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El artículo sistematiza una concepción teórica y metodológica que sustenta el lugar como categoria espacial, dimensión de la existencia, a partir de la cual se materializan los objetos, fenómenos y procesos que se relacionan con la forma en la que se vive, en identidad con el entramado social y territorial en el que se desarrolla. A partir de la crítica de las fuentes bibliográficas registradas, emerge la espacialidad, en la que se insertan e imbrican los objetos de diverso carácter, la sociedad y sus acciones en su disposición, articulación y localización. El presente artículo deriva de un grupo de resultados del proyecto de investigación Proyección pedagógica de la Tarea Vida en los diferentes niveles educativos que se ejecuta en la Universidad de Camagüey Ignacio Agramonte Loynaz en el período enero 2020 - diciembre 2025 y tiene como objetivo sistematizar una concepción teórica y metodológica que sustente el estudio del lugar como categoría espacial para los estudios sociales. Entre los resultados se destaca la caracterización de las funciones del lugar; así como su comprensión como sistema, en el que están presentes dos totalidades, las que, en calidad de dimensiones, definen los atributos y características propias que trascienden el sistema; como un conjunto complejo de relaciones de carácter biofísico y cultural, sostenidas teóricamente desde su evolución, vistas desde una concepción práctico-actitudinal-espacial.

The article systematizes a theoretical and methodological conception that sustains the place as a spatial category, dimension of existence, from which the objects, phenomena and processes that are related to the way we live are materialized, in identity with the framework, social and territorial in which we develop. From the critique of the registered bibliographical sources, spatiality emerges as a process in which objects, processes of diverse character, society and its actions are inserted and intertwined in their arrangement, articulation and location. This article derives from a group of results from the research project Pedagogical projection of the Life Task at the different educational levels that is carried out at the University of Camagüey Ignacio Agramonte Loynaz in the period January 2020-December 2025 and aims to systematize a conception theoretical and methodological that supports the study of place as a spatial category for social studies. . Among the results, the characterization of the functions of the place stands out; as well as its understanding as a dialectical totality, in which two totalities are present, which, as dimensions, define the attributes and characteristics that transcend the system; as a complex set of relationships of a biophysical and cultural nature, theoretically sustained since its evolution, seen from a practical-attitudinal-spatial conception.

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There is a knowledge gap in the epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) causing bloodstream infections (BSIs) in Peru. Through a surveillance study in 13 hospitals of 10 Peruvian regions (2017-2019), we assessed the proportion of MRSA among S. aureus BSIs as well as the molecular typing of the isolates. A total of 166 S. aureus isolates were collected, and 36.1% of them were MRSA. Of note, MRSA isolates with phenotypic and genetic characteristics of the hospital-associated Chilean-Cordobes clone (multidrug-resistant SCCmec I, non-Panton-Valentine leukocidin [PVL] producers) were most commonly found (70%), five isolates with genetic characteristics of community-associated MRSA (CA-MRSA)-SCCmec IV, PVL-producer-(8.3%) were seen in three separate regions. These results demonstrate that hospital-associated MRSA is the most frequent MRSA found in patients with BSIs in Peru. They also show the emergence of S. aureus with genetic characteristics of CA-MRSA. Further studies are needed to evaluate the extension of CA-MRSA dissemination in Peru.

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Surveillance of antimicrobial resistance among gram-negative bacteria (GNB) is of critical importance, but data for Peru are not available. To fill this gap, a non-interventional hospital-based surveillance study was conducted in 15 hospitals across Peru from July 2017 to October 2019. Consecutive unique blood culture isolates of key GNB (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter spp.) recovered from hospitalized patients were collected for centralized antimicrobial susceptibility testing, along with linked epidemiological and clinical data. A total of 449 isolates were included in the analysis. Resistance to third-generation cephalosporins (3GCs) was present in 266 (59.2%) GNB isolates. Among E. coli (n = 199), 68.3% showed 3GC resistance (i.e., above the median ratio for low- and middle-income countries in 2020 for this sustainable development goal indicator). Carbapenem resistance was present in 74 (16.5%) GNB isolates, with wide variation among species (0% in E. coli, 11.0% in K. pneumoniae, 37.0% in P. aeruginosa, and 60.8% in Acinetobacter spp. isolates). Co-resistance to carbapenems and colistin was found in seven (1.6%) GNB isolates. Empiric treatment covered the causative GNB in 63.3% of 215 cases. The in-hospital case fatality ratio was 33.3% (92/276). Pseudomonas aeruginosa species and carbapenem resistance were associated with higher risk of in-hospital death. In conclusion, an important proportion of bloodstream infections in Peru are caused by highly resistant GNB and are associated with high in-hospital mortality.

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The Starling principle is a model that explains the transvascular distribution of fluids essentially governed by hydrostatic and oncotic forces, which dynamically allow vascular refilling according to the characteristics of the blood vessel. However, careful analysis of fluid physiology has shown that the principle, while correct, is not complete. The revised Starling principle (Michel-Weinbaum model) provides relevant information on fluid kinetics. Special emphasis has been placed on the endothelial glycocalyx, whose subendothelial area allows a restricted oncotic pressure that limits the reabsorption of fluid from the interstitial space, so that transvascular refilling occurs mainly from the lymphatic vessels. The close correlation between pathological states of the endothelium (eg: sepsis, acute inflammation, or chronic kidney disease) and the prescription of fluids forces the physician to understand the dynamics of fluids in the organism; this will allow rational fluid prescriptions. A theory that integrates the physiology of exchange and transvascular refilling is the "microconstant model", whose variables include dynamic mechanisms that can explain edematous states, management of acute resuscitation, and type of fluids for common clinical conditions. The clinical-physiological integration of the concepts will be the hinges that allow a rational and dynamic prescription of fluids.

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Tarantula venoms may be a natural source of new vasodilator components useful in pharmacological research. Moreover, biological function data of the venoms are important to enhance the knowledge about the biodiversity and evolution of these species. The present study aims to describe the vasodilatory activity induced by the venom of Poecilotheria ornata on isolated rat aortic rings. This venom induced a vasodilator activity that was significantly reduced after incubation with L-NAME or ODQ. Measurements of nitrite concentrations on rat aorta homogenates showed that the venom significantly increased the basal levels. Moreover, the venom attenuates the contraction induced by calcium. These results suggest that P. ornata venom contains a mixture of vasodilator components that act through the activation of the nitric oxide/cGMP pathway, as well as, through an endothelium-independent mechanism that involves the calcium influx into vascular smooth muscle cells.

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El envejecimiento poblacional es uno de los problemas más latentes en la realidad actual cubana. Según cifras de la ONEI la población de más de 60 años asciende a más de dos millones de personas. Este es un fenómeno presente a lo largo del ciclo vital desde el mismo proceso de la concepción hasta la muerte; el que, a pesar de ser un fenómeno natural conocido por todos, ha resultado a muchos difícil aceptarlo como una realidad innata a todo ser. Dada la gran complejidad de los cambios que se producen durante el mismo, no ha de sorprender la existencia de más de 300 teorías a los fines de explicar el dónde, el cómo y el porqué de estos cambios. En el presente artículo se caracteriza doctrinalmente el fenómeno del envejecimiento poblacional en Cuba como proceso irreversible, único, individual, universal de cambio que involucra todas las dimensiones del ser humano y disminuye la velocidad de los procesos del cuerpo; sustentado su análisis en los fundamentos teóricos del mismo, así como en la visión totalizadora, que permite asumirlo como totalidad dialéctica, por ello se asume como objetivo Sistematizar una concepción teórica y metodológica que sustente el carácter polisémico del proceso de envejecimiento de la población. El estudio se desarrolla en el momento actual, como parte de un proceso de investigación que se acomete en el Tribunal Provincial de La Habana.

Population aging is one of the most latent problems in the current Cuban reality. According to ONEI figures, the population over 60 years of age amounts to more than two million people. This is a phenomenon present throughout the life cycle from the very process of conception until death; which, despite being a natural phenomenon known to all, has been difficult for many to accept as an innate reality to all beings. Given the great complexity of the changes that occur during it, it is not surprising that there are more than 300 theories in order to explain the where, how and why of these changes. In this article, the phenomenon of population aging in Cuba is doctrinally characterized as an irreversible, unique, individual, universal process of change that involves all dimensions of the human being, and slows down the processes of the body; Supporting its analysis on its theoretical foundations, as well as on the totalizing vision, which allows it to be assumed as a dialectical totality, for this reason it is assumed as an objective to Systematize a theoretical and methodological conception that supports the polysemic nature of the aging process of the population. The study is being carried out at the present time, as part of an investigation process that is being undertaken in the Provincial Court of Havana.

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BACKGROUND: The increased expression of B cell-activating factor (BAFF) has been linked to autoantibody production in autoimmune diseases (ADs). The aim of this study was to investigate the association among TNFSF13B gene (OMIM: 603969) single nucleotide polymorphisms (SNPs), TNFSF13B mRNA, and soluble BAFF (sBAFF) expression in patients with rheumatoid arthritis (RA) and primary Sjögren's syndrome (pSS). The diagnostic value of sBAFF also was evaluated by the area under the curve (AUC) of receiver operating characteristic or receptor (ROC) curves. METHODS: Genotypes of the TNFSF13B rs9514827 (-2841 T > C), rs1041569 (-2701 A > T) and rs9514828 (-871 C > T) SNPs were determined by PCR-RFLP assay. TNFSF13B mRNA and sBAFF expression were performed by RT-qPCR and ELISA, respectively. The study included 320 RA patients, 101 pSS patients, and 309 healthy subjects (HS). RESULTS: The rs9514828 T allele and the TAT haplotype were associated with an increased risk to develop RA. In both ADs, the TNFSF13B mRNA levels were increased in comparison with HS. The rs9514828 (-871 C > T) polymorphism was associated with increased gene expression in RA patients. Also, sBAFF levels were higher in both ADs, however pSS patients showed the highest sBAFF levels. sBAFF showed higher diagnostic performance for pSS with an AUC of 0.968, with a similar accuracy of anti-SSA/Ro antibody diagnosis (AUC = 0.974). CONCLUSIONS: Our findings demonstrate that the TNFSF13B rs9514828 (-871 C > T) polymorphism is a risk factor for RA in the western Mexican population. sBAFF levels may be a potential diagnosis biomarker in pSS.

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RESUMEN Introducción: El presente trabajo tiene como objetivo proponer el enfoque de seguridad alimentaria sostenible como respuesta a los desafíos emergentes. Método: Se emplea la estructura de identificación de enfoques, 1) fundamentos teóricos, de tipo científico - particulares, 2) la objetivación epistémica y 3) la evaluación funcional, soportada en el análisis documental de estudios teóricos, metodologías, documentos institucionales y proyectos. Resultados: Se propone el enfoque de seguridad alimentaria sostenible, su posible respuesta a los desafíos emergentes mediante el vínculo entre los indicadores seleccionados y estos desafíos, así como los principios bajo los que debe operar. Discusión: Como tendencia los enfoques de seguridad alimentaria se clasifican en tradicional y emergente, así como por su evolución temporal en etapas, en este estudio se clasifican en tradicional, de seguridad alimentaria y nutricional, emergente y se propone el enfoque de seguridad alimentaria sostenible.

ABSTRACT Introduction: The present work aims to propose the sustainable food security approach as a response to emerging challenges. Method: The structure of identification of approaches is used, 1) theoretical foundations, of a scientific - particular type, 2) epistemic objectification and 3) functional evaluation, supported by the documentary analysis of theoretical studies, methodologies, institutional documents and projects. Results: The sustainable food security approach is proposed, its possible response to emerging challenges through the link between the selected indicators and these challenges, as well as the principles under which it should operate. Discussion: As a trend, food security approaches are classified as traditional and emerging, as well as by their temporal evolution in stages, in this study they are classified as traditional, food and nutritional security, emergent and the sustainable food security approach is proposed.

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This study aimed to summarize the epidemiological and clinical characteristics of COVID-19 from Western Mexico people during 2020. A retrospective analysis from an electronic database of people visiting a sentinel center for molecular SARS-CoV-2 confirmatory diagnosis by RT-PCR from April to December 2020 was carried out for epidemiological and clinical description of COVID-19. Out of 23,211 patients evaluated, 6918 (29.8%) were confirmed for SARS-CoV-2 infection (mean age 38.5 ± 13.99), mostly females (53.8%). Comorbidities, such as diabetes (34.7%), obesity (31.15%), and hypertension (31.8%), presented an increased odds OR = 1.27, CI = 1.14-1.41; OR = 1.08, CI = 1.01-1.16; and OR = 1.09, CI = 0.99-1.19, respectively, for viral-infection. Moreover, fever, headache, and dry cough were the most frequent symptoms. No infection difference among sex was found. Those patients >60 years old were prone to COVID-19 severity (OR = 3.59, CI = 2.10-6.14), evaluated by the number of manifested symptoms, increasing with age. In conclusion, a high SARS-CoV-2 prevalence was found in Western Mexico. Comorbidities were frequent in infected people; nevertheless, no association with disease outcomes was observed, in contrast with the highest disease severity risk found in older patients; however, continuous monitoring should be carried since comorbidities have been reported as aggravating factors. This study can help the health officials for the elaboration of planning efforts of the disease management and others in the future.

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Abstract As a result of the COVID-19 pandemic, measures have been taken globally to shut down schools at all levels and move education to the online arena, which entails a strong dependence on access to the internet and electronic gadgets. Measures such as these are bound to deepen already existing inequality and bring about major disruptions in the students' learning process. In this context, the makeup of our diverse Mexican society and school communities calls for a political framework that promotes equal education and ensures a way of constructing knowledge that is accessible to all; a perspective in education that respects traditional groups and cultures, especially those who are usually financially disadvantaged, such as indigenous people. This article examines measures taken to support provision of online education, in general, and indigenous groups, in particular. The data collection approach to support the findings consisted of reviewing official websites from UNESCO, the Mexican Ministry of Education, and three states with the largest number of indigenous people (IP). The findings suggest that the production of TV programs and school booklets in indigenous languages show a considerable effort to reach out to indigenous communities throughout the country. Nevertheless, the measures taken by the national and state governments may still be deemed limited and somewhat biased in favor of monolingual students.

Resumo A pandemia da COVID-19 levou a medidas como o fechamento de todas as escolas em todos os níveis educacionais, e a transferência de suas atividades para a arena online, o que implica uma forte dependência do acesso à Internet e dispositivos eletrônicos. Medidas como essas tendem a aprofundar a desigualdade já existente e causar grandes interrupções no processo de aprendizagem dos alunos. Nesse contexto, a configuração da diversificada sociedade mexicana e das comunidades escolares exige uma estrutura política que promova a educação igualitária e garanta uma forma de construção do conhecimento acessível a todos; uma perspectiva de educação que respeite os grupos e culturas tradicionais, especialmente aqueles que geralmente são desfavorecidos financeiramente, como os indígenas. Este artigo examina as medidas tomadas para apoiar a oferta de educação online, em geral, e a oferta para grupos indígenas, em particular. A abordagem de coleta de dados para apoiar os resultados consistiu na revisão dos sites oficiais da UNESCO, do Ministério da Educação mexicano e de três estados com o maior número de povos indígenas . Os resultados sugerem que a produção de programas de TV e livretos escolares em línguas indígenas falam de um esforço considerável para alcançar as comunidades indígenas em todo o país. No entanto, as medidas tomadas pelos governos nacional e estaduais podem ser consideradas ainda limitadas e um tanto tendenciosas a favor dos alunos monolíngues.

Resumen Como resultado de la pandemia de COVID-19, se han tomado medidas a nivel mundial para cerrar las escuelas en todos los niveles y trasladar la educación al ámbito en línea, lo que implica una fuerte dependencia del acceso a internet y dispositivos electrónicos. Medidas como estas seguramente profundizarán la desigualdad ya existente y provocarán grandes interrupciones en el proceso de aprendizaje de los estudiantes. En este contexto, la conformación de nuestra diversificada sociedad y de las comunidades escolares mexicanas exige un marco político que promueva la educación equitativa y asegure una forma de construcción del conocimiento accesible a todos; una perspectiva educacional que respete los grupos y culturas tradicionales, especialmente aquellos que suelen estar en desventaja económica, como los pueblos indígenas. Este artículo examina las medidas adoptadas para apoyar la provisión de educación en línea, en general, y a los grupos indígenas, en particular. El enfoque de recopilación de datos para respaldar los hallazgos consistió en revisar los sitios web oficiales de la UNESCO, del Ministerio de Educación de México y de tres estados con mayor número de pueblos indígenas (PI). Los resultados sugieren que la producción de programas de televisión y folletos escolares en lenguas indígenas demuestra un esfuerzo considerable para llegar a las comunidades indígenas de todo el país. Sin embargo, las medidas tomadas por los gobiernos nacional y de los estados pueden considerarse aún limitadas y algo sesgadas a favor de los estudiantes monolingües.

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The epidemiological behavior of six Leptospira serovarieties was analyzed by spatial autocorrelation and co-occurrence of leptospirosis, diagnosed in goat herds located in the State of Guanajuato, Mexico. A total of 1650 goat serum samples were analyzed by microscopic agglutination (MAT). True prevalence (Pv) and 95% confidence interval (CI95) were determined. Spatial autocorrelation was calculated using the spdep package, applying the global Moran's I and local Moran's I of Leptospira in Guanajuato. The probabilistic model of co-occurrence was applied using the co-occur package. Seroprevalence in the State was found to be 45.5% (CI95 42.96; 48.06%). The highest registered frequency was for the Icterohemorrhagiae serovar (Pv 34.16%; CI95 31.74, 36.65%), followed by the serovar Hardjo-prajitno (Pv: 6.77%; CI95 5.33, 8.40%). Other serovarieties showed a Pv < 5%. Global spatial autocorrelation, only for the Icterohemorrhagiae serovar, was I > 1, while local Moran's I revealed that five of the six Leptospira serovarieties were spatially correlated. The probabilistic model of co-occurrence detected negative associations between Icterohemorrhagiae and the other serovarieties. The current study demonstrates the presence of Leptospira in goat herds of the State of Guanajuato. The diagnosed serovarieties show an aggregation pattern associated to risk zones and disease-transmitting vectors. Antibody co-occurrence analysis revealed dominance of the Icterohemorrhagiae serovar. A multidisciplinary approach including spatial epidemiology, ecological analyses, and serological vigilance will generate useful information for the prevention and control of leptospirosis in caprine production units.

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OBJECTIVES: To understand user preferences related to the characteristics of an application that promotes and provides education on healthy habits to correctly design multimedia elements. METHODS: We conducted a comprehensive qualitative study with a hermeneutical strategy, which gathered information using well-researched questions that were posed to focus groups consisting of 32 participants. These participants were asked for opinions related to multimedia elements to display educational messages about physical activity and healthy eating in a mobile application. There were three analysis categories of multimedia elements: text, visual elements, and audio elements. RESULTS: The majority of the participants, 93.75%, were in the low socioeconomic stratum; 68.75% are in a civil union with their partner; 53.12% completed or failed to complete secondary school, and 68.75% were housewives. Based on the qualitative results, we found that mobile applications become mediating tools that support the adoption of actions that tend to improve lifestyles and increase knowledge about proper nutrition and physical activity. Text messages used in mobile applications should promote healthy habits and remind users of their benefits. Images and videos should be accompanied by text and audio to provide greater clarity regarding recommendations of healthy habits. CONCLUSIONS: Technology must provide accessibility and coverage opportunities, while meeting the needs and expectations of users. It should facilitate primary health intervention through education to transform unhealthy behaviors and generate lifestyles that improve the health of the user and their family context.

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Resumen Objetivo: Identificar los cambios en la composición corporal posterior a un programa de rehabilitación cardíaca fase II. Materiales y métodos: Se siguió un grupo de 20 pacientes luego de al menos 36 sesiones de ejercicio supervisado dentro de un programa de rehabilitación cardiaca. Se midió la composición corporal (masa magra y grasa) antes y después por medio de Absorciometría de Energía Dual de Rayos X. Resultados: Se encontró que el cambio en la masa grasa total no fue significativo; sin embargo, la disminución en la masa grasa total en hombres tuvo una correlación positiva fuerte con la disminución del tejido adiposo visceral con r = 0,85 (p 0,0002). Hubo aumento significativo en masa magra total de 1,76% (p 0,053), destacado en la masa magra de piernas en 5,21% (p 0,001). El índice de masa muscular esquelética tuvo un aumento estadísticamente significativo 2,27% (p 0,016), más notable en hombres. Se encontró un aumento no significativo del peso de 0,38 kg en promedio. Hubo un aumento de cambio significativo en equivalentes metabólicos con aumento de 2,62 a 6,35 MET (p < 0,0001) y aumento de 1,22% (p 0,031) en la tasa metabólica basal. Conclusión: Un programa de rehabilitación cardíaca mejora significativamente la tolerancia al ejercicio y aumenta la masa magra total, de piernas y el índice de masa muscular esquelética; no modifica el índice de masa corporal, el perímetro de cintura, ni la masa grasa total en forma significativa.

Abstract Objective: To identify changes in body composition after a phase II cardiac rehabilitation programme. Materials and methods: A group of 20 patients was followed up after at least 36 supervised sessions of exercise within a cardiac rehabilitation programme. The body composition (lean mass and fat mass) was measured before and after the programme using Dual Energy X-ray Absorptiometry. Results: Although it was found that the change in total fat mass was not significant, there was a strong positive correlation between the decrease in total fat mass in males and the decrease in visceral adipose tissue, with an r=0.85 (P=.0002). There was a significant increase in total lean mass of 1.76% (P=.053), highlighted in the lean mass of the legs with 5.21% (P=.001). The skeletal muscle mass index showed a statistically significant increase of 2.27% (P=.016), more notable in males. There was a non-significant increase (0.38 kg) in the mean weight. There was a significant change in metabolic equivalents (METS), with an increase from 2.62 to 6.35 MET (P<.0001), and an increase of 1.22% (P=.031) in basal metabolic rate. Conclusion: Although there was no change in body mass index, waist circumference, or total body fat, a cardiac rehabilitation programme significantly improved the tolerance to exercise. It also produced an increase in the skeletal muscle mass index, as well as the total lean mass, mainly in the legs.

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Introducción: La pandemia a la que nos enfrentamos globalmente ha impactado de manera importante a la práctica odontológica, ya que, debido al uso de aerosoles, es una profesión de alto riesgo de transmisión de COVID-19. Objetivos: Describir los conocimientos generales sobre el SARS-CoV-2, recomendaciones y medidas de protección en una muestra de odontólogos mexicanos. Material y métodos: Se realizó un estudio descriptivo, transversal utilizando un instrumento de evaluación que se distribuyó en línea a instituciones públicas, privadas y asociaciones dentales mexicanas. Los resultados fueron analizados por medio de estadística descriptiva. Resultados: La encuesta fue respondida por 1,286 odontólogos, el 73.1% reportó haberse capacitado recientemente acerca del SARS-CoV-2. En su mayoría conocen sobre grupos de riesgo, transmisión, características clínicas, y recomendaciones generales. La mayoría se encuentran atendiendo exclusivamente urgencias y demuestran conocimiento acerca de los equipos de protección personal y del protocolo de atención durante la pandemia. Conclusiones: Los odontólogos mexicanos cuentan con los conocimientos sobre las generalidades del SARS-CoV-2, así como sobre los protocolos de atención y equipos de protección personal para la atención de pacientes durante la pandemia por COVID-19 (AU)

Introduction: The current pandemic that we are facing globally has had a significant impact on dental practice, due to the use of aerosols it is a profession with high risk of CoViD 19 transmission. Objective: To describe the general knowledge about SARS-CoV-2, as well as on the recommendations and personal protective equipment in a sample of Mexican dentists. Material and methods: A descriptive, transversal study was carried out through an evaluation instrument distributed on-line during 20 consecutive days to several dental professionals of private and public institutions and Mexican dental associations. Results were analyzed using descriptive statistics. Results: 1,286 Mexican dental professionals completed the survey, 73.1% indicated having received training about SARS-CoV-2 and they mostly know about the individuals at higher risk, transmission, clinical features and general recommendations. Most of the dentists are exclusively attending urgencies as pulpal pain, abscess and dental traumatisms. Knowledge regarding the use of personal protective equipment was demonstrated, as well as the protocol of care during the pandemic. Conclusions: Mexican dentists have the knowledge on the generalities of SARS-CoV-2, on care protocols and protective measures for patient care during the CoViD-19 pandemic (AU)

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Introducción: La vitamina D en la piel tras la exposición solar se constituye en precursor y agente anabólico óseo que esti- mula el transporte activo de calcio a través de la mucosa intestinal. La Sociedad Europea de Aspectos Clínicos y Económicos de la osteoporosis y osteoartritis, recomienda que pacientes postmenopáusicas con niveles de 25 (OH) D menores de 50 nmol/L reciban suplementación entre 800 y 1000 UI diarias de vitamina D. Objetivo: Determinar en mujeres con osteoporosis el cambio porcentual de 25 (OH) D en sangre, con la administración de 100.000 UI. de vitamina D cápsulas una vez al mes, así como seguridad y grado de satisfacción con el tratamiento. Sujetos y métodos: Estudio observacional, descriptivo, longitudinal, en el que se incluyeron 44 mujeres que recibieron 100.000 UI de vitamina D una vez al mes por tres meses. Se realizó control de laboratorio pre y post-tratamiento a una sub- muestra no probabilística de 10 pacientes. Resultados: El 70% de casos refirió no tener comorbilidades. El valor inicial de vitamina D en la sub-muestra fue 23,5±10,1nmol/l; al final el promedio fue 27,2±9,6 nmol/l. Post-tratamiento los niveles de vitamina D aumentaron un 20% en más del 50% de casos. El 93% de casos no refirieron eventos adversos. Los eventos adversos reportados fueron gastro-intestinales, eventos ósteo-articulares y cefalea. La mayoría de casos reportaron encontrarse satisfechos con el tratamiento. Conclusión: El tratamiento fue muy bien tolerado, la mayoría de casos refirieron estar satisfechos con el tratamiento. Se observaron incrementos porcentuales significativos de 25 (OH) D en sangre luego de 12 semanas de tratamiento. Palabras clave: Vitamina D, osteoporosis, caracterización.

"Introduction: Vitamin D in the skin after sun exposure constitutes precursor and bone anabolic agent that stimulates the active transport of calcium through the intestinal mucosa. The European Society for Clinical and Economic Aspects of Os- teoporosis and Osteoarthritis, recommends that postmenopausal patients with 25 (OH) D levels less than 50 nmol / L receive supplementation between 800 and 1000 IU daily of vitamin D. Objective: Determine in women with osteoporosis the percentage change of 25 (OH) vitamin D in blood, with the adminis-tration of 100,000 IU of vitamin D caps once a month, as well as safety and degree of satisfaction with the treatment. Subjects and methods: Observational, descriptive and longitudinal study, which included 44 women who received 100,000 IU of vitamin D once a month for three months. Pre and Post-treatment laboratory control was performed on a non-proba- bilistic subsample of 10 patients. Results: The 70% of cases reported not having comorbidities. The initial value of vitamin D was 23.5 ± 10.1 nmol/l at the end the average was 27.2 ± 9.6 nmol/l in the subsample. Post-treatment increased Vit D. levels 20.4% in more than 50% of cases, 93% of cases did not report adverse events. The adverse events reported were gastro-intestinal, osteo-articular events and headache. The majority of cases reported being satisfied with the treatment. Conclusion: Treatment was very well tolerated, the majority of cases reported being satisfied with the treatment. Significant percentage increases of 25 (OH) D were observed in blood after 12 weeks of treatment. Key words: Vitamin D, osteoporosis, characterization."

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Chapala, the largest lake in Mexico, has a great potential for aquaculture and a community of some 2500 fishermen who are interested in this activity. However, diverse reports over the past two decades suggest that the fish there are contaminated with heavy metals, raising concern among consumers. Although more recent scientific studies have clarified that the metal content in the edible parts of fish is below allowable limits, the negative perception persists. The present study, therefore, was designed to evaluate the bioaccumulation of the metals Cu, Zn, Pb, As, and Cd in organs such as the muscles, liver, and gills of carp (Cyprinus carpio) cultured in Lake Chapala, and compared the results to fish cultured in a pond. Results after 473 days of monitoring showed that metal bioaccumulation in the muscles of the carp increased by 1.71, 0.50, and 12.36 µg/kg for Cu, Cd, and Pb, respectively, but Zn and As levels decreased by 7.84 and 131.7 µg/kg, respectively. The livers showed concentrations one or two times higher than the muscles in the case of Pb, Cu, Zn, and Cd. According to these results, the metal concentrations in the edible parts of these fish were below international standards for human consumption, and no significant differences were found between the bioaccumulation patterns in the muscles and livers of the carp cultured in the lake and those raised in the pond, except for Cd and Pb in the liver. Finally, no correlations were found between metal concentrations in the fish and lake sediments.

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ABSTRACT The ethanolic extract of Melipona beecheii Bennett 1831, propolis from Yucatán Mexico was evaluated in vitro for the determination of its phenolic compound content, antioxidant capacity and antifungal activity. The results were compared against those of the ethanolic extract of Apis mellifera propolis. The total phenolic content, flavonoid content and flavanones-dihydroflavonols content were assessed by colorimetric methods. The antifungal activity was assessed in vitro against Candida albicans. For the ethanolic extract of M. beecheii propolis; total phenolic content, was 263.25 ± 8.78 µg/ml, total flavonoid content was 768 ± 204 µg/ml and flavanones-dihydroflavonols content was 335.42 ± 15.08 µg/ml. For antioxidant activity assessed as DPPH scavenging and iron reducing power ethanolic extract of M. beecheii propolis reported IC50 of 32.47 and 1.60 µg/ml of gallic acid equivalent respectively. Regarding antifungal activity against C. albicans, the minimal inhibitory concentration and minimal fungicidal concentration for ethanolic extract of M. beecheii propolis were 1.62 ± 0.33 and 2.50 ± 0.22 µg/ml of dry extract; For both minimal inhibitory concentration and minimal fungicidal concentration, ethanolic extract of M. beecheii propolis required 30% less concentration of dry extract than ethanol extract of A. mellifera propolis to exert the same antifungal actions against C. albicans. To the best of our knowledge, this is the first report about the flavonoid and flavanones-dihydroflavonols content of M. beecheii propolis. Due to the lack of information available about the stingless bee's honeycomb products, the study and conservation of endemic honeybees should remain as an active focus of research.

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Resumen Introducción Las enfermedades cardiovasculares y las complicaciones de la diabetes mellitus representan las principales causas de mortalidad en adultos en México. La obesidad abdominal (OA) y las alteraciones en la tensión arterial (TA) son dos de sus determinantes fundamentales. Las alteraciones ocasionadas por estas entidades se han demostrado en niños a partir de los 3 años. Objetivo Analizar la asociación entre el estatus socioeconómico, episodios de carestía alimentaria, sedentarismo y consumo de embotellados con el desarrollo de obesidad y alteraciones en la TA en niños en edad escolar. Material y métodos En 264 participantes en edad escolar (6-12 años) se determinaron peso, talla, perímetro abdominal y TA. Mediante entrevista semiestructurada se valoró estatus socioeconómico, episodios de carestía alimentaria, ingesta de embotellados y sedentarismo. Se aplicaron pruebas de Chi-cuadrada, T- de Student para búsqueda de asociación. Resultados Se encontró una prevalencia del 28.4% para sobrepeso-obesidad en términos del IMC, 28% para obesidad abdominal, 15.7% en alteraciones de la TA. La OA y alteraciones en TA se asociaron con consumo de refrescos embotellados (p<0.001). En caso de presentarse carestía alimentaria la estrategia de afrontamiento (préstamo vs reorganización) guardó asociación significativa con OA (p=0.019). El sexo del participante no se asoció con IMC, aunque si con OA (p<0.01). Conclusiones El estatus socioeconómico guarda asociación con las alteraciones en IMC en aquellos participantes con carestía alimentaria periódica. Las estrategias empleadas por la familia determinan en gran medida los desenlaces en términos de variables antropométricas.

Abstract Introduction Cardiovascular diseases and the complications of diabetes mellitus account for most of adult mortality in Mexico. Abdominal obesity (AO) and alterations in blood pressure (BP) are two of its fundamental determinants. The pathological changes caused by these entities have been demonstrated in children from 3 years of age. Objective To analyze the association between socioeconomic status, episodes of food shortages, sedentary lifestyle and soft drinks consumption with the development of obesity and alterations in BP in children of school age in an elementary school during 2015-2016 in Mérida Yucatán México. Materials and methods 264 participants, aged between 6 and 12 years were evaluated for weight, height, abdominal perimeter, BP. Semi-structured interviews were used to determine socioeconomic status, episodes of food shortages, soft drinks consumption, and sedentary lifestyle. Descriptive statistics were determined; Chi-square tests and Student's T-tests were used for association analysis. Results A prevalence for overweigh in terms of BMI of 28.4% was found, 28% for abdominal obesity, and 15.7% for alterations of BP. Abdominal obesity and BP alterations were associated with consumption of bottled soft drinks (p <0.001). In case of food shortages, the coping strategy (loan vs reorganization was asociated with AO (p = 0.019). The sex of the participant was not associated with BMI, although it was with AO (p <0.01). Conclusions Socioeconomic status is associated with alterations in BMI. in those participants who had periodic shortages of food ,the strategy employed for dealing with the issue determines the outcomes in terms of anthropometric variables.

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A biosensor is a device composed by a biological recognition element and a transducer that delivers selective information about a specific analyte. Technological and scientific advances in the area of biology, bioengineering, catalysts, electrochemistry, nanomaterials, microelectronics, and microfluidics have improved the design and performance of better biosensors. Enzymatic biosensors based on lipases, esterases, and phospholipases are valuable analytical apparatus which have been applied in food industry, oleochemical industry, biodegradable polymers, environmental science, and overall the medical area as diagnostic tools to detect cholesterol and triglyceride levels in blood samples. This chapter reviews recent developments and applications of lipase-, esterase-, and phospholipase-based biosensors.

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RESUMEN Introducción: La dimensión ambiental constituye un proceso esencial en la formación de profesionales, de modo que en el desempeño de su profesión puedan educar hacia el desarrollo sostenible a las futuras generaciones. Objetivo: Representar en un modelo pedagógico la lógica de la dimensión ambiental en la formación laboral investigativa de los profesionales en la universidad. Materiales y métodos: Se utilizaron métodos teóricos, empíricos y matemáticos-estadísticos. Resultados: Elaboración del modelo pedagógico de dimensión ambiental en la formación laboral investigativa de los profesionales en formación. El modelo está estructurado en tres subsistemas: uno teórico, se centra en la integración de saberes pedagógico ambientales a partir de las relaciones que se establecen entre sus componentes, otro metodológico, el cual resume la proyección ambiental de la formación laboral investigativa y un subsistema procedimental, que manifiesta la instrumentación transformadora ambiental que debe ocurrir en los estudiantes. El modelo aporta una cualidad sinérgica que le imprime identidad, totalidad y contribuye a su autodesarrollo. Conclusiones: Con la elaboración del modelo se revelan nuevas interpretaciones que se manifiestan como relaciones teóricas funcionales surgidas entre los componentes de los subsistemas que lo integran y a la vez, entre los subsistemas como macro componentes. La validación del modelo resultó estadísticamente significativa, mediante la instrumentación de una estrategia pedagógica para la dimensión ambiental en la formación laboral investigativa.

ABSTRACT Introduction: The environmental component is an essential process in the training of professionals, that enables them to educate future generations towards sustainable development. Objective: To represent in a pedagogical model the logic of the environmental dimension in the research training of professionals. Materials and methods: Theoretical, empirical and mathematical-statistical methods were used. Findings: The development of the pedagogical model of environmental dimension in research and labor training of professionals. The model is structured in three subsystems: the first focuses on the integration of environmental pedagogical knowledge from the relationships established between its components; the second is of a methodological character and summarizes the environmental projection of research training; whereas the third one is procedural, expressing the environmental transformative instrumentation that must occur in students. The model provides a synergistic quality that consolidates identity, totality and contributes to its self-development. Conclusions: With the elaboration of the model new interpretations are revealed that are manifested as functional theoretical relations arising between the components of the subsystems that integrate it and at the same time, between the subsystems as macro components. The evaluation of the model was statistically significant, through the instrumentation of a pedagogical strategy for the environmental dimension in the research and labor training.