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1.
Mol Ecol Resour ; 23(3): 712-724, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-36377253

RESUMO

Whole-genome alignment allows researchers to understand the genomic structure and variation among genomes. Approaches based on direct pairwise comparisons of DNA sequences require large computational capacities. As a consequence, pipelines combining tools for orthologous gene identification and synteny have been developed. In this manuscript, we present the latest functionalities implemented in NGSEP 4, to identify orthogroups and perform whole genome alignments. NGSEP implements functionalities for identification of clusters of homologus genes, synteny analysis and whole genome alignment. Our results showed that the NGSEP algorithm for orthogroups identification has competitive accuracy and efficiency in comparison to commonly used tools. The implementation also includes a visualization of the whole genome alignment based on synteny of the orthogroups that were identified, and a reconstruction of the pangenome based on frequencies of the orthogroups among the genomes. NGSEP 4 also includes a new graphical user interface based on the JavaFX technology. We expect that these new developments will be very useful for several studies in evolutionary biology and population genomics.


Assuntos
Genoma , Software , Genômica/métodos , Algoritmos , Metagenômica
2.
Rev. enferm. Inst. Mex. Seguro Soc ; 10(2): 89-91, Mayo-Ago. 2002. tab
Artigo em Espanhol | LILACS, BDENF - Enfermagem | ID: biblio-981814

RESUMO

El presente trabajo surge como una inquietud por conocer el riesgo que tienen los pacientes hospitalizados de presentar úlceras por decúbito e identificar si las acciones de enfermería son suficientes. Para obtener esta información se utilizó la escala de Norton, instrumento que permite valorar el riesgo de presentar úlceras por decúbito en el paciente y un cuestionario para identificar la valoración, cuidados a la piel, y cambios posturales que realiza la enfermera en los servicios seleccionados. Para el análisis estadístico se utilizaron las pruebas Anova y chi-cuadrada, en donde el puntaje global de riesgo no tuvo diferencia significativa, sólo en la categoría de edad se encontró que los pacientes en el servicio de medicina interna tienen una edad significativamente mayor a los de los servicios de neurología y neurocirugía. Al comparar las intervenciones que realiza la enfermera para prevenir úlceras de decúbito, en cada uno de los servicios, se encontró que son suficientes, con un porcentaje significativamente mayor en el servicio de medicina interna. Se concluyó que la escala de Norton permite valorar el riesgo que tienen los pacientes de presentar úlceras por decúbito, la enfermera debe aplicarla y con base en ésta realizar las intervenciones preventivas que le permitan brindar una atención de calidad.


The Present work arises like a restlessness to know the risk that the hospitalized patients have to present decubitus ulcers and to identify if the infirmary actions are enough. To obtain this information you uses the scale of Norton, instrument that allows to value the risk of presenting decubitus ulcers in the patient and a questionnaire to identify the valuation, cares to the skin, and changes posturales that the nurse carries out in the selected services. For the statistical analysis the tests Anova and chi were used-square where the global puntaje of risk didn't have significant difference, alone in the age category it was found that the patients in the service of Internal Medicine have a significantly bigger age to those of the services of Neurology and Neurosurgery. When comparing the interventions that the nurse carries out to prevent decubitus ulcers, in each one of the services, you/he/ she was found that they are enough, with a significantly bigger percentage in the service of Internal Medicine. Concluding that the scale of Norton allows to value the risk that you/they have the patients of presenting decubitus ulcers, the nurse should apply it and based on this to carry out the preventive interventions that allow him to offer an attention of quality.


Assuntos
Humanos , Pesos e Medidas , Epidemiologia Descritiva , Estudos Transversais , Inquéritos e Questionários , Interpretação Estatística de Dados , Enfermagem , Úlcera por Pressão , Hospitalização , Recursos Humanos de Enfermagem , México
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