RESUMO
Background: Laser acupuncture regulates energy flow and restores body fluid metabolism. Objective: To evaluate the effects of the laser acupuncture protocol (LAP) on hepatic and renal metabolism in sedentary people. Methods: Longitudinal, double-blind, and randomized clinical trial with 29 participants, adults, both sexes, sedentary, without pre-existing metabolic diseases, subdivided into control and laser groups. Based on the STandards for Reporting Interventions in Clinical Trials of Acupuncture 2010 guidelines, 10 laser applications (660 nm ±10 nm wavelength, 100 mW power. The irradiation tip has a diameter of 5 mm, which corresponds to an area of 0.19 cm2, totaling a power density of 0.52 W/cm2 and considering the irradiation time of 90 s, the energy density applied was 47.3 J/cm2) were performed on the acupoints of metabolic functions (LR3, SP6, ST36, and LI4) and blood samples were collected for fasting glycemia, lipid profile (HDL, LDL, total cholesterol, and triglycerides), liver function (AST/GOT and ALT/GPT), and renal function (serum creatinine and urea). A repeated measures analysis of variance (ANOVA) with Bonferroni corrected post hoc comparisons was applied to compare statistical differences between groups and times, adopting p < 0.05 as the null hypothesis. Results: The laser stimulated changes in serum lipid profile values and renal and hepatic functions. There was a significant (p = 0.014) reduction in LDL ("bad" cholesterol) from 105.75 ± 32.83 pre- to 84.32 ± 18.38 mg/dL postintervention, associated with cardioprotective function. Positive significant (p = 0.035) impacts were also observed in the reduction of creatinine (0.86 ± 0.12 mg/dL to 0.75 ± 0.12 mg/dL) and the enzyme AST/GOT (33.73 ± 12.95 U/L to 20.80 ± 4.99 U/L, p = 0.002). Conclusion: LAP applied to basal metabolism acupoints promoted positive metabolic changes in the lipid profile (LDL), and in main markers of the liver (AST/GOT) and kidney (creatinine) functions, contributing to risk control of cardiovascular diseases.
RESUMO
OBJECTIVE: To correlate health-related quality of life (HRQL) of women with COPD with clinical parameters and with the six-minute walk distance (6MWD; six-minute walk test). METHODS: Cross-sectional study involving 30 female patients diagnosed with mild or moderate COPD treated at the Respiratory Outpatient Clinic of the Presidente Dutra University Hospital. Patients completed the Saint George's Respiratory Questionnaire (SGRQ) and were evaluated in terms of respiratory pressures, spirometry parameters and 6MWD. Descriptive statistical analysis was carried out, as were Student's t-tests for dependent variables, together with Pearson's and Spearman's correlation coefficients for numerical and ordinal variables, respectively. RESULTS: According to the SGRQ total scores, HRQL was impaired, to some extent, in most of the participants. Most SGRQ total scores were between the second and the third quartiles, reflecting poor HRQL. The participants also presented poor functional capacity. Mean 6MWD (317.7 m), inspiratory muscle strength (-53.48 cmH2O) and expiratory muscle strength (69.5 cmH2O) were all below reference values. We found that HRQL was not correlated with body mass index or pulmonary function. However, HRQL presented a negative linear correlation with age, MIP and 6MWD, as well as a positive correlation with the sensation of dyspnea and fatigue. CONCLUSIONS: In this study, HRQL, determined using the SGRQ, was severely impaired in COPD patients, who presented severe limitations in functional capacity, breath control and personal life.
Assuntos
Nível de Saúde , Doença Pulmonar Obstrutiva Crônica/fisiopatologia , Qualidade de Vida , Idoso , Dispneia/diagnóstico , Métodos Epidemiológicos , Teste de Esforço , Fadiga/diagnóstico , Feminino , Humanos , Espirometria , CaminhadaRESUMO
OBJETIVO: Correlacionar a qualidade de vida relacionada à saúde (QVRS) de mulheres portadoras de DPOC com parâmetros clínicos e com a distância percorrida no teste de caminhada de seis minutos (TC6). MÉTODOS: Estudo transversal com 30 mulheres portadoras de DPOC leve ou moderada, atendidas no Ambulatório de Pneumologia do Hospital Universitário Presidente Dutra. Foi aplicado o Saint George's Respiratory Questionnaire (SGRQ), assim como foram realizadas as medidas das pressões respiratórias, da espirometria e dos resultados do TC6. Executou-se a análise estatística descritiva, assim como o teste t de Student para variáveis dependentes, o coeficiente linear de Pearson para correlações de variáveis numéricas e o de Spearman para variáveis ordinais. RESULTADOS: A QVRS esteve, na grande maioria das mulheres entrevistadas, comprometida, em graus variados, de acordo com o escore total do SGRQ. Os escores totais do SGRQ da maioria das participantes estavam entre o segundo e o terceiro quartil, o que reflete baixa QVRS. As participantes apresentaram ainda baixa capacidade funcional no TC6, com distância média percorrida (317,7 m) e força muscular inspiratória (-53,48 cmH2O) e expiratória (69,5 cmH2O) abaixo dos valores de normalidade. Não houve correlação entre a QVRS e o índice de massa corpórea e a função pulmonar. No entanto, houve correlação linear negativa com a idade, a PImáx e o TC6 e correlação positiva com a sensação de dispneia e de fadiga. CONCLUSÕES: A QVRS medida pelo SGRQ das pacientes com DPOC desta pesquisa esteve muito comprometida, de modo a provocar limitações graves na funcionalidade, no controle da respiração e na vida pessoal.
OBJECTIVE: To correlate health-related quality of life (HRQL) of women with COPD with clinical parameters and with the six-minute walk distance (6MWD; six-minute walk test). METHODS: Cross-sectional study involving 30 female patients diagnosed with mild or moderate COPD treated at the Respiratory Outpatient Clinic of the Presidente Dutra University Hospital. Patients completed the Saint George's Respiratory Questionnaire (SGRQ) and were evaluated in terms of respiratory pressures, spirometry parameters and 6MWD. Descriptive statistical analysis was carried out, as were Student's t-tests for dependent variables, together with Pearson's and Spearman's correlation coefficients for numerical and ordinal variables, respectively. RESULTS: According to the SGRQ total scores, HRQL was impaired, to some extent, in most of the participants. Most SGRQ total scores were between the second and the third quartiles, reflecting poor HRQL. The participants also presented poor functional capacity. Mean 6MWD (317.7 m), inspiratory muscle strength (-53.48 cmH2O) and expiratory muscle strength (69.5 cmH2O) were all below reference values. We found that HRQL was not correlated with body mass index or pulmonary function. However, HRQL presented a negative linear correlation with age, MIP and 6MWD, as well as a positive correlation with the sensation of dyspnea and fatigue. CONCLUSIONS: In this study, HRQL, determined using the SGRQ, was severely impaired in COPD patients, who presented severe limitations in functional capacity, breath control and personal life.