1.
J Pediatr
; 149(6): 871-3, 2006 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17137910
RESUMO
Six of 22 mothers with gestational diabetes mellitus had infants with macrosomia, cord blood hyperinsulinemia, and increased amounts of a key mitogenic intermediate, farnesylated p21-Ras. The ability of fetal hyperinsulinemia to increase the availability of farnesylated p21-Ras may represent one mechanism of the growth-promoting action of insulin during fetal development.