RESUMO
Zein, a vegetable protein extracted from corn (Zea mays L.), forms a gastro-resistant and mucoadhesive polymer that is cheap and easy to obtain and facilitates the encapsulation of bioactives with hydrophilic, hydrophobic, and amphiphilic properties. The methods used for synthesizing these nanoparticles include antisolvent precipitation/nanoprecipitation, pH-driven, electrospraying, and solvent emulsification-evaporation methods. Each method has its advantages in the preparation of nanocarriers, nevertheless, all of them enable the production of zein nanoparticles that are stable and resistant to environmental factors, with different biological activities required in the cosmetic, food, and pharmaceutical industries. Therefore, zein nanoparticles are promising nanocarriers that can encapsulate various bioactives with anti-inflammatory, antioxidant, antimicrobial, anticancer, and antidiabetic properties. This article reviews the principal methods for obtaining zein nanoparticles containing bioactives, the advantages and characteristics of each method, as well as the main biological applications of nanotechnology-based formulations.
Assuntos
Nanopartículas , Zeína , Zeína/química , Tamanho da Partícula , Sistemas de Liberação de Medicamentos , Antioxidantes , Nanopartículas/químicaRESUMO
The development of multidrug-resistant (MDR) microorganisms has increased dramatically in the last decade as a natural consequence of the misuse and overuse of antimicrobials. The World Health Organization (WHO) recognizes that this is one of the top ten global public health threats facing humanity today, demanding urgent multisectoral action. The UK government foresees that bacterial antimicrobial resistance (AMR) could kill 10 million people per year by 2050 worldwide. In this sense, metallic nanoparticles (NPs) have emerged as promising alternatives due to their outstanding antibacterial and antibiofilm properties. The efficient delivery of the NPs is also a matter of concern, and recent studies have demonstrated that hydrogels present an excellent ability to perform this task. The porous hydrogel structure with a high-water retention capability is a convenient host for the incorporation of the metallic nanoparticles, providing an efficient path to deliver the NPs properly reducing bacterial infections caused by MDR pathogenic microorganisms. This article reviews the most recent investigations on the characteristics, applications, advantages, and limitations of hydrogels combined with metallic NPs for treating MDR bacteria. The mechanisms of action and the antibiofilm activity of the NPs incorporated into hydrogels are also described. Finally, this contribution intends to fill some gaps in nanomedicine and serve as a guide for the development of advanced medical products.
RESUMO
Medicinal plants have been used for centuries by communities worldwide, as they have diverse biological properties and are effective against numerous diseases. The genus Syagrus stands out for its versatility and for so many activities presented by these palm trees, mainly due to its rich chemical and fatty acid compositions. The genus has antibacterial potential, has antibiofilm, antiparasitic, antioxidant, prebiotic, antiulcerogenic, anticholinesterase, and hypoglycemic activities, and can produce biodiesel, amid others. Among all species, Syagrus coronata and Syagrus romanzoffiana stand out, presenting the greatest number of activities and applications. The secondary metabolites obtained from these palm trees present high activity even in low concentrations and can be used against infections and chronic diseases. Furthermore, these plants have been used in some communities for years and have presented healing properties, especially in inflammatory processes. Therefore, the Syagrus genus proves to be promising, which shows a lot of therapeutic potential.