RESUMO
We a case of chronic Aspergillus sp. meningitis in a healthy 43-year-old woman successfully treated with fluconazole given orally (300 ms/day). The diagnosis was made by detection of anti-aspergillus antibodies and positive culture to Aspergillus sp. in the cerebrospinal fluid.
Assuntos
Antifúngicos/uso terapêutico , Aspergilose/tratamento farmacológico , Fluconazol/uso terapêutico , Meningite Fúngica/tratamento farmacológico , Adulto , Anticorpos Antifúngicos/líquido cefalorraquidiano , Aspergilose/líquido cefalorraquidiano , Doença Crônica , Feminino , Humanos , Meningite Fúngica/líquido cefalorraquidianoRESUMO
Cerebral metastases from colorectal adenocarcinomas occur in 8% of the cases. Diagnosis is usually made when primary disease and widespread metastases are already known. We report the case of a patient with single metastases in the pineal region as the first clinical manifestation of a colorectal adenocarcinoma. A 48-year-old female with Parinaud's syndrome for 15 days prior her admission was evaluated in our clinic. She had no symptoms or signs of colorectal disease. MRI examination revealed an heterogeneous lesion with peritumoral gadolinium enhancement, located in the pineal region. The tumor was radically resected through an infratentorial/supracerebellar approach. Histology showed metastatic carcinoma and immunohistochemical examination showed gastrointestinal tract adenocarcinoma. Metastases to the pineal region are extremely rare and should be considered in the differential diagnosis of tumors of this region.