RESUMO
Se presenta un enfoque técnico de mercadeo social, que convierte al consumidor en el centro de la estrategia de planificación y de los estudios de mercado, para identificar los segmentos de la población que probablemente consumiran los “productos” de salud. Como se puede utilizar el mercadeo social para lograr cambios de comportamiento, sirviéndose de los conocimientos pertinentes en las disciplinas de mercadotecnia, comunicaciones, análisis de comportamientos, educación informal y antropología médica.
Assuntos
Comunicação , Saúde Pública Veterinária , Medicina VeterináriaRESUMO
Melatonin, the chief hormone of the pineal gland, has been reported to interact with a variety of different cells. This ubiquitously acting hormone has been found to interact with protein receptors both at the cell membrane and in the nucleus. Moreover, melatonin was recently shown to be a very potent hydroxyl radical scavenger. The present work focuses on the interaction of melatonin with pure lipid bilayers. It is shown that melatonin can cross multilamellar lipid vesicles, which are used here as model systems for the lipid phase of biological membranes. Thus, the data prove that melatonin can easily pass through the cell membrane and bath every part of the cell, as previously suggested in the literature. Melatonin lipid association constant was calculated based on the change of the hormone fluorescence intensity due to its penetration into the hydrophobic lipid phase. Though melatonin was recently shown to be highly soluble in aqueous media, its lipid association constant is rather high, indicating that the biological action of the hormone is likely to be at the membrane level, either via its interaction with membrane receptors, and/or as a lipoperoxidation radical scavenger.