RESUMO
We are currently facing a worldwide epidemic of syphilis. Clinical manifestations that are rarely seen have been encountered, leading the dermatologist to confront unusual clinical conditions in daily practice. Erythema multiforme triggered by syphilis is very rare and is also seldom reported in the literature. We report a case of secondary syphilis in an HIV-positive patient, whose clinical, pathologic and serologic features were consistent with the diagnosis of erythema multiforme triggered by syphilis
Assuntos
Humanos , Masculino , Adulto , Infecções por Treponema , Sorodiagnóstico da Sífilis , Infecções por HIV , Eritema Multiforme/diagnósticoRESUMO
We are currently facing a worldwide epidemic of syphilis. Clinical manifestations that are rarely seen have been encountered, leading the dermatologist to confront unusual clinical conditions in daily practice. Erythema multiforme triggered by syphilis is very rare and is also seldom reported in the literature. We report a case of secondary syphilis in an HIV-positive patient, whose clinical, pathologic and serologic features were consistent with the diagnosis of erythema multiforme triggered by syphilis.
Assuntos
Eritema Multiforme/etiologia , Infecções por HIV/complicações , Sífilis/diagnóstico , Treponema pallidum/isolamento & purificação , Adulto , Antibacterianos/uso terapêutico , Biópsia , Eritema Multiforme/complicações , Eritema Multiforme/diagnóstico , Eritema Multiforme/tratamento farmacológico , Humanos , Penicilina G/uso terapêuticoRESUMO
Anetoderma is a rare benign condition of diverse etiology whose characteristic is the diminution or absence of the dermal elastic fibers. Classified as primary and secondary, the latter associated with tumors, inflammatory, and infectious diseases. Although the etiology of the lesions is well described in literature, the pathogenesis is still poorly determined. Anetoderma in syphilis is rare, and occurs even in the most uncommon cutaneous manifestations of the disease, such as the nodular form. In order to better understand the changes that lead to elastolysis, we propose a better correlation with the histopathological findings of the lesions that precede it. We present two cases of anetoderma secondary to syphilis, whose clinical aspects resembled the pattern of their initial secondary syphilis rash.
Assuntos
Anetodermia/tratamento farmacológico , Anetodermia/etiologia , Tecido Elástico/patologia , Penicilina G Benzatina/uso terapêutico , Sífilis/complicações , Adulto , Anetodermia/diagnóstico , Anetodermia/patologia , Biópsia , Feminino , Humanos , Penicilina G Benzatina/efeitos adversos , Pele/patologia , Dermatopatias , Sífilis/patologia , TerapêuticaRESUMO
Epidermal melasma is a common hyperpigmentation disorder that can be challenging to treat. Although current treatment options for melasma are limited, topical skin-lightening preparations have widely been used as alternatives to hydroquinone. In this prospective, single-arm, open-label study, treatment of epidermal melasma with a novel cream formulation containing nicotinamide 4%, arbutin 3%, bisabolol 1%, and retinaldehyde 0.05% was associated with reductions in Melasma Area and Severity Index (MASI) scores as well as total melasma surface area as measured by medical imaging software. Treatment outcomes including tolerance and safety profiles as well as patient satisfaction and product appreciation showed this novel cosmetic compound may be valuable in the treatment of epidermal melasma.
Assuntos
Fármacos Dermatológicos/administração & dosagem , Melanose/tratamento farmacológico , Satisfação do Paciente , Administração Cutânea , Adolescente , Adulto , Arbutina/administração & dosagem , Fármacos Dermatológicos/efeitos adversos , Feminino , Humanos , Processamento de Imagem Assistida por Computador , Melanose/patologia , Pessoa de Meia-Idade , Sesquiterpenos Monocíclicos , Niacinamida/administração & dosagem , Estudos Prospectivos , Retinaldeído/administração & dosagem , Sesquiterpenos/administração & dosagem , Índice de Gravidade de Doença , Creme para a Pele , Software , Resultado do Tratamento , Adulto JovemRESUMO
Pachyonychia congenita is a rare genetic disorder characterized mainly by hypertrophy of the nails and hyperkeratosis of the skin and mucosae. Fifty percent of all patients have oral leukokeratosis, which is often painful. The case reported here is of a 41-year-old patient who had white lesions in the form of irregular plaques; these affected multiple regions of the oral mucosa and were sensitive to touch. Histological examination revealed acanthosis, parakeratosis and ballooning of the epithelial cells, consistent with oral leukokeratosis. After therapy including topical steroids and prosthetic rehabilitation, the symptoms resolved.