RESUMO
The presence of specific IgE antibodies directed against common microorganisms was analyzed in a population of children. These antibodies included Escherichia coli, Proteus spp., Pseudomonas spp., Klebsiella spp., Streptococcus spp. and Staphylococcus spp. The determination of these antibodies was done by radioimmunoassay. Comparisons were made according to the parameters of age and total IgE levels. These antibodies were found in a high proportion of the cases. Statistical analysis demonstrated that the different specific IgE antibodies were present in all children, none showing special relevance. All of the antibodies studied were found to be present in a higher number of cases in the groups of older children, and in the group of children with increased total IgE levels, a significantly higher number of cases with antibacterial specific IgE antibodies was observed. The presence and the variety of the antibodies might be conditioned by individual as well as environmental factors. The role of antibodies is not well known. Although they are frequently found in allergic children, there have not been enough cases studied to establish their involvement in allergy. Understanding the role of antibodies might be of interest in the study of allergic processes exacerbated by bacterial infections.
Assuntos
Anticorpos Antibacterianos/sangue , Imunoglobulina E/sangue , Fatores Etários , Argentina , Criança , Pré-Escolar , Feminino , Humanos , Lactente , MasculinoRESUMO
At the Pediatric Intensive Care Unit of the Provincial Regional Hospital, in Río Cuarto, Argentina, nearly all hospitalized infants showed clinical symptoms of septicaemia and gastroenteritis. Neither Salmonella nor Shigella were found in the stool cultures, but Klebsiella pneumoniae was isolated as predominant flora. Three haemocultures displayed K. pneumoniae and Enterobacter cloacae; the other three developed only E. cloacae. Since the infants came from different places and it was possible to isolate members of the Klebsielleae tribe from all of them, a hospital infection was suspected. Searching for the infectious source, K. pneumoniae was detected in the water bath used to keep the feeding-bottles at 37 degrees C. To clarify the existence of any relationship between the strains isolated from patients and from the water bath, several characteristics were compared: biotypes, haemolityc activity, antibiotic sensibility patterns, and pathogenicity, assessed as lethal dose 50%. Identical results were found for the biochemical tests of all the strains belonging to the same species. The antibiotic sensibility patterns and LD 50% showed quite similar values. All bacteria displayed haemolityc activity for rabbit and lamb erythrocytes. It could be considered that the septicaemia had an intestinal origin, and that the infection spread was due to the contamination of the water bath where the feeding bottles were kept.
Assuntos
Infecção Hospitalar/epidemiologia , Surtos de Doenças/epidemiologia , Unidades de Terapia Intensiva , Infecções por Klebsiella/epidemiologia , Antibacterianos/farmacologia , Argentina , Resistência Microbiana a Medicamentos , Enterobacter/isolamento & purificação , Fezes/microbiologia , Humanos , Lactente , Infecções por Klebsiella/microbiologia , Klebsiella pneumoniae/efeitos dos fármacos , Klebsiella pneumoniae/isolamento & purificaçãoRESUMO
At the Pediatric Intensive Care Unit of the Provincial Regional Hospital, in Río Cuarto, Argentina, nearly all hospitalized infants showed clinical symptoms of septicaemia and gastroenteritis. Neither Salmonella nor Shigella were found in the stool cultures, but Klebsiella pneumoniae was isolated as predominant flora. Three haemocultures displayed K. pneumoniae and Enterobacter cloacae; the other three developed only E. cloacae. Since the infants came from different places and it was possible to isolate members of the Klebsielleae tribe from all of them, a hospital infection was suspected. Searching for the infectious source, K. pneumoniae was detected in the water bath used to keep the feeding-bottles at 37 degrees C. To clarify the existence of any relationship between the strains isolated from patients and from the water bath, several characteristics were compared: biotypes, haemolityc activity, antibiotic sensibility patterns, and pathogenicity, assessed as lethal dose 50
. Identical results were found for the biochemical tests of all the strains belonging to the same species. The antibiotic sensibility patterns and LD 50
showed quite similar values. All bacteria displayed haemolityc activity for rabbit and lamb erythrocytes. It could be considered that the septicaemia had an intestinal origin, and that the infection spread was due to the contamination of the water bath where the feeding bottles were kept.
RESUMO
At the Pediatric Intensive Care Unit of the Provincial Regional Hospital, in Río Cuarto, Argentina, nearly all hospitalized infants showed clinical symptoms of septicaemia and gastroenteritis. Neither Salmonella nor Shigella were found in the stool cultures, but Klebsiella pneumoniae was isolated as predominant flora. Three haemocultures displayed K. pneumoniae and Enterobacter cloacae; the other three developed only E. cloacae. Since the infants came from different places and it was possible to isolate members of the Klebsielleae tribe from all of them, a hospital infection was suspected. Searching for the infectious source, K. pneumoniae was detected in the water bath used to keep the feeding-bottles at 37 degrees C. To clarify the existence of any relationship between the strains isolated from patients and from the water bath, several characteristics were compared: biotypes, haemolityc activity, antibiotic sensibility patterns, and pathogenicity, assessed as lethal dose 50
. Identical results were found for the biochemical tests of all the strains belonging to the same species. The antibiotic sensibility patterns and LD 50
showed quite similar values. All bacteria displayed haemolityc activity for rabbit and lamb erythrocytes. It could be considered that the septicaemia had an intestinal origin, and that the infection spread was due to the contamination of the water bath where the feeding bottles were kept.
RESUMO
Levamisole, a widely used antihelminthic drug, possesses immunotropic properties. It has been proved that children with recurrent infections of the respiratory tract who were given the drug, were capable of preventing the repetition of the infections. Twenty-seven (27) children with recurrent urinary tract infections without structural malformations were studied and in all of them, a diminished cellular immunity was detected (blastic transformation of lymphocytes, rosettes of T lymphocytes and the skin tests). The drug was administered in doses of 2.5 mg/k/day, twice a week, for eight months. During the period of study, in 21 children repetition of the infections were not detected and in 13, a significant improvement of the cellular immunity was achieved. In some children it was possible to prove a rise of the IgA secretary in the urine.
Assuntos
Imunidade Celular/efeitos dos fármacos , Levamisol/uso terapêutico , Infecções Urinárias/tratamento farmacológico , Adolescente , Criança , Pré-Escolar , Ensaios Clínicos como Assunto , Avaliação de Medicamentos , Feminino , Humanos , Levamisol/farmacologia , Ativação Linfocitária/efeitos dos fármacos , Masculino , Recidiva , Formação de Roseta , Linfócitos T/efeitos dos fármacosAssuntos
Testes de Hemaglutinação , Infecções Urinárias/diagnóstico , Pré-Escolar , Feminino , Humanos , Lactente , MasculinoAssuntos
Distúrbios Nutricionais/complicações , Punções , Cateterismo Urinário , Infecções Urinárias/diagnóstico , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , MétodosAssuntos
Nefropatias/fisiopatologia , Biópsia , Criança , Humanos , Rim/patologia , Testes de Função RenalRESUMO
Si bien las pruebas funcionales globales en el niño con patología renal, permiten una orientación evolutiva y terapéutica, los autores presentan 48 casos para demostrar las ventajas de los procedimientos selectivos y cuantitativos que están basados en la autonomía de los proceos parciales que integran la función del riñón. Para FG, CCPR y TM utilizan Inulina y p-amino hipurato de sodio. Además del TM de excreción efectúan las pruebas de acidez provocada, de concentración y recuento de sedimento. El material para el estudio histopatológico se obtiene dentro de los 8 días de realizado el clearance mediante punción biopsia transcutánea. Se efectúa además evaluaciones periódicas en 6 niños con el fin de estudiar las modalidades evolutivas de diversas nefropatías. Se hace un ensayo de sistematización teniendo en cuenta la independencia de los diferentes procesos que integran la función renal evaluada mediante los clearances selectivos. Es propósito esencial de la comunicación sostener que el estudio integral del nefrópata es racional y científicamente el medio más adecuado para su cabal comprención.