RESUMO
PURPOSE: Optical coherence tomography (OCT) captures retinal damage in neuromyelitis optica spectrum disorders (NMOSD). Previous studies investigating OCT in NMOSD have been limited by the rareness and heterogeneity of the disease. The goal of this study was to establish an image repository platform, which will facilitate neuroimaging studies in NMOSD. Here we summarise the profile of the Collaborative OCT in NMOSD repository as the initial effort in establishing this platform. This repository should prove invaluable for studies using OCT to investigate NMOSD. PARTICIPANTS: The current cohort includes data from 539 patients with NMOSD and 114 healthy controls. These were collected at 22 participating centres from North and South America, Asia and Europe. The dataset consists of demographic details, diagnosis, antibody status, clinical disability, visual function, history of optic neuritis and other NMOSD defining attacks, and OCT source data from three different OCT devices. FINDINGS TO DATE: The cohort informs similar demographic and clinical characteristics as those of previously published NMOSD cohorts. The image repository platform and centre network continue to be available for future prospective neuroimaging studies in NMOSD. For the conduct of the study, we have refined OCT image quality criteria and developed a cross-device intraretinal segmentation pipeline. FUTURE PLANS: We are pursuing several scientific projects based on the repository, such as analysing retinal layer thickness measurements, in this cohort in an attempt to identify differences between distinct disease phenotypes, demographics and ethnicities. The dataset will be available for further projects to interested, qualified parties, such as those using specialised image analysis or artificial intelligence applications.
Assuntos
Neuromielite Óptica , Inteligência Artificial , Ásia , Europa (Continente) , Humanos , Neuromielite Óptica/diagnóstico por imagem , América do Sul , Tomografia de Coerência Óptica , Acuidade VisualRESUMO
Este texto versa sobre a relação que as crianças têm/podem ter num museu, em particular nos museus de arte, compreendendo-os como espaços de troca, descoberta, produção de sentido, criação, mas, sobretudo, espaços de memória, de história, de vida. Sublinha-se aqui a importância, para seu processo de formação como sujeito social, histórico e cultural, dos elos e associações que a criança faz/pode fazer a partir de suas experiências estéticas com representações culturais de outros tempos-espaços e com pessoas de outras gerações.