RESUMO
Technological development is key for national strategies to cope with the Paris Agreement's goals. Technology Needs Assessments (TNAs) aim to identify, prioritize, and diffuse climate change mitigation and/or adaptation technologies in developing countries. Their methodology includes a multi-criteria decision analysis (MCDA) framework but, although many countries already conducted a TNA, literature lacks discussions on country-specific processes for a TNA, as it usually follows a one-size-fits-all approach. This paper provides empirical evidence on the importance of country-driven processes that help shaping international programmes into country-specific needs and capabilities. It presents lessons learned from a tailored process for identification, prioritization, and selection of mitigation technologies in the scope of a TNA project for Brazil, an exceptional case of a developing country with strong capacity in integrated assessment modelling (IAM) scenarios for guiding its climate strategies. A previous IAM scenario result allowed pre-selecting technologies in six key economic sectors, while other TNAs prioritized no more than three. This allowed the elaboration of an overall ranking from the MCDA, in contrast to sectoral rankings that are mostly employed in other countries' TNAs. The overall ranking serves not only as a basis for the selection of priority technologies but also provides information on the integrated innovations framework for climate technologies in the country. Further specific findings of the tailored Brazilian TNA approach are discussed in the paper in order to call for the importance that a technology transfer project should not only be country-driven but also conducted through a country-specific process. Supplementary Information: The online version contains supplementary material available at 10.1007/s11027-022-10025-6.
RESUMO
Coronavirus disease 2019 (Covid-19) is an emerging novel respiratory infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that rapidly spread worldwide. In addition to lung injury, Covid-19 patients may develop extrapulmonary symptoms, including cardiac, liver, kidney, digestive tract, and neurological injuries. Angiotensin converting enzyme 2 is the major receptor for the entry of SARS-CoV-2 into host cells. The specific mechanisms that lead to cell death in different tissues during infection by SARS-CoV-2 remains unknown. Based on data of the previous human coronavirus SARS-CoV together with information about SARS-CoV-2, this review provides a summary of the mechanisms involved in cell death, including apoptosis, autophagy, and necrosis, provoked by severe acute respiratory syndrome coronavirus.
Assuntos
COVID-19 , SARS-CoV-2 , Morte Celular , HumanosRESUMO
The accurate prediction of energy requirements for healthy individuals has many useful applications. The occupational perspective has also been proven to be of great utility for improving workers' ergonomics, safety, and health. This work proposes a statistical regression model based on actigraphy and personal characteristics to estimate energy expenditure and cross-validate the results with reference standardized methods. The model was developed by hierarchical mixed-effects regression modeling based on the multitask protocol data. Measurements combined actigraphy, indirect calorimetry, and other personal and lifestyle information from healthy individuals (n = 50) within the age of 29.8 ± 5 years old. Results showed a significant influence of the variables related to movements, heart rate and anthropometric variables of body composition for energy expenditure estimation. Overall, the proposed model showed good agreement with energy expenditure measured by indirect calorimetry and evidenced a better performance than the methods presented in the international guidelines for metabolic rate assessment proving to be a reliable alternative to normative guidelines. Furthermore, a statistically significant relationship was found between daily activity and energy expenditure, which raised the possibility of further studies including other variables, namely those related to the subject's lifestyle.