amplo espectro do grupo das fluorquinolonas, de grande uso em medicina veterinária, sendo ela, droga de escolha no tratamento de diversas doenças. Devido a sua intensa utilização nos gatos e, associada à mudança no esquema de administração e dose, têm-se descrito reações adversas as quais antes não eram observadas. A degeneração retiniana associada ao uso da enrofloxacina em gatos é descrita como sendo aguda, geralmente irreversível. È caracterizada por midríase e posterior cegueira. O exame oftalmoscópico revela degeneração difusa da retina, evidenciado pelo aumento da refletividade da zona tapetal e atenuação dos vasos sanguíneos da retina. Apesar do exato mecanismo da degeneração retiniana induzida pela enrofloxacina não estar bem esclarecida ainda, sugere-se que existam alguns fatores predisponentes como: altas doses da droga ou altas concentrações no plasma; infusão intravenosa rápida de enrofloxacina; longos períodos de tratamento; idade; exposição prolongada à luz solar durante o tratamento; interações medicamentosas e acúmulo da droga devido ao seu metabolismo alterado ou eliminação reduzida. Assim, controlando-se esses fatores, seria possível diminuir as chances da ocorrência de danos à retina felina.

Enrofloxacin is an antimicrobial of broad-spectrum of the group of fluorquinolones, with great use in medicine veterinary, and it is the the drug of choice in the treatment of diverse illnesses. Because its intense use in the cats and, associated to the change in the project of administration and dose, adverse reactions have been described for the first time. The retinal degeneration associate to the use of the enrofloxacin in cats is described as being acute effect, generally irreversible. It is characterized as mydriasis and posterior blindness. Ophthalmoscopic examination discloses diffuse degeneration of retina, evidenced by increase of reflectivity of the tapetal zone and retinal vascular attenuation. Although the exact mechanism of retinal degeneration induced by enrofloxacin is not yet clarified, it is suggested that there are some predisposing factors such as high dosages or high concentrations of the drug in plasma, rapid intravenous infusion of enrofloxacin, long periods of treatment, age, prolonged exposure to sunlight during treatment, drug interactions and accumulation of drugs due to changed or reduced metabolism. Thus, it is possible to reduce the chances of occurrence of damage to the retina feline by controlling these factors.

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