Assuntos
Neoplasias das Glândulas Suprarrenais/cirurgia , Feocromocitoma/cirurgia , Adolescente , Neoplasias das Glândulas Suprarrenais/complicações , Neoplasias das Glândulas Suprarrenais/diagnóstico , Anti-Hipertensivos/uso terapêutico , Arritmias Cardíacas/diagnóstico , Arritmias Cardíacas/tratamento farmacológico , Arritmias Cardíacas/etiologia , Eletrocardiografia/métodos , Humanos , Imageamento por Ressonância Magnética , Masculino , Feocromocitoma/complicações , Feocromocitoma/diagnósticoAssuntos
Acidose Tubular Renal/diagnóstico , Furosemida , Acidose Tubular Renal/classificação , Acidose Tubular Renal/complicações , Aldosterona/sangue , Bicarbonatos/sangue , Dióxido de Carbono/sangue , Cloretos/sangue , Furosemida/administração & dosagem , Humanos , Hidrocortisona/sangue , Lactente , Masculino , Potássio/sangue , Sódio/sangueRESUMO
Thirteen infants, 2 to 10 months of age, developed hypochloremic alkalosis (serum chloride 59 to 92 mEq/l) while taking Neo-Mull-Soy (Syntex), a soy-based formula low in chloride (measured to be 0 to 2 mEq/l) but with considerable potassium citrate. Range of symptoms included lethargy, anorexia, mild spitting up, diarrhea, hematuria, and growth failure. Urine chloride excretion was less than 3 mEq/l. Plasma renin activity or aldosterone, measured in six infants, was elevated. All responded promptly to supplemental salt. One infant receiving Neo-Mull-Soy redeveloped alkalosis when supplemental salt was discontinued. Two of nine apparently normal infants receiving Neo-Mull-Soy also had hypochloremia (85, 86 mEq/l). Three of four receiving Prosobee (Mead Johnson; Cl content 7 mEq/l) had urine chloride concentration less than 20 mEq/l. The chloride content of some infant formulas is insufficient to offset salt losses following mild stress.
Assuntos
Alcalose/etiologia , Cloretos/sangue , Alimentos Infantis/efeitos adversos , Humanos , Lactente , Alimentos Infantis/análise , Masculino , Glycine max/efeitos adversosAssuntos
Acidose/etiologia , Doenças do Recém-Nascido/etiologia , Leite/efeitos adversos , Animais , Cabras , Humanos , Recém-Nascido , MasculinoRESUMO
Standard values were established for urinary excretion and clearance of uric acid in 95 normal, nonhospitalized children. We found that urinary uric acid excretion and serum uric values increase throughout childhood; that in early childhood, fractional excretion and clearance of uric acid are higher than adult norms; and that despite an increasing filtered load of uric acid, there is a progressive decrease in fractional excretion and clearance of uric acid with advancing age. Some tubular maturational change, either decreasing secretion or increasing reabsorption, must account for the progressive decline in fractional excretion and clearance of uric acid.
Assuntos
Ácido Úrico/urina , Adolescente , Criança , Pré-Escolar , Humanos , Túbulos Renais/metabolismo , Taxa de Depuração Metabólica , Valores de Referência , Sódio/urina , Ácido Úrico/sangue , Ácido Úrico/metabolismoRESUMO
The relationship between the dosage of pancreatic extract and the excretion of uric acid was investigated in 29 patients with cystic fibrosis and exocrine pancreatic insufficiency. Urinary excretion of uric acid was normal in patients receiving small doses of pancreatic extracts and abnormally high in those receiving large amounts. In the latter group, normouricosuria was achieved by reducing the dose of pancreatic extract. Normal stool patterns and adequate weight gains were preserved by a diet modification that was well accepted by the patients. To eliminate the potential renal consequences of hyperuricosuria, it seems appropriate to control the need for increasing amounts of pancreatic enzymes by limiting the dietary intake of fat and maintaining a positive caloric and nitrogen balance with high intake of protein and carbohydrates and supplementation with medium-chain triglycerides.