RESUMO

The unique circumstances created by the COVID-19 pandemic pose serious challenges to mood stability and emotional regulation at all ages. Although many people tend to react resiliently to stress, others appear to display emotional anxiety and depression-related symptoms. In this study, we carried out a survey (N = 10,053) during the first week of the general lockdown (quarantine) in Argentina to measure early affective reactions in Argentine adults. Respondents showed substantial anxious and depressive symptoms, with 33% and 23% of participants reporting possible depressive and anxious syndromes, respectively, with the youngest group (18 to 25 y.o.) showing the highest prevalence of symptoms. Even if prior mental health problems predisposed or aggravated the reaction, participants without prior complaints showed signs of psychological impact. Using linear regression, the most important independent variables related to depressive symptoms were the feeling of loneliness followed by daily stress. In the case of anxious states, the strongest variables were negative repetitive thinking and feeling of loneliness. Other psychological, economic, and social factors are discussed. This study is in line with previous literature that highlight the importance of the psychological impact of pandemics, but additionally demonstrates that these reactions are present at a large scale immediately after the start of quarantine with very low infectious rates as an early anticipatory adaptive reaction leading to potential negative outcomes from adjustment disorders to major disorders. In addition, the present results provide potentially relevant information about sudden environmental impacts on affective states and specific pathways for anxiety and depression to be expressed. We end by discussing implications for public policy based on considering the most vulnerable groups.

Assuntos

COVID-19 , Pandemias , Adulto , Ansiedade/epidemiologia , Argentina/epidemiologia , Controle de Doenças Transmissíveis , Depressão , Humanos , Saúde Mental , Quarentena , SARS-CoV-2 , Estresse Psicológico/epidemiologia

RESUMO

PURPOSE: To report a single-institutional experience with the use of magnetic resonance imaging (MRI)-guided radiotherapy for cancers of the head and neck. MATERIALS AND METHODS: Between October 2014 and October 2016, 18 patients with newly diagnosed cancers of the head and neck were prospectively enrolled on an institutional registry trial investigating the feasibility and efficacy of external-beam radiotherapy delivered using on-board MRI. All patients had biopsy-proven evidence of malignancy, measurable disease, and the ability to provide consent. None had previously received any treatment. Median dose was 70 Gy (range 54-70 Gy). MRI scans were obtained as part of an image-guided registration protocol for alignment prior to and during each treatment. Concurrent chemotherapy was administered to 14 patients (78%). Patient-reported outcomes were assessed using the University of Washington quality of life instrument. RESULTS: Seventeen of 18 patients completed the planned intensity-modulated radiotherapy (IMRT) treatment of which 15 (83%) had a complete response and 2 (11%) had a partial response based on initial post-therapy positron emission tomography (PET) at 3 months. The 1-year estimates of progression-free survival, overall survival, and local-regional control were 95, 96, and 95%, respectively. There were no treatment-related fatalities. The incidence of grade 3+ acute toxicity was 44%. The proportion of patients rating their health-related quality of life as "very good" or "outstanding" at 6 months and 1 year after completion of radiation therapy was 60 and 70%, respectively. CONCLUSIONS: MRI-guided radiotherapy achieves clinical outcomes comparable to contemporary series reporting on IMRT for head and neck cancer.

Assuntos

Carcinoma de Células Escamosas/radioterapia , Neoplasias de Cabeça e Pescoço/radioterapia , Imageamento por Ressonância Magnética/métodos , Planejamento da Radioterapia Assistida por Computador/métodos , Radioterapia Guiada por Imagem/métodos , Adolescente , Adulto , Idoso , Carcinoma de Células Escamosas/patologia , Feminino , Seguimentos , Neoplasias de Cabeça e Pescoço/patologia , Humanos , Processamento de Imagem Assistida por Computador/métodos , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Prospectivos , Dosagem Radioterapêutica , Radioterapia de Intensidade Modulada/métodos , Taxa de Sobrevida , Adulto Jovem

RESUMO

Intensity modulated radiation therapy (IMRT) is a technology intensive treatment modality involving the delivery of highly conformal dose distributions to patients. IMRT is becoming a standard of care for many disease sites and approximately 30%-60% of cancer patients in the United States receive IMRT treatments. Given the complexity of the IMRT treatment planning and delivery processes, a number of AAPM reports and guidance documents addressed the technical aspects of IMRT, including the need for comprehensive acceptance testing, commissioning, and QA programs for IMRT planning and delivery equipment. The implementation of these verification programs is essential to ensure the accuracy of IMRT delivery. Despite the critical role of patient-specific IMRT verification QA to ensure the safe delivery of IMRT treatments to patients as planned, there is little systematic guidance on the type of methodologies, tools, and acceptable tolerance levels that are needed in clinical practice. Furthermore, there are limited discussion on the pros and cons of the different delivery methods for QA measurements, and no recommendations on how to assess the clinical relevance of failed IMRT plans. LEARNING OBJECTIVES: 1. To discuss commonly employed IMRT measurement methods and discuss the pros and cons of each method. 2. To review methodologies for absolute dose verification (single small-volume, 1D, 2D methods), and review dose-difference, DTA, and Gamma analysis techniques including the variability of vendors implementation 3. To review IMRT QA passing rates for given tolerances and action levels, and discuss the clinical relevance of failed IMRT QA.