RESUMO
O objetivo da presente pesquisa foi avaliar se a administraçäo prévia de vacina oral antipoliomielite, tipo Sabin (VOP-Sabin), interfere na eficácia sorológica da vacina do sarampo. Com essa finalidade estudaram-se 117 crianças, de nove meses de idade, que receberam vacina de vírus vivo atenuado do sarampo (cep BIKEN CAM 70) no período de quatro semanas, ou menos, após terem recebido vacina oral antipoliomielite (VOP-Sabin), e 88 crianças, da mesma faixa etária mas sem vacinaçäo recente com a VOP-Sabin, como controle. Os anticorpos IgG para o sarampo foram pesquisados mediante a reaçäo de imunofluorescência indireta. A proporçäo de soroconversäo para a vacina do sarampo foi de 19/23 (82,6%) nas crianças que tinham recebido a VOP-Sabin 2 a 6 dias antes; 29/37 (78,4%), nas que receberam VOP-Sabin 9 a 13 dias antes; 32/42 (76,2%), nas vacinadas com a VOP-Sabin 16 a 20 dias antes; e 12/15 (80,0%), nas vacinadas com intervalos de 23 a 26 dias. A proporçäo de soroconversäo no grupo controle (vacinadas quatro semanas ou mais após a VOP-Sabin) foi de 68/88 (77,8%) e a comparaçäo destas proporçöes näo mostrou diferenças estatisticamente significativas. Os resultados obtidos näo demonstraram, portanto, uma menor eficácia sorológica para a vacina do sarampo em crianças previamente vacinadas contra a pólio que recebram a vacina Sabin durante as quatro semanas anteriores
Assuntos
Lactente , Humanos , Vacina contra Sarampo/farmacologia , Vacina Antipólio Oral/farmacologia , Interferência Viral , BrasilRESUMO
The purpose of this study was to determine whether Sabin oral polio vaccine (OPV-Sabin) interferes with the serologic efficacy of measles vaccine administered subsequently. To this end, a study was made of 117 infants nine months old to whom attenuated live measles virus vaccine (BIKEN CAM 70 strain) was administered within a period of four weeks or less after receiving oral polio vaccine (OPV-Sabin), and of a control group of 88 infants of the same age to whom OPV-Sabin had not been recently administered.IgC antibodies to measles were studied by indirect inmunofluorescence. The proportion of seroconversion for measles vaccine was 19/23 (82.6 per cent) in the infants who had received OPV-Sabin two to six days before, 29/37(78.4 per cent) in those who had received OPV-Sabin nine to thirteen days before, 32/42 (76.2 per cent) in those in which OPV-sabin had been given 16 to 20 days before, and 12/15 (80.0 per cent) in the infants who had received the two vaccinations 23 to 26 days apart. The proportion of seroconversion in the control group (the infants vaccinated for weeks or longer after having received OPV-Sabin) was 68/88 (77.8 per cent). A comparison of these ratios brought out no statistically significant differences. Hence, the results obtained do no show reduced serologic efficacy of measles vaccine in infants