RESUMO
Se presenta un caso de cromomicosis producido por el Fonsecaea pedrosoi que debido al largo tiempo de evolución antes de la primera consulta y por lo tanto la imposibilidad de realizar un diagnóstico precoz; la resistencia del agente causal a los diferentes tratamientos y, el cumplimiento indebido de los mismos, llevó a la amputación del miembro afectado. Se hace una revisión de la literatura acerca de la epidemiología, clínica, diagnóstico, y tratamiento de la cromomicosis. Se resalta la necesidad de hacer un diagnóstico precoz
Assuntos
Cromoblastomicose/patologia , Criocirurgia/terapia , Fluoracetatos/terapiaRESUMO
cDNA libraries, representative of potato viruses X (PVXc strain) and Y (PVY degrees strain) genomes were obtained. A PVX cDNA cloned fragment was sequenced and biotinylated to be used as hybridization probe for the detection of purified virus or nucleic acid extracts of infected plants. Dot hybridization assay was sensitive to detect 4 ng of viral particles, corresponding to about 200 pg of viral RNA. The level of detection in infected plant extracts was as effective as that obtained with the ELISA. The presence of biotinylated PVY cDNA in the hybridization mixture did not affect sensitivity of the PVX detection assay, suggesting that a single diagnostic assay for several potato viruses and virus-related pathogens could be developed.
Assuntos
Sondas de DNA , Hibridização de Ácido Nucleico , Vírus de Plantas/isolamento & purificação , RNA Viral , Sequência de Aminoácidos , Sequência de Bases , Biotina , DNA , Dados de Sequência Molecular , Vírus de Plantas/genética , RNA Viral/genéticaAssuntos
Pneumopatias Fúngicas/fisiopatologia , Pulmão/fisiopatologia , Paracoccidioidomicose/fisiopatologia , Testes de Função Respiratória , Adulto , Idoso , Antifúngicos/uso terapêutico , Humanos , Pneumopatias Fúngicas/tratamento farmacológico , Pneumopatias Obstrutivas/fisiopatologia , Masculino , Pessoa de Meia-Idade , Paracoccidioidomicose/tratamento farmacológicoRESUMO
Vinte doentes com lesoes pulmonares, difusas causadas pelo Paracoccidioides brasiliensis foram submetidos a provas de funcao pulmonar basicas antes e depois do inicio de tratamento especifico. Apos 1 ou 2 meses de tratamento, a capacidade vital ou a capacidade vital forcada haviam aumentado em mais de 10% em 7 de 19 doentes (36,8%), e a diferenca para o grupo todo foi significativa (P < 0,05). Apos 4 a 10 meses, 5 de 6 doentes apresentaram aumentos superiores a 10% nesse parametro. A evolucao do volume expiratorio forcado em 1 segundo, ou de sua relacao com a capacidade vital, e a da pressao parcial do oxigenio no sangue foi variavel. Estes resultados evidenciam que as provas de funcao pulmonar nao representam meio adequado para o controle do tratamento dessa condicao morbita. Por outro lado, sugerem que os infiltrados pulmonares causados pelo P.brasiliensis tem pouca influencia sobre o componente obstrutivo, que e frequentemente o principal elemento do disturbio funcional na forma pulmonar difusa da paracoccidioidose, mas parece ser causado pela doenca pulmonar obstrutiva cronica frequentemente subjacente
Assuntos
Adulto , Pessoa de Meia-Idade , Humanos , Masculino , Pneumopatias Fúngicas , Paracoccidioidomicose , Testes de Função RespiratóriaRESUMO
Nine patients with sickle cell disease and without concomitant cardiopulmonary illness or acute problems were studied with lung function tests. Besides arterial hemoglobin unsaturation, found in all cases so studied, a slight decrease in PaO2 was also present. The pulmonary gas transfer defect was studied and found to be due mostly to increased right to left shunting, although uneven ventilation/perfusion relationships seem to have been a factor in a few cases. Our data clearly show that the diffusion was not implicated in the gas transfer defect. The clinical implications of this little studied and less mentioned respiratory defect are discussed. Since the defect may enhance the risk of sickling crises, it should be measured in each individual patient, for appropriate prophylactic measures. After accidents, pre and post-operatively and during acute respiratory illness, the defect should be again reevaluated. In all probability many patients will be discovered who represent a respiratory risk, and may require special immunizations, prophylactic antibiotics, professional relocation and, during emergencies, intensive respiratory care.