RESUMO

We report a case of Felty's syndrome in which neutropenia was corrected by a short-term treatment with recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF, 5 micrograms/kg/day s.c. for 14 days). Absolute neutrophil counts rose from 0.1 to 2.2 x 10(9)/l and remained > 1.0 x 10(9)/l 8 weeks after discontinuation of the GM-CSF therapy. A flare-up of arthritis and a decrease in platelet counts were observed.

Assuntos

Síndrome de Felty/tratamento farmacológico , Fator Estimulador de Colônias de Granulócitos e Macrófagos/administração & dosagem , Neutropenia/tratamento farmacológico , Adulto , Eosinófilos/efeitos dos fármacos , Síndrome de Felty/sangue , Síndrome de Felty/complicações , Feminino , Humanos , Contagem de Leucócitos/efeitos dos fármacos , Neutropenia/sangue , Neutropenia/etiologia , Neutrófilos/efeitos dos fármacos , Proteínas Recombinantes/administração & dosagem , Indução de Remissão , Fatores de Tempo

RESUMO

Aplastic anemia is a condition characterized by bone marrow hipoplasia and pancytopenia. Various etiologic agents are related to the acquired form of this disease but in many cases the causative agents remain obscure. Severe aplastic anemia has been treated by immunosuppression and allogeneic marrow transplantation.

Assuntos

Anemia Aplástica/terapia , Transplante de Medula Óssea , Terapia de Imunossupressão , Anemia Aplástica/etiologia , Anemia Aplástica/imunologia , Anemia Aplástica/cirurgia , Humanos