RESUMO
Acute generalized exanthematous pustulosis is an uncommon skin eruption, characterized by fever and the rapid onset of disseminated, non-follicular, sterile pustules, over an erythematous skin background. It is usually classified as a severe cutaneous adverse drug reaction, whose most relevant triggers are antibiotics and anticonvulsants. However, viral and bacterial infections have also rarely been associated with this dermatosis. We report the case of a patient, who developed lesions of acute generalized exanthematous pustulosis as an extrapulmonary manifestation of Mycoplasma pneumoniae infection.
Assuntos
Pustulose Exantematosa Aguda Generalizada/microbiologia , Mycoplasma pneumoniae , Pustulose Exantematosa Aguda Generalizada/patologia , Feminino , Humanos , Pessoa de Meia-IdadeRESUMO
Acute generalized exanthematous pustulosis is an uncommon skin eruption, characterized by fever and the rapid onset of disseminated, non-follicular, sterile pustules, over an erythematous skin background. It is usually classified as a severe cutaneous adverse drug reaction, whose most relevant triggers are antibiotics and anticonvulsants. However, viral and bacterial infections have also rarely been associated with this dermatosis. We report the case of a patient, who developed lesions of acute generalized exanthematous pustulosis as an extrapulmonary manifestation of Mycoplasma pneumoniae infection.
Assuntos
Feminino , Humanos , Pessoa de Meia-Idade , Pustulose Exantematosa Aguda Generalizada/microbiologia , Mycoplasma pneumoniae , Pustulose Exantematosa Aguda Generalizada/patologiaRESUMO
Tuberculosis remains a major global health problem. Cutaneous involvement is a rare manifestation of tuberculosis infection. Sporotrichoid clinical pattern consists of a linear arrangement of nodules along the lymphatic vessels. It is often seen in sporotrichosis. Few cases have been reported of cutaneous tuberculosis presenting as a sporotrichoid clinical pattern. We describe a 84-year-old female with ulcerative nodules on upper extremity caused by Mycobacterium tuberculosis, emphasizing the importance of considering cutaneous tuberculosis in the differential diagnosis of sporotrichoid lesions.
Assuntos
Esporotricose/patologia , Tuberculose Cutânea/patologia , Idoso de 80 Anos ou mais , Diagnóstico Diferencial , Feminino , Humanos , Hospedeiro Imunocomprometido , Mycobacterium tuberculosis/isolamento & purificaçãoRESUMO
Tuberculosis remains a major global health problem. Cutaneous involvement is a rare manifestation of tuberculosis infection. Sporotrichoid clinical pattern consists of a linear arrangement of nodules along the lymphatic vessels. It is often seen in sporotrichosis. Few cases have been reported of cutaneous tuberculosis presenting as a sporotrichoid clinical pattern. We describe a 84-year-old female with ulcerative nodules on upper extremity caused by Mycobacterium tuberculosis, emphasizing the importance of considering cutaneous tuberculosis in the differential diagnosis of sporotrichoid lesions.
En la actualidad, la tuberculosis sigue siendo un problema de salud pública en el mundo. El compromiso cutáneo es una manifestación poco frecuente de la infección por Mycobacterium tuberculosis. El patrón esporotricoide se refiere a la disposición lineal de los nódulos cutáneos siguiendo el trayecto de los vasos linfáticos, forma de presentación característica de la esporotricosis, de ahí su nombre. Muy pocos casos han sido reportados sobre tuberculosis cutánea con patrón esporotricoide. Se presenta el caso clínico de una mujer de 84 años con nódulos ulcerativos de disposición lineal en miembro superior causados por Mycobacterium tuberculosis, destacando la importancia de incluir a la tuberculosis cutánea en el diagnóstico diferencial de lesiones con patrón esporotricoide.
Assuntos
Idoso de 80 Anos ou mais , Feminino , Humanos , Esporotricose/patologia , Tuberculose Cutânea/patologia , Diagnóstico Diferencial , Hospedeiro Imunocomprometido , Mycobacterium tuberculosis/isolamento & purificaçãoRESUMO
INTRODUCTION: Loxoscelism represents a major public health problem for which there are no standard therapeutic interventions. OBJECTIVE: To review available scientific evidence on management of Loxoscelism METHOD: Systematic review of clinical studies. The search included multiple databases (Medline, Lilacs, Embase, Web of Sciences, Cinahl, Pre-Cinahl, Paperfirst, Proceedingsfirst, Dissertations and Theses, Toxline, Cochrane Library), handsearch of references, and contact with experts. RESULTS: Three clinical trials of poor methodological quality were identified from 5,207 references found. One trial (n = 31), concluded that the use of dapsone was associated with fewer local complications than surgical treatment. A second study (n = 46), concluded that the use of dapsone was superior to clorfenamine for skin lesions. A third study (n = 95) concluded that there was no differences between the use of oral dapsone, antivenom against anti-Loxosceles reclusa or a combination of both. CONCLUSIONS: There is insufficient evidence based on good quality studies to recommend treatment guidelines for individuals with skin or visceral loxoscelism.
Assuntos
Dermatopatias/etiologia , Picada de Aranha/complicações , Ensaios Clínicos como Assunto , Medicina Baseada em Evidências , Humanos , Dermatopatias/terapia , Picada de Aranha/terapiaRESUMO
BACKGROUND: Systematic reviews should include as many articles as possible. However, many systematic reviews use only databases with high English language content as sources of trials. Literatura Latino Americana e do Caribe em Ciências da Saúde (LILACS) is an underused source of trials, and there is not a validated strategy for searching clinical trials to be used in this database. OBJECTIVE: The objective of this study was to develop a sensitive search strategy for clinical trials in LILACS. STUDY DESIGN AND SETTING: An analytical survey was performed. Several single and multiple-term search strategies were tested for their ability to retrieve clinical trials in LILACS. Sensitivity, specificity, and accuracy of each single and multiple-term strategy were calculated using the results of a hand-search of 44 Chilean journals as gold standard. RESULTS: After combining the most sensitive, specific, and accurate single and multiple-term search strategy, a strategy with a sensitivity of 97.75% (95% confidence interval [CI]=95.98-99.53) and a specificity of 61.85 (95% CI=61.19-62.51) was obtained. CONCLUSIONS: LILACS is a source of trials that could improve systematic reviews. A new highly sensitive search strategy for clinical trials in LILACS has been developed. It is hoped this search strategy will improve and increase the utilization of LILACS in future systematic reviews.