RESUMO
Eighty patients aged under forty, survivors of an episode of acute myocardial infarction (AMI), were studied by means of angiography. Thirty five had anterior wall infarction, 26 diaphragmatic wall, 9 lateral side and 10 non Q AMI. Tobacco addiction (92% vs 71.9%) and hyperlipemia (34% vs 18.8% were higher (p less than 0.01) that in the total AMI population. They presented an average ejection fraction of 0.56 +/- 0.15 and only in three patients was under 0.30. One, 2 and 3 vessels disease respectively of 43%, 22% and 16%, similar to another series published. A 19% of patients with normal angiography coronaries was seen significantly higher (p less than 0.01) than the observed in AMI in older patients. In conclusion in spite of the good prognosis of this group of patients, is necessary to insist in primary preventive campaigns, mainly against tobacco addiction and hyperlipemia, in order to reduce the frequency of AMI in young people.
Assuntos
Angiografia Coronária , Infarto do Miocárdio/complicações , Infarto do Miocárdio/diagnóstico por imagem , Adulto , Fatores Etários , Feminino , Humanos , Masculino , Infarto do Miocárdio/epidemiologia , Fatores de RiscoRESUMO
Eight patients with typical Prinzmetal's angina and angiography proven coronary artery spasm are reviewed. In all cases the angina pain appeared at rest and was accompanied by a simultaneous ST-segment elevation. The coronary angiography results varied from severe multivessel disease (3 cases) to single vessel disease (3 cases), and normal coronary arteries (2 cases). In all patients a coronary spasm was documented, in five cases induced by ergonovine and in three spontaneously; in all patients but in one, the localization of the spasm was concordant with the ST-segment elevation localization. One case with a severe proximal left anterior descending stenosis was grafted; however the pain was not relieved despite treatment with large amounts of propranolol. This patient died after an episode of severe chest pain. Treatment with nifedipine was given to six patients, with excellent results in four cases, and regular response in two. The main physiopathologic diagnostic and therapeutic aspects of the variant angina syndrome are reviewed.
Assuntos
Angina Pectoris Variante/diagnóstico , Vasoespasmo Coronário/diagnóstico , Idoso , Angina Pectoris Variante/complicações , Angina Pectoris Variante/tratamento farmacológico , Vasoespasmo Coronário/tratamento farmacológico , Vasoespasmo Coronário/cirurgia , Eletrocardiografia , Bloqueio Cardíaco/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Nifedipino/uso terapêutico , Propranolol/uso terapêuticoRESUMO
Presentamos 8 pacientes, todos varones y con edades entre 48 y 65 anos, con un sindrome de dolor precordial tipico de angina variante.En todos ellos pudo demostrarse coronariograficamente un espasmo coronario, siendo en tres espontaneo y en cinco provocado mediante metilergonovina intravenosa. En todos los casos, menos uno, la localizacion del espasmo fue concordante con la de la elevacion del espacio ST durante el dolor. En cinco de los pacientes la nifedipina controlo completamente la crisis a largo plazo, y uno de ellos, que no la tomaba, fallecio en el curso de un episodio de angina severa, a pesar de haber sido intervenido previamente de pontaje aorto-coronario a la descendente anterior con exito. En base a estos hallazgos, revisamos los conocimientos actuales sobre la angina variante, especialmente en sus aspectos fisiopatologico, diagnostico y terapeutico
Assuntos
Angina Pectoris , Fármacos Cardiovasculares , Vasoespasmo Coronário , Angiografia , EletrocardiografiaRESUMO
A 34 year old patient with prolonged unstable angina pectoris who did not respond to medical treatment is presented. In the course of three days he developed acute subendocardial infarction complicated by severe ventricular arrhythmias and cardiac arrest. Previously renovascular arterial hypertension due to important stenosis of the right renal artery had been diagnosed by renal arteriography. The precordial pain did not disappear with acute myocardial infarction. He presented acute postinfarction angina which required the use of vasodilator and beta-adrenergic blocking agents which did not alleviate his symptoms completely. Coronary arteriography performed a month after acute myocardial infarction demonstrated 99% stenosis of the left main coronary artery and 70% stenosis of the left anterior descending artery. During three days before surgery intraaortic ballon pumping was employed and the patient did not present precordial pain. The patient became asymptomatic after placing two aortocoronary vein grafts to the left anterior descending and circumflex arteries, and three months later blood pressure fell to normal after placing a right aorto renal graft. The poor prognosis of critical stenosis of the main left branch, its medical treatment and better evolution after surgery is discussed. The indications for intra-aortic ballon pumping in this type of patients and its use before surgery so as to be able to suspend beta-adrenergic blocking agents without risks are specified. Finally the surgical indications for renovascular hypertension are discussed.
Assuntos
Angina Pectoris/terapia , Hipertensão Renal/terapia , Hipertensão Renovascular/terapia , Obstrução da Artéria Renal/terapia , Adulto , Angina Pectoris/cirurgia , Balistocardiografia , Ponte de Artéria Coronária , Humanos , Hipertensão Renovascular/cirurgia , Masculino , Obstrução da Artéria Renal/cirurgiaRESUMO
Having established an easily reproducible, stable, technique for producing cardiogenic shock in dogs, and for applying the intraaortic balloon pump (IABP), a complementary study was carried out in six dogs that were treated for cardiogenic shock with the IABP associated with 8 micrograms/kg/min. of continuous intravenous dopamine. The results were compared with those obtained using only the IABP. It was found that dopamine associated with the IABP reduced the left ventricular end-diastolic pressure by 75.3% and increased the dP/dt and Vmax by 90% and 41.6% respectively. The heart rate rose from 134 (+/- 2.45) to 153.5 (+/- 14.13) beats per minute two hours after treatment. There were no changes in the mean aortic pressure and left ventricular systolic pressure, and diuresis was decreased. It is concluded that the IABP alone produces a significant decrease in the preload and increase in the afterload, but when associated with dopamine, no changes are observed in the afterload, but the preload falls considerably. Moreover, myocardial contractility is increased. Therefore dopamine and the IABP used together have synergic beneficial effects.
Assuntos
Dopamina/uso terapêutico , Balão Intra-Aórtico , Choque Cardiogênico/terapia , Animais , Terapia Combinada , Cães , Dopamina/farmacologiaRESUMO
Carpentier's ring was inserted in the mitral annulus of 79 patients suffering from mitral valve disease. 49 other patients also underwent surgery on other cardiac valves and are not considered in the present study. The mean follow up time was 19.5 months. The total hospital and late mortality in the isolated ring series was 3.8%. Clinical and hemodynamic improvement was evident postoperatively. The preoperative functional class (NYHA) of the patients was: I, 11.39%; II, 45.5%; III, 34.1%; IV, 8.86% respectively. The postoperative class was: I, 86.8%; II, 7.9%; III, 3.9%; and IV, 1.3% respectively. Postoperative hemodynamic and angiocardiographic evaluation was done in 27 patients. Mean pulmonary artery pressure fell from 49.8 +/- 2.4 mm. Hg to 38 +/- 2 mm. Hg. Mitral regurgitation present preoperatively in 66.6% of cases was present in residual form in only 18.5%. Atrial enlargement was moderate in 42.1% and severe in 57.9% before operation, and 80.3 moderate and 19.7 severe after operation. Tromboembolic accidents occurred in 2 patients (2.2%) both with severe atrial enlargement and atrial fibrillation pre and postoperatively. We conclude that Carpentier's ring is a valid alternative in the surgery of mitral valve disease.
Assuntos
Insuficiência da Valva Mitral/cirurgia , Complicações Pós-Operatórias/diagnóstico , Equipamentos Cirúrgicos , Adolescente , Adulto , Estudos de Avaliação como Assunto , Feminino , Humanos , Masculino , Métodos , Pessoa de Meia-IdadeRESUMO
An experimental study of the production of cardiogenic shock together with the results of its treatment by means of the intraaortic balloon was carried out. Cardiogenic shock was produced in dogs with closed thorax and spontaneous respiration. In 13 of the 21 dogs studied, the production of acute myocardial infarction by means of selective embolism of the left circumflex artery permitted the reproduction of a model of cardiogenic shock. Embolism was produced by injecting metalic mercury through a double catheter. Six of the 8 remaining dogs died due to accidental introduction of mercury in the anterior descending coronary artery which produced irreversible ventricular fibrillation. The other 2 died due to rupture of the ascending aorta during the maneuveres to place the coronarygraphy catheter. The 13 dogs with cardiogenic shock were treated with intraaortic balloon pumping during 3-4 hours. The left ventricular systolic pressure fell from 128 +/- 12.07 to 124 +/- 4.65 mm. Hg. The cardiac index increased by 42%. These findings confirm the fact that intraaortic balloon pumping lessens the after load. The fall of the telediastolic pressure by 20% was an index of the lessening or the preload. The aortic telediastolic pressure rose by a mean value of 32.21 mm. Hg. This raises the coronary perfusion pressure thus limiting the extension or reducing the size of the infarction. A frank reduction of the electrographic subepicardiac lesion was observed after using intraaortic balloon pumping. The mean aortic pressure only rose by 8%, the central venous pressure remained unchanged and the increase in diuresis was not estimable. The maximum dP/dt was unaltered and the Vmax. rose 17%. Two dogs were left alive after the experiment and lived for 3 and 12 days respectively. To conclude the results obtained permit us to indicate that intraaortic balloon pumping when used in dogs with this standard type of cardiogenic shock produces an important reduction of the after load, a discrete reduction of the preload and a significative increase in coronary blood flow. There were no changes in cardiac frequency and although the results of myocardial contractility were not definite, they seem to indicate a moderate improvement.
Assuntos
Cardioversão Elétrica/instrumentação , Infarto do Miocárdio/terapia , Choque Cardiogênico/terapia , Animais , Cães , Hemodinâmica , Manometria , Infarto do Miocárdio/complicações , Pressão , Choque Cardiogênico/etiologiaRESUMO
UNLABELLED: Nineteen dogs in whom an intent to produce cardiogenic shock due to acute myocardial infarction are studied. The dogs are maintained with closed chest and acute myocardial infarction is produced by injecting a bolus of metalic mercury in the left circumflex coronary artery using two different methods. Comparatively, the results show that a more selective embolism is obtained with the double catheter technique than by the introduction of a single coronary arteriograph catheter. Eight of the 19 dogs died. Six due to accidental introduction of mercury in the anterior interventricular artery together with the left circumflex artery, and 2 due to rupture of the ascending aorta during the maneuvre of placing the coronary arteriograph catheter. In the eleven dogs that survived the following parameters were taken every hour during a period of four to six hours. a) Hemodynamic: Left ventricle pressure, cardiac output by thermodilution, maximum dp/dt and Vmax, central venous pressure, cardiac rate and diuresis; b) Metabolic: Gases and lactate in arterial, venous and coronary sinus blood. Cortisol blood levels. All dogs were anaesthetized with thiobarbital during the venous cutdown and later sedated with morfine. They were maintained breathing atmospheric air. Cardiogenic shock was established when the diuresis fell from 170 cc/hour to an average of 43 cc/hour, the mean arterial pressure fell by 20%, the cardiac output by 58%, Vmax descending 20%, the telediastolic pressure of the left ventricle rose from 2.8 mm. Hg to 19.6 mm. Hg and the presence of acidoses was demonstrated by metabolic studies. CONCLUSION: Since the dog is maintained with a closed chest and breathing atmospheric air, this is an excellent method for the production of cardiogenic shock in conditions similar to the humain without the influence of other variables. In this way a better knowledge of shock is obtained and different terapeutic measures can be studied.