RESUMO
O hamartoma folicular basaloide (HFB) é um tumor anexial raro e benigno, que se assemelha ao carcinoma basocelular (CBC), e pode apresentar manifestações clínicas diversas. Uma mutação no gene PTCH, envolvido na síndrome de Gorlin-Goltz, poderia estar associada à patogênese dessa neoplasia. Descreve-se caso de menina, sete anos, apresentando múltiplas pápulas na face.
Basaloid follicular hamartoma (BFH) is a rare and benign adnexal tumor that resembles basal cell carcinoma (BCC) and may present with different clinical manifestations. A mutation in the PTCH gene, involved in Gorlin-Goltz syndrome, could be associated with the pathogenesis of this neoplasm. We describe the case of a 7-year-old girl with multiple papules on her face.
Assuntos
Humanos , Feminino , Criança , Dermatoses Faciais/diagnóstico , Hamartoma/diagnóstico , Imuno-Histoquímica , Dermatoses Faciais/patologia , Hamartoma/patologiaRESUMO
Abstract Skin metastases are rare and may occur in the context of a known metastatic disease or be the first clinical sign of an underlying primary tumor. In the case of carcinoid neoplasms, determining whether the cutaneous tumor is primary or secondary and identifying the tumor origin in metastatic cases is not always an easy task. This is the report of a case of cutaneous metastasis presenting as the first clinical manifestation of a previously unknown pulmonary carcinoid tumor, including the discussion of histopathological and immunohistochemical findings that allowed an adequate diagnosis of the tumor etiology and reinforces the importance for dermatologists and dermatopathologists to be familiar with these findings.
Assuntos
Humanos , Neoplasias Cutâneas , Tumor Carcinoide/diagnóstico , Neoplasias PulmonaresRESUMO
Skin metastases are rare and may occur in the context of a known metastatic disease or be the first clinical sign of an underlying primary tumor. In the case of carcinoid neoplasms, determining whether the cutaneous tumor is primary or secondary and identifying the tumor origin in metastatic cases is not always an easy task. This is the report of a case of cutaneous metastasis presenting as the first clinical manifestation of a previously unknown pulmonary carcinoid tumor, including the discussion of histopathological and immunohistochemical findings that allowed an adequate diagnosis of the tumor etiology and reinforces the importance for dermatologists and dermatopathologists to be familiar with these findings.
Assuntos
Tumor Carcinoide , Neoplasias Pulmonares , Neoplasias Cutâneas , Tumor Carcinoide/diagnóstico , HumanosRESUMO
INTRODUCTION: Leprosy recurrence is the reappearance of the disease after treatment with current schemes and discharged for cure and may have variable incubation periods. METHODS: This is a descriptive observational study of leprosy recurrence in Espírito Santo diagnosed between January 2018 and January 2020. RESULTS: One hundred and ninety-two cases were available, of which 30 were diagnosed with leprosy recurrence. CONCLUSIONS: In 25 cases, the incubation period was 5-15 years after the first treatment, favoring bacillary persistence. In the remaining 5 cases, the disease had recurred after 15 years, pointing to reinfection as none of them exhibited drug resistance.
Assuntos
Hanseníase , Brasil , Resistência a Medicamentos , Humanos , Hanseníase/tratamento farmacológico , Recidiva , Centros de Atenção TerciáriaRESUMO
Abstract INTRODUCTION: Leprosy recurrence is the reappearance of the disease after treatment with current schemes and discharged for cure and may have variable incubation periods. METHODS: This is a descriptive observational study of leprosy recurrence in Espírito Santo diagnosed between January 2018 and January 2020. RESULTS: One hundred and ninety-two cases were available, of which 30 were diagnosed with leprosy recurrence. CONCLUSIONS: In 25 cases, the incubation period was 5-15 years after the first treatment, favoring bacillary persistence. In the remaining 5 cases, the disease had recurred after 15 years, pointing to reinfection as none of them exhibited drug resistance.
Assuntos
Humanos , Hanseníase/tratamento farmacológico , Recidiva , Brasil , Resistência a Medicamentos , Centros de Atenção TerciáriaRESUMO
Fusariosis is a superficial or systemic infection, which occurs mainly in immunocompromised hosts, especially in patients with hematological neoplasia; 70%-75% of the cases present cutaneous manifestations. The disseminated form is rare and difficult to diagnose; even with specific treatment, the evolution is usually fatal. Currently, it is considered an emerging disease; in some centers, it is the second most common cause of invasive mycosis, after aspergillosis. The authors describe a case of a female patient with idiopathic bone marrow aplasia and disseminated fusariosis, who initially appeared to benefit from voriconazole and amphotericin B; however, due to persistent neutropenia, her clinical condition deteriorated with fatal evolution.
Assuntos
Fusariose , Fusarium , Antifúngicos/uso terapêutico , Medula Óssea , Feminino , Humanos , Hospedeiro Imunocomprometido , Voriconazol/uso terapêuticoAssuntos
Carcinoma Basocelular/etiologia , Neoplasias Fibroepiteliais/etiologia , Neoplasias Induzidas por Radiação/etiologia , Neoplasias Cutâneas/etiologia , Idoso , Neoplasias Ósseas/radioterapia , Carcinoma Basocelular/patologia , Humanos , Masculino , Neoplasias Fibroepiteliais/patologia , Neoplasias Induzidas por Radiação/patologia , Neoplasias Cutâneas/patologiaAssuntos
Humanos , Masculino , Idoso , Neoplasias Cutâneas/etiologia , Carcinoma Basocelular/etiologia , Neoplasias Fibroepiteliais/etiologia , Neoplasias Induzidas por Radiação/etiologia , Neoplasias Cutâneas/patologia , Neoplasias Ósseas/radioterapia , Carcinoma Basocelular/patologia , Neoplasias Fibroepiteliais/patologia , Neoplasias Induzidas por Radiação/patologiaRESUMO
Leprosy is a chronic neglected and stigmatizing disease. Due to involvement of the peripheral nerves, it can result in physical disabilities, deformities, and emotional damage if not diagnosed and treated promptly. This is the case of a young patient with testicular pain and swelling and no improvement after a specific therapeutic scheme for tuberculosis. Clinical and laboratory reevaluation revealed hypoesthetic skin patches associated with post-burn crusted ulcers on the left arm, thickening of ulnar nerves, atrophy of interosseous muscles of the hands, positive skin smear microscopy, and testicular histopathology with numerous bacilli forming globi. These findings indicated lepromatous leprosy with type II reaction.
Assuntos
Diagnóstico Tardio , Hanseníase Virchowiana/diagnóstico , Doenças Testiculares/tratamento farmacológico , Tuberculose dos Genitais Masculinos/tratamento farmacológico , Úlcera/diagnóstico , Adulto , Braço , Humanos , Hanseníase Virchowiana/complicações , Masculino , Orquite/complicações , Orquite/diagnóstico , Doenças Testiculares/patologia , Tempo para o Tratamento , Úlcera/complicaçõesRESUMO
Abstract Leprosy is a chronic neglected and stigmatizing disease. Due to involvement of the peripheral nerves, it can result in physical disabilities, deformities, and emotional damage if not diagnosed and treated promptly. This is the case of a young patient with testicular pain and swelling and no improvement after a specific therapeutic scheme for tuberculosis. Clinical and laboratory reevaluation revealed hypoesthetic skin patches associated with post-burn crusted ulcers on the left arm, thickening of ulnar nerves, atrophy of interosseous muscles of the hands, positive skin smear microscopy, and testicular histopathology with numerous bacilli forming globi. These findings indicated lepromatous leprosy with type II reaction.
Assuntos
Humanos , Masculino , Adulto , Doenças Testiculares/tratamento farmacológico , Tuberculose dos Genitais Masculinos/tratamento farmacológico , Úlcera/diagnóstico , Hanseníase Virchowiana/diagnóstico , Diagnóstico Tardio , Orquite/complicações , Orquite/diagnóstico , Braço , Doenças Testiculares/patologia , Úlcera/complicações , Hanseníase Virchowiana/complicaçõesAssuntos
Anticoagulantes/efeitos adversos , Deficiência de Proteína S/diagnóstico , Pele/patologia , Trombose Venosa/tratamento farmacológico , Varfarina/efeitos adversos , Adulto , Heparina de Baixo Peso Molecular/uso terapêutico , Humanos , Masculino , Necrose/induzido quimicamente , Necrose/patologia , Deficiência de Proteína S/complicaçõesAssuntos
Animais , Masculino , Adulto , Pele/patologia , Varfarina/efeitos adversos , Deficiência de Proteína S/diagnóstico , Trombose Venosa/tratamento farmacológico , Anticoagulantes/efeitos adversos , Heparina de Baixo Peso Molecular/uso terapêutico , Deficiência de Proteína S/complicações , Necrose/induzido quimicamente , Necrose/patologiaRESUMO
Cutaneous metastasis is the main cause of morbidity and mortality of cancer patients, denoting a guarded prognosis. The clinical spectrum of the disease is broad and can mimic benign conditions. The diagnosis depends on thorough clinical examination and complementary exams, with emphasis on the histopathological study and immunohistochemistry. Because it indicates a systemic relapse, it is necessary to intervene with intravenous chemotherapy, to which local therapies can be associated. We report the case of a 65-year-old woman with cutaneous metastasis from breast cancer treated 14 years back, manifested by extensive firm and infiltrated red-purple plaques on the sides of the trunk, with a course of six months. After evaluation, she was referred to the regional cancer center. She passed away one month and a half later.
Assuntos
Neoplasias da Mama/patologia , Carcinoma/secundário , Neoplasias Cutâneas/secundário , Idoso , Carcinoma/diagnóstico , Evolução Fatal , Feminino , Humanos , Imuno-Histoquímica , Neoplasias Cutâneas/diagnósticoRESUMO
Abstract: Cutaneous metastasis is the main cause of morbidity and mortality of cancer patients, denoting a guarded prognosis. The clinical spectrum of the disease is broad and can mimic benign conditions. The diagnosis depends on thorough clinical examination and complementary exams, with emphasis on the histopathological study and immunohistochemistry. Because it indicates a systemic relapse, it is necessary to intervene with intravenous chemotherapy, to which local therapies can be associated. We report the case of a 65-year-old woman with cutaneous metastasis from breast cancer treated 14 years back, manifested by extensive firm and infiltrated red-purple plaques on the sides of the trunk, with a course of six months. After evaluation, she was referred to the regional cancer center. She passed away one month and a half later.
Assuntos
Humanos , Feminino , Idoso , Neoplasias Cutâneas/secundário , Neoplasias da Mama/patologia , Carcinoma/secundário , Neoplasias Cutâneas/diagnóstico , Imuno-Histoquímica , Carcinoma/diagnóstico , Evolução FatalRESUMO
Diffuse cutaneous melanosis is a rare complication of metastatic melanoma related to a worse prognosis. There are few cases reported in the literature. Its pathogenesis has not been completely elucidated, although studies have suggested certain mechanisms for its occurrence. It is clinically manifested as a blue-gray discoloration of the skin and mucous membranes in a cephalo caudal progression and usually associated with melanuria. Skin and mucosa histopathology reveals only the presence of melanophages in the dermis, mainly perivascular, and free interstitial melanin. We report the case of a 68-year-old male with metastatic melanoma, diffuse hyperpigmentation of the skin and melanuria.
Assuntos
Melanoma/complicações , Melanose/etiologia , Neoplasias Cutâneas/complicações , Biópsia , Evolução Fatal , Humanos , Neoplasias Hepáticas/patologia , Neoplasias Pulmonares/patologia , Masculino , Melaninas/urina , Melanoma/patologia , Melanoma/secundário , Melanose/patologia , Melanose/urina , Pessoa de Meia-Idade , Pele/patologia , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/secundárioRESUMO
Abstract Diffuse cutaneous melanosis is a rare complication of metastatic melanoma related to a worse prognosis. There are few cases reported in the literature. Its pathogenesis has not been completely elucidated, although studies have suggested certain mechanisms for its occurrence. It is clinically manifested as a blue-gray discoloration of the skin and mucous membranes in a cephalo caudal progression and usually associated with melanuria. Skin and mucosa histopathology reveals only the presence of melanophages in the dermis, mainly perivascular, and free interstitial melanin. We report the case of a 68-year-old male with metastatic melanoma, diffuse hyperpigmentation of the skin and melanuria.