RESUMO

Bolivian haemorrhagic fever immunoglobulin of human origin, given either prior to or shortly after experimental infection with Machupo virus, protected rhesus and cynomolgus monkeys against initial clinical illness. Some survivors developed severe neurological signs 30-47 days after virus inoculation and died 4-6 days later. Results from one of the experiments suggested that the development of neurological signs was associated more frequently with high doses of immunoglobulin than with intermediate or low doses.

Assuntos

Febre Hemorrágica Americana/prevenção & controle , Febres Hemorrágicas Virais/prevenção & controle , Imunização , Imunoglobulinas/administração & dosagem , Animais , Anticorpos Antivirais/análise , Arenavirus do Novo Mundo/imunologia , Haplorrinos , Febre Hemorrágica Americana/imunologia , Imunidade Ativa , Macaca fascicularis , Macaca mulatta