RESUMO
Objective: To assess the efficacy of a single dose of oral meloxicam as an ancillary therapy to an antibiotic given at the time of respiratory disease identification on average daily gain (ADG), behavioral attitude, clinical respiratory, and lung ultrasound scores in preweaned dairy calves. Animals: 215 male and female Holstein, Jersey, and crossbred preweaned calves enrolled between 1 and 14 days of age at study enrollment on a single commercial dairy in the western US. Methods: The study took place from March 4, 2021, to November 21, 2021. In this double-blind placebo-controlled study, calves were given an antibiotic (1.1 mL of tulathromycin/kg, SC, once) and either a placebo (1 mg of lactose monohydrate/kg, in a gelatin capsule) or oral meloxicam (1 mg/kg) at the time of respiratory disease identification. Behavioral attitude, clinical respiratory, and lung ultrasound scores and ADG were assessed in preweaned dairy calves at different time points including the next health examination, 1 week later, or at weaning. Results: There was no association between treatment (placebo vs meloxicam) on ADG or respiratory disease status at weaning (P > .05). There was no effect of treatment on behavioral attitude, clinical respiratory, or lung ultrasound scores at the next health examination or 1 week later (P > .05). Clinical Relevance: The present study did not provide evidence that oral meloxicam given once is beneficial for growth, behavioral attitude, or clinical or lung ultrasound scores.
Assuntos
Doenças Respiratórias , Animais , Bovinos , Feminino , Masculino , Meloxicam/uso terapêutico , Doenças Respiratórias/diagnóstico , Doenças Respiratórias/tratamento farmacológico , Doenças Respiratórias/veterinária , Desmame , Antibacterianos/uso terapêutico , PulmãoRESUMO
Isokinetic strength testing has been widely used to assess athletic populations. The purpose of this study was to measure isokinetic strength in nonathletic able-bodied subjects to provide a subsequent comparison with nonathletic injured patients. Using a standard isokinetic protocol, with continuous verbal encouragement, a single investigator tested 16 women and nine men aged 20 to 30 years on an isokinetic dynamometer. Subjects had minimal athletic experience, and none were varsity performers. Peak torque as a percentage of body weight was statistically greater for men than for women in most joints tested both at 60 degrees and 180 degrees per second. The ratio of the last five to the first five of 25 repetitions at 180 degrees/second (Endurance Ratio = ER) rarely (ie, 5/154 tests) fell below the commonly accepted value of 50%. Many subjects had an endurance ratio of 100% or greater (range 4% to 171%). Peak torques were well below and endurance ratios well above those published for similarly aged athletes. The results suggest that before isokinetic testing is considered as a possible way to distinguish malingerers among injured patients, normal values in an age-matched, nonathletic, working population should be clearly defined. The endurance ratio may reflect the level of athletic training or the level of vigorous participation in an exercise program.