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Artigo em Espanhol | BINACIS | ID: biblio-1510214

RESUMO

INTRODUCCIÓN: La púrpura de Schönlein Henoch (PSH) es la vasculitis más frecuente de la infancia. Es generalmente autolimitada, con morbilidad renal a largo plazo. OBJETIVO: Determinar la frecuencia de las manifestaciones clínicas de la PSH y las variables asociadas al compromiso renal en pacientes con PSH del Servicio de Reumatología pediátrica de la Clínica Universitaria Reina Fabiola durante el periodo 2015-2020. MATERIALES Y METODOS: Estudio observacional, retrospectivo, transversal, analítico. Se incluyeron pacientes menores de 15 años con diagnóstico de PSH. Variables: edad, sexo, mes de diagnóstico, compromiso dermatológico, renal, gastrointestinal, articular y recurrencia y/o persistencia y otras manifestaciones. Análisis estadístico: test T de Student, test chi cuadrado y regresión logística multivariada. RESULTADOS: Se analizaron 107 pacientes, 61 (57%) de sexo femenino, con una media (desviación estándar, DE) de edad de 6,49 (3,48) años. El 100% presentó compromiso dérmico, 19 (18%) púrpura persistente o recurrente, 21 (19%) síntomas gastrointestinales, 38 (36%) compromiso articular y 21 (20%) manifestaciones renales. Se asoció con compromiso renal a pacientes con edad mayor a 7 años (p=0.0064), púrpura persistente o recurrente (p=0.0001), compromiso articular (p=0,0135) y dolor abdominal (p=0,0136). En el análisis multivariado, la púrpura persistente o recurrente se asoció con compromiso renal (OR=7,16; IC95%: 1,81-28,25); p=0.005). CONCLUSIONES: La púrpura persistente o recurrente fue considerada factor de riesgo para presentar compromiso renal y además se evidenció una asociación entre pacientes mayores a 7 años, compromiso articular y dolor abdominal con compromiso renal.


INTRODUCTION: Schönlein Henoch purpura (SHP) is the most frequent vasculitis in childhood. Its course is generally self-limited but can lead to long-term renal morbidity OBJECTIVE: To determine the frequency of the clinical manifestations of PSH. To determine the variables associated with renal involvement in patients with SHP, treated by the Pediatric Rheumatology Service of the Reina Fabiola University Clinic during the period 2015-2020. MATERIALS AND METHODS: Observational, retrospective, transversal, analytical study. Patients under 15 years of age with a diagnosis of HSP, were included. The variables were: age, sex, month of diagnosis, dermatological, renal, gastrointestinal, joint involvement, recurrence and/or prevalence and other manifestations. Statistical analysis: Student's t test, chi square test and multivariate logistic regression. RESULTS: 107 patients were analyzed, 57% were female (n = 61), with a mean age of 6.49 SD of 3.48 years. 100% presented dermal involvement, 19 (18%) persistent or recurrent purpura, 21 (19%) gastrointestinal symptoms, 38 (36%) joint involvement and 21 (20%) kidney manifestations. An association with kidney involvement was found in patients older than 7 years (p = 0.0064), persistent or recurrent purpura (p = 0.0001), joint involvement (p = 0.0135) and abdominal pain (p = 0.0136), but only persistent or recurrent purpura was the only risk factor associated with statistically significant renal involvement (OR = 71.17; 95% CI = 1.81 - 28.25; P = 0.005). CONCLUSION: Persistent or recurrent purpura was considered a risk factor for the fact of presenting kidney involvement and also an association was evidenced between patients older than 7 years, joint involvement and abdominal pain with kidney involvement.


Assuntos
Masculino , Feminino , Criança , Adolescente , Adulto , Vasculite , Sinais e Sintomas , Criança , Nefropatias/diagnóstico
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