RESUMO

OBJECTIVE: The purpose of this study was to determine whether maternal/fetal single nucleotide polymorphisms (SNPs) in candidate genes are associated with spontaneous preterm labor/delivery. STUDY DESIGN: A genetic association study was conducted in 223 mothers and 179 fetuses (preterm labor with intact membranes who delivered <37 weeks of gestation [preterm birth (PTB)]), and 599 mothers and 628 fetuses (normal pregnancy); 190 candidate genes and 775 SNPs were studied. Single locus/haplotype association analyses were performed; the false discovery rate was used to correct for multiple testing. RESULTS: The strongest single locus associations with PTB were interleukin-6 receptor 1 (fetus; P=.000148) and tissue inhibitor of metalloproteinase 2 (mother; P=.000197), which remained significant after correction for multiple comparisons. Global haplotype analysis indicated an association between a fetal DNA variant in insulin-like growth factor F2 and maternal alpha 3 type IV collagen isoform 1 (global, P=.004 and .007, respectively). CONCLUSION: An SNP involved in controlling fetal inflammation (interleukin-6 receptor 1) and DNA variants in maternal genes encoding for proteins involved in extracellular matrix metabolism approximately doubled the risk of PTB.

Assuntos

Estudos de Associação Genética , Trabalho de Parto Prematuro/genética , Polimorfismo de Nucleotídeo Único , Receptores de Interleucina-6/genética , Adulto , Estudos de Casos e Controles , Chile , Corioamnionite/genética , Matriz Extracelular/genética , Matriz Extracelular/metabolismo , Feminino , Ruptura Prematura de Membranas Fetais/genética , Predisposição Genética para Doença , Variação Genética , Haplótipos , Humanos , Recém-Nascido , Recém-Nascido Pequeno para a Idade Gestacional/fisiologia , Pré-Eclâmpsia/genética , Gravidez , Nascimento Prematuro/genética , Adulto Jovem