Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 51
Filtrar
1.
Rev. Inst. Med. Trop ; 18(1)jun. 2023.
Artigo em Espanhol | LILACS-Express | LILACS | ID: biblio-1449259

RESUMO

Las vacunas previenen millones de muertes cada año y su eficacia y seguridad han sido ampliamente establecidas. En términos económicos, la vacunación es una de las intervenciones sanitarias más costo efectivas, generando un importante ahorro y crecimiento económico que supone a largo plazo. Se ha demostrado que la vacunación de adultos disminuye la morbilidad y la mortalidad asociadas a enfermedades infecciosas prevenibles, reduciendo las complicaciones y las hospitalizaciones, incluidos los ingresos a las unidades de cuidados intensivos. Hemos elaborado este documento de consenso con el objeto de diseñar un esquema de vacunación pragmático, accesible y estandarizado del adulto, según categoría de riesgo y edad, sobre la base de la evidencia disponible de vacunas accesibles y nuevas vacunas habiendo utilizado el Tercer Consenso de la Sociedad Paraguaya de Infectología del 2019 como base para las recomendaciones finales.


SUMMARY Vaccines prevent millions of deaths each year, and their efficacy and safety have been widely established. In economic terms, vaccination is one of the most cost-effective health interventions, generating significant savings and long-term economic growth. Adult vaccination has been shown to decrease morbidity and mortality associated with preventable Infectious diseases, reducing complications and hospitalizations, including admissions to intensive care units. We have prepared this consensus document in order to design a pragmatic, accessible and standardized vaccination scheme for adults, according to risk category and age, based on the available evidence of available vaccines and new vaccines, having used the third consensus of the Paraguayan Infectious Diseases Society of 2019 as a basis for the final recommendations.

2.
Nanomaterials (Basel) ; 13(6)2023 Mar 16.
Artigo em Inglês | MEDLINE | ID: mdl-36985962

RESUMO

Free cyanide is a highly dangerous compound for health and the environment, so treatment of cyanide-contaminated water is extremely important. In the present study, TiO2, La/TiO2, Ce/TiO2, and Eu/TiO2 nanoparticles were synthesized to assess their ability to remove free cyanide from aqueous solutions. Nanoparticles synthesized through the sol-gel method were characterized by X-ray powder diffractometry (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), Fourier-transformed infrared spectroscopy (FTIR), diffuse reflectance spectroscopy (DRS), and specific surface area (SSA). Langmuir and Freundlich isotherm models were utilized to fit the adsorption equilibrium experimental data, and pseudo-first-order, pseudo-second-order, and intraparticle diffusion models were used to fit the adsorption kinetics experimental data. Cyanide photodegradation and the effect of reactive oxygen species (ROS) on the photocatalytic process were investigated under simulated solar light. Finally, reuse of the nanoparticles in five consecutive treatment cycles was determined. The results showed that La/TiO2 has the highest percentage of cyanide removal (98%), followed by Ce/TiO2 (92%), Eu/TiO2 (90%), and TiO2 (88%). From these results, it is suggested that La, Ce, and Eu dopants can improve the properties of TiO2 as well as its ability to remove cyanide species from aqueous solutions.

3.
Psych J ; 12(3): 355-367, 2023 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-36740455

RESUMO

External sources of information influence human actions. However, psychological traits (PTs), considered internal variables, also play a crucial role in decision making. PTs are stable across time and contexts and define the set of behavioral repertoires that individuals express. Here, we explored how multiple metrics of adaptive behavior under uncertainty related to several PTs. Participants solved a reversal-learning task with volatile contingencies, from which we characterized a detailed behavioral profile based on their response sequences. We then tested the relationship between this multimetric behavioral profile and scores obtained from self-report psychological questionnaires. The PT measurements were based on the Hierarchical Taxonomy Of Psychopathology (HiTOP) model. By using multiple linear regression models (MLRMs), we found that the learning curves predicted important differences in the PTs and task response times. We confirmed the significance of these relationships by using random permutations of the predictors of the MLRM. Therefore, the behavioral profile configurations predicted the PTs and served as a "fingerprint" to identify participants with a high certainty level. We discuss briefly how this characterization and approach could contribute to better nosological classifications.


Assuntos
Reforço Psicológico , Reversão de Aprendizagem , Humanos , Reversão de Aprendizagem/fisiologia , Adaptação Psicológica , Incerteza
4.
MHSalud ; 19(2)dic. 2022.
Artigo em Espanhol | LILACS, SaludCR | ID: biblio-1405530

RESUMO

Resumen Objetivo: Comparar la composición corporal por antropometría clásica e impedancia bioeléctrica en estudiantado universitario de una universidad peruana. Método: Estudio correlacional, transversal, conformado por 152 estudiantes (77 varones y 75 mujeres) matriculados en el ciclo 2018-II con edad promedio de 20.45 ± 3.63 años. Se calculó para el método de antropometría el índice de masa corporal, mediciones antropométricas y se utilizó la ecuación de Yuhasz (1974) para determinar el porcentaje de grasa corporal, y para el de bioimpedancia eléctrica se utilizó el analizador tetrapolar multifrecuencia de medición segmental directa Inbody 120. Para establecer la correlación se utilizó el coeficiente de Pearson y para la concordancia se utilizó el método gráfico de Bland Altman e índice de estabilidad. Los datos fueron analizados con el programa estadístico IBM SPSS Statistics, versión 27.0. Para todos los análisis se utilizó un nivel de significancia (p<0.05). Resultados: Existe una fuerte correlación estadísticamente significativa (p<0.01y r=0.95) entre los métodos de antropometría y bioimpedancia eléctrica para la determinación del porcentaje de grasa corporal; además, una buena concordancia según el método gráfico de Bland Altman, reforzada con el índice de estabilidad para complemento de la interpretación (IE= 95 %). Conclusiones: Ambos métodos son intercambiables entre sí, por lo que pueden ser usados indistintamente en este tipo de población para determinar el porcentaje de grasa corporal expresado en porcentaje.


Abstract Objective: The aim was to compare the body composition using classical anthropometry and bioelectric impedance in university students of a Peruvian university. Method: a correlational, cross-sectional study with a research sample of 152 students (77 men and 75 women) enrolled in the 2018-II period with an average age of 20.45 ± 3.63 years. The body mass index and anthropometric measurements were calculated for the anthropometric method. The Yuhasz (1974) equation was used to determine the body fat percentage. The electrical bioimpedance method implemented the tetrapolar multi-frequency direct segmental measurement analyzer Inbody 120. Pearson coefficient was used to establish the correlation, and the Bland Altman graphical method and stability index were used for concordance. The data were analyzed using the statistical software application IBM SPSS Statistics, version 27.0. A level of significance (p <0.05) was used for all analyzes. Results: there is a strong statistically significant correlation (p<0.01 and r = 0.95) between the anthropometric and electrical bioimpedance methods to determine body fat percentage. In addition, there is a good agreement according to the Bland Altman graphical method, reinforced by the stability index to complement the interpretation (IE = 95%). Conclusions: Both methods are interchangeable with each other, so they can be used indistinctly in this type of population to determine body fat percentage.


Resumo Objetivo: comparar a composição corporal por antropometria clássica e impedância bioelétrica em estudantes universitários de uma universidade peruana. Método: estudo correlacional, transversal, compreendendo 152 estudantes (77 homens e 75 mulheres) matriculados no ciclo 2018-II, com idade média de 20,45 ± 3,63 anos. Para o método antropométrico, o índice de massa corporal, as medidas antropométricas e a equação de Yuhasz (1974) foram calculados para determinar a porcentagem de gordura corporal; e para o método de bioimpedância elétrica foi usado o analisador tetrapolar multifrequencial com medida segmentar direta Inbody 120. O coeficiente de Pearson foi usado para estabelecer a correlação; o método gráfico Bland Altman e o índice de estabilidade foram usados para a concordância. Os dados foram analisados com o IBM SPSS Statistics, versão 27.0. Um nível de significância (p<0,05) foi usado para todas as análises. Resultados: há uma forte correlação estatística significativa (p<0,01 e r=0,95) entre os métodos de antropometria e bioimpedância elétrica para a determinação da porcentagem de gordura corporal; além disso, uma boa concordância de acordo com o método gráfico Bland Altman, reforçado com o índice de estabilidade para complementar a interpretação (IE= 95%). Conclusões: Ambos os métodos são intercambiáveis entre si, portanto, podem ser utilizados indistintamente nesse tipo de população para determinar a porcentagem de gordura corporal expressa como porcentagem.


Assuntos
Humanos , Masculino , Feminino , Adulto , Antropometria/instrumentação , Tecido Adiposo , Impedância Elétrica/uso terapêutico
5.
Immun Inflamm Dis ; 10(12): e736, 2022 12.
Artigo em Inglês | MEDLINE | ID: mdl-36444623

RESUMO

BACKGROUND: Probiotics in allergic rhinitis (AR) have shown improvement in clinical and quality of life scores, whereas the role of synbiotics in the treatment of AR has been poorly investigated. The purpose of this study was to evaluate the clinical efficacy of synbiotics in children with AR. METHODS: An observational, prospective cohort study of pediatric outpatients with AR from a private medical center in Peru (2021) was conducted. At baseline, patients who were prescribed synbiotics during routine and those who were not (controls) recruited and followed up on Days 30, 60, and 90 of follow-up. Clinical efficacy was assessed with differences in Visual Analogous Scale (VAS), Total Nasal Symptom Score (TNSS), Rhinitis Control Assessment Test (RCAT), and the Pediatric Rhinoconjunctivitis Quality of Life Questionnaire (PRQLQ) scores between groups at follow-up. Mean differences ± standard deviation (SD) and 95% confidence intervals (95% CI) are reported. RESULTS: Two hundred and fifteen participants were analyzed. Compared to controls (n = 115), those who used synbiotics (n = 100) had significantly lower VAS (mean difference 1.3; 95% CI: 0.8-1.8), TNSS (mean difference 1.1; 95% CI: 0.5-1.7) and higher RCAT scores and PRQLQ scores (mean difference 2.2; 95% CI: -3.3 to -1.2) and (mean difference 7.0; 95% CI: 3.1-10.9), respectively, at Day 90 of follow-up CONCLUSIONS: This paper reports significant improvement in clinical (VAS, RCAT, TNSS) and quality of life (PRQLQ) scores of small and large sizes, respectively. These preliminary findings support the need of future trials to assess the role of synbiotics in children with AR.


Assuntos
Rinite Alérgica , Simbióticos , Humanos , Criança , Qualidade de Vida , Peru , Estudos Prospectivos , Rinite Alérgica/epidemiologia , Rinite Alérgica/terapia , Resultado do Tratamento , Estudos de Coortes
6.
Sci Rep ; 11(1): 6533, 2021 03 22.
Artigo em Inglês | MEDLINE | ID: mdl-33753782

RESUMO

Neuropsychological tests (targeting cognitive, linguistic, motor, and executive abilities) are grouped in neuropsychological domains that are thought to be stable through adulthood. However, this assumption does not always hold true, particularly during young children's early developmental phase. Here, we explored how the neuropsychological profile of typical Spanish-speaking preschoolers varied and consolidated with age. We recruited 643 monolingual Latin-American children from Mexico, Colombia, and Guatemala, with ages spanning from 30 to 71 months of age, and applied a novel neuropsychological examination which combined a total of 52 tests covering five classical neuropsychological domains: receptive, expressive, attention/memory, processing, and executive functions. These tests' scores uncovered a correlational structure across neuropsychological functions that could not be explained by chance. Notably, these correlations' overall strength, but not their interdependence across domains, dramatically increased with age. Moreover, by applying conventional clustering techniques to classify the experimental data, we found a stable representation of two clusters of children with distinctive traits, with cultural factors contributing to this classification scheme. We also found that the tasks were well organized in a network of abilities, where nodes with highest highest interconnectedness were those that required multimodal processing. These results contribute to our understanding of children's 'normal' development and could help identify how failure in particular functions forecasts the emergence of neurodevelopmental disorders. Our analytic methods might become useful to characterize individual differences and improve educational practices and interventions.


Assuntos
Atenção/fisiologia , Função Executiva/fisiologia , Atividade Motora/fisiologia , Adulto , Criança , Pré-Escolar , Colômbia , Feminino , Guatemala , Humanos , América Latina/epidemiologia , Linguística , Masculino , México , Testes Neuropsicológicos
7.
J Med Entomol ; 58(1): 246-251, 2021 01 12.
Artigo em Inglês | MEDLINE | ID: mdl-33432352

RESUMO

A parasitic outbreak caused by dermanyssoid mites in a herpetarium of the Metropolitan area of the Valley of Mexico is revealed. This outbreak was caused by Hemilaelaps triangulus (Ewing), but a second mite species, Ophionyssus natricis (Gervais), was found in low abundance. The parasitic load is analyzed, and the morphological and molecular diagnostic characters to identify each of the two species involved are given. A barcode analysis is presented, and two more molecular markers are presented and analyzed. Hemilaelaps triangulus is recorded for the first time in Mexico, and this is the first record of massive infestation on captive snakes caused by ixodorhynchid mites, and DNA sequences of ixodorhynchid mites are publicly available for the first time.


Assuntos
Surtos de Doenças/veterinária , Infestações por Ácaros/veterinária , Ácaros/classificação , Serpentes , Animais , México/epidemiologia , Infestações por Ácaros/classificação , Infestações por Ácaros/epidemiologia , Infestações por Ácaros/parasitologia , Ácaros/anatomia & histologia , Ácaros/genética , Ácaros/fisiologia
8.
Cambios rev. méd ; 19(2): 44-48, 2020-12-29. tabs., graf.
Artigo em Espanhol | LILACS | ID: biblio-1179358

RESUMO

INTRODUCCIÓN. La fractura de cuello de fémur constituye un problema de salud a nivel mundial, siendo complicación frecuente la infección de vías urinarias en adultos mayores. OBJETIVO. Determinar las variables demográficas e identificar las principales complicaciones infecciosas pre y posquirúrgicas en adultos mayores con fractura de cuello de fémur. MATERIALES Y MÉTODOS. Estudio observacional, descriptivo y retrospectivo, con una población igual a la muestra de 310 datos de Historias Clínicas, de pacientes hospitalizados en la Unidad de Traumatología y Ortopedia del Hospital de Especialidades Carlos Andrade Marín durante el periodo abril 2018 a febrero 2019. Criterios de inclusión: mayores de 65 años de edad, con diagnóstico prequirúrgico de fractura de cuello de fémur. Criterios exclusión: menores de 65 años con fractura patológica de cuello de fémur. Los datos fueron tomados del sistema AS400, la tabulación y análisis se realizó en los programas estadísticos Microsoft Excel e International Business Machines Statistical Package for the Social Sciences, versión 20. RESULTADOS. Las complicaciones fueron las infecciones: vías urinarias 14,19% (44; 310), tracto respiratorio inferior 3,23 % (10; 310) y menos común la de tracto respiratorio superior 0,33% (1; 310). DISCUSIÓN. Este estudio encontró a las infecciones de vías urinarias como primera causa de complicación en la artroplastia total de cadera, similar a otras investigaciones en Latinoamérica. CONCLUSIÓN. Se identificó a la infección de vías urinarias como usual en pacientes pre y posquirúrgicos de fractura de cuello de fémur, mientras que menos frecuente fue la infección de tracto respiratorio superior en las prequirúrgica y la sepsis en las posquirúrgicas.


INTRODUCTION. The femoral neck fracture constitutes a health problem worldwide, with urinary tract infection being a frequent complication in older adults. OBJECTIVE. To determine the demographic variables and identify the main infectious complications before and after surgery in older adults with a femoral neck fracture. MATERIALS AND METHODS. Observational, descriptive and retrospective study, with a population equal to the sample of 310 data from Medical Records, of hospitalized patients in the Traumatology and Orthopedics Unit of the Carlos Andrade Marín Specialty Hospital during the period april 2018 to february 2019. Inclusion criteria: people over 65 years of age, with a pre-surgical diagnosis of a femoral neck fracture. Exclusion criteria: under 65 years old with pathological fracture of the femoral neck. The data were taken from the AS400 system, the tabulation and analysis was carried out in the statistical programs Microsoft Excel and International Business Ma- chines Statistical Package for the Social Sciences, version 20. RESULTS. Complications were infections: urinary tract 14,19% (44; 310), lower respiratory tract 3,23% (10; 310) and the less common upper respiratory tract 0,33% (1, 310). DISCUSSION. This study found urinary tract infections as the first cause of complication in total hip arthroplasty, similar to other investigations in Latin America. CONCLUSION. Urinary tract infection was identified as usual in pre and postoperative femoral neck fracture patients, while upper respiratory tract infection was less frequent in preoperative and sepsis in postoperative.


Assuntos
Humanos , Masculino , Feminino , Idoso , Idoso de 80 Anos ou mais , Ortopedia , Infecções Urinárias , Idoso , Geriatria , Fraturas do Quadril , Hospitalização , Artroplastia , Sistema Urinário , Traumatologia , Fraturas Ósseas , Colo do Fêmur , Quadril
9.
Front Behav Neurosci ; 14: 99, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32760255

RESUMO

The contribution of non-sensory information processing to perceptual decision making is not fully understood. Choice biases have been described for mice and humans and are highly prevalent even if they decrease rewarding outcomes. Choice biases are usually reduced by discriminability because stimulus strength directly enables the adjustments in the decision strategies used by decision-makers. However, choice biases could also derive from functional asymmetries in sensory processing, decision making, or both. Here, we tested how particular experimental contingencies influenced the production of choice biases in mice and humans. Our main goal was to establish the tasks and methods to jointly characterize psychometric performance and innate side-choice behavior in mice and humans. We implemented forced and un-forced visual tasks and found that both species displayed stable levels of side-choice biases, forming continuous distributions from low to high levels of choice stereotypy. Interestingly, stimulus discriminability reduced the side-choice biases in forced-choice, but not in free-choice tasks. Choice biases were stable in appearance and intensity across experimental days and could be employed to identify mice and human participants. Additionally, side- and alternating choices could be reinforced for both mice and humans, implying that choice biases were adaptable to non-visual manipulations. Our results highlight the fact that internal and external elements can influence the production of choice biases. Adaptations of our tasks could become a helpful diagnostic tool to detect aberrant levels of choice variability.

10.
Rev Peru Med Exp Salud Publica ; 37(1): 57-62, 2020.
Artigo em Espanhol, Inglês | MEDLINE | ID: mdl-32520193

RESUMO

In order to determine the profile of sensitization to aeroallergens in pediatric patients with asthma and / or allergic rhinitis, a cross-sectional study was carried out in 411 patients using an allergy skin test. Age, sex, total IgE level and eosinophils were analyzed. The mean age was 8.1 ± 3.7 years and 60.6% were male. The average of the eosinophils and the level of total IgE was 450.1 ± 377.3 cells / mm3 and 861.7 ± 757.6 IU / mL, respectively. Mites were the most frequent sensitizing allergens (79.8%) and Dermatophagoides farinae (65.2%) was the most common. Polysensitization was present in 76.2% of patients. Sensitization was evident in the majority of patients with asthma and / or allergic rhinitis and was associated with age, age groups and total IgE level.


Con el objetivo de determinar el perfil de sensibilización a aeroalérgenos en pacientes pediátricos con asma y/o rinitis alérgica se realizó un estudio transversal en 411 pacientes usando una prueba cutánea de alergia. Se analizó la edad, sexo, nivel de IgE total y eosinófilos. La edad media fue de 8,1 ± 3,7 años y el 60,6% fueron varones. La media de los eosinófilos y el nivel de IgE total fue de 450,1 ± 377,3 células/mm3 y 861,7 ± 757,6 IU/mL, respectivamente. Los ácaros fueron los alérgenos sensibilizantes más frecuentes (79,8%) y el Dermatophagoides farinae (65,2%) fue el más común. La polisensibilización estuvo presente en el 76,2% de los pacientes. La sensibilización se evidenció en la mayoría de los pacientes con asma y/o rinitis alérgica y estuvo asociada con la edad, grupos etarios y nivel de IgE total.


Assuntos
Alérgenos , Hipersensibilidade , Alérgenos/imunologia , Asma/epidemiologia , Criança , Pré-Escolar , Estudos Transversais , Feminino , Humanos , Hipersensibilidade/epidemiologia , Imunoglobulina E/sangue , Masculino , Peru/epidemiologia , Rinite Alérgica/epidemiologia , Testes Cutâneos
11.
Rev. peru. med. exp. salud publica ; 37(1): 57-62, ene.-mar. 2020. tab, graf
Artigo em Espanhol | LILACS | ID: biblio-1101811

RESUMO

RESUMEN Con el objetivo de determinar el perfil de sensibilización a aeroalérgenos en pacientes pediátricos con asma y/o rinitis alérgica se realizó un estudio transversal en 411 pacientes usando una prueba cutánea de alergia. Se analizó la edad, sexo, nivel de IgE total y eosinófilos. La edad media fue de 8,1 ± 3,7 años y el 60,6% fueron varones. La media de los eosinófilos y el nivel de IgE total fue de 450,1 ± 377,3 células/mm3 y 861,7 ± 757,6 IU/mL, respectivamente. Los ácaros fueron los alérgenos sensibilizantes más frecuentes (79,8%) y el Dermatophagoides farinae (65,2%) fue el más común. La polisensibilización estuvo presente en el 76,2% de los pacientes. La sensibilización se evidenció en la mayoría de los pacientes con asma y/o rinitis alérgica y estuvo asociada con la edad, grupos etarios y nivel de IgE total.


ABSTRACT In order to determine the profile of sensitization to aeroallergens in pediatric patients with asthma and / or allergic rhinitis, a cross-sectional study was carried out in 411 patients using an allergy skin test. Age, sex, total IgE level and eosinophils were analyzed. The mean age was 8.1 ± 3.7 years and 60.6% were male. The average of the eosinophils and the level of total IgE was 450.1 ± 377.3 cells / mm3 and 861.7 ± 757.6 IU / mL, respectively. Mites were the most frequent sensitizing allergens (79.8%) and Dermatophagoides farinae (65.2%) was the most common. Polysensitization was present in 76.2% of patients. Sensitization was evident in the majority of patients with asthma and / or allergic rhinitis and was associated with age, age groups and total IgE level.


Assuntos
Criança , Pré-Escolar , Feminino , Humanos , Masculino , Alérgenos , Hipersensibilidade , Peru/epidemiologia , Asma/epidemiologia , Imunoglobulina E/sangue , Testes Cutâneos , Alérgenos/imunologia , Estudos Transversais , Rinite Alérgica/epidemiologia , Hipersensibilidade/epidemiologia
12.
J Parasitol ; 105(1): 85-91, 2019 02.
Artigo em Inglês | MEDLINE | ID: mdl-30807728

RESUMO

A new species of chigger mites, Morelacarus uazi n. sp., parasitizing lizards of the species Sceloporus grammicus from Mazapil, Zacatecas, Mexico, is described and illustrated. This new taxon differs from other species of the genus by having a palpal claw with 4 subequal paired prongs, and it can be further distinguished by the combination of the following characters: presence of onychotriches and mastitarsala III, absence of mastitibiala III, subterminala I, and parasubterminala I, and the palpal setal formula B/B/BBb. Additionally, an identification key for the species of the genus Morelacarus is presented. The new species represents the seventh species assigned to the genus and the first species described from a Mexican lizard.


Assuntos
Lagartos/parasitologia , Infestações por Ácaros/veterinária , Trombiculidae/classificação , Animais , Larva/anatomia & histologia , Larva/classificação , Larva/ultraestrutura , México/epidemiologia , Microscopia Eletrônica de Varredura/veterinária , Infestações por Ácaros/epidemiologia , Infestações por Ácaros/parasitologia , Prevalência , Trombiculidae/anatomia & histologia , Trombiculidae/ultraestrutura
13.
Pers. bioet ; 22(1): 39-55, ene.-jun. 2018. graf
Artigo em Espanhol | LILACS, BDENF - Enfermagem, COLNAL | ID: biblio-955269

RESUMO

Resumen El siglo XX fue una centuria de grandes descubrimientos científicos y desarrollos tecnológicos en todas las áreas, pero en particular en lo relativo a la conquista del espacio. Durante anos, la bioética fue pensada en estrecha relación con la ética médica y el ámbito de problemas específicamente humanos, pero en los últimos tiempos su sentido se ha ido ampliando. El presente trabajo busca relacionar esta preocupación por una ciencia de la supervivencia con la existencia de la llamada basura espacial o chatarra espacial que orbita la Tierra, y que en un tiempo no conocido afectara pequeñas o grandes áreas de nuestro planeta. La basura espacial se ha convertido en una preocupación cada vez mayor, especialmente en los últimos anos, puesto que las colisiones a velocidades orbitales pueden producir aún más basura espacial en el proceso llamado síndrome de Kessler, o cascada de ablación, lo que perjudicaría el funcionamiento de los satélites, afectaría las misiones espaciales o pondría en riesgo la vida de los astronautas. También es probable que dicha basura se precipite sobre la Tierra, con efectos no claramente evaluados sobre la población humana. Aunque el problema suele aparecer tanto en textos científicos como en obras de ciencia-ficción, no ha sido considerado con la seriedad exigida para un riesgo real y no alejado de la vida cotidiana.


Abstract The twentieth century was a century of great scientific discoveries and technological developments in all areas, but particularly with regard to the conquest of space. The last stretch of the millennium also witnessed two world wars and the development of atomic weapons with enormous destructive power, which made doubt many of the possibilities for the future of life on earth. At the end of his life, Albert Einstein said: "The unleashed power of the atom has changed everything except our way of thinking. So we go to a catastrophe unparalleled". It is in this context of concern about the future of life on earth, Van Rensselaer Potter coined the term bioethics, understood as Global Bioethics, a science of survival should combine biological knowledge and human values. For years, bioethics was thought closely related to medical ethics and scope of specifically human problems, but in recent years its meaning has expanded in line with the foundational approach Potter of ethics as a bridge to survival life in general. This paper seeks to relate this concern for a science of survival with the existence of the so-called space debris or space junk orbiting Earth and that once unknown, affect small or large areas of our planet. The waste consists of things as varied as large remnants of old rockets and satellites, remnants of explosions, debris or rocket components such as dust and small particles of paint. Space debris, has become a growing concern, especially in recent years, since collisions at orbital velocities can be highly damaging to functioning satellites, produce even more space debris in the process called Kessler Syndrome or waterfall ablation, but the worst would be that such wastes rush to land with not clearly evaluated effects on the human population. To illustrate a recent case of their impact on astronauts and equipment, it is the fact that the International Space Station had to be reinforced to mitigate the damage from this danger. Although the problem usually occurs both in scientific texts and works of science fiction, however it has not been considered with the seriousness required for a real risk and not away from everyday life.


Resumo O século XX foi um período de grandes descobertas científicas e desenvolvimentos tecnológicos em todas as áreas, mas em particular no tocante à conquista do espaço. Durante anos, a bioética foi pensada em estreita relação com a ética médica e com o âmbito de problemas especificamente humanos. Porém, nos últimos tempos, seu sentido tem sido ampliado. O presente trabalho busca relacionar essa preocupação por uma ciência da sobrevivência com a existência do chamado "detrito espacial" (ou "lixo espacial") que orbita a Terra e que, em algum momento desconhecido, afetará pequenas ou grandes áreas do nosso planeta. Os detritos espaciais se converteram em uma preocupação cada vez maior, especialmente nos últimos anos, visto que as colisões em velocidades orbitais podem produzir ainda mais detritos espaciais no processo denominado "síndrome de Kessler", o que prejudicaria o funcionamento dos satélites, afetaria as missões espaciais ou colocaria em risco a vida dos astronautas. Também é provável que tais detritos se precipitem sobre a Terra com efeitos não claramente avaliados sobre a população humana. Ainda que o problema costume aparecer tanto em textos científicos quanto em obras de ficção científica, o tema não foi considerado com a seriedade exigida para um risco real e próximo da vida cotidiana.


Assuntos
Humanos , População , Ciência , Bioética , Astronautas , Sobrevivência
14.
Genet Test Mol Biomarkers ; 21(11): 698-704, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28994615

RESUMO

AIM: To investigate the relationships of polymorphisms in genes whose protein products are related in the metabolic pathway of folic acid, particularly MTRR A66G, RFC1 G80A, and MTHFR C677T and A1298C, and disease activity in Mexican patients with rheumatoid arthritis (RA) treated with methotrexate (MTX). MATERIALS AND METHODS: Sixty-eight patients with RA were included in the study who were being treated with MTX, either with or without other drugs. In addition to general data, disease activity was measured by the disease activity score 28 (DAS28). Single nucleotide polymorphisms (SNPs) genotyping was performed by allelic discrimination using real-time polymerase chain reaction. RESULTS: Differences in genotype (homozygotic or heterozygotic for each allele), allele distributions, and phenotype were not statistically different between the RA group and control populations. We did not find any association between the studied polymorphisms and disease activity nor with the intragroup variables (e.g., clinical activity, body mass index, and single- or combined-drug treatment) or between genetic markers; we also did not find any association within the RA group or between the RA group and control populations. CONCLUSION: Additional studies of more polymorphisms related to this or other metabolic pathways are required to determine the influence of genetics on disease activity in RA.


Assuntos
Artrite Reumatoide/genética , Ferredoxina-NADP Redutase/genética , Metilenotetra-Hidrofolato Redutase (NADPH2)/genética , Proteína de Replicação C/genética , Adulto , Idoso , Alelos , Etnicidade/genética , Feminino , Ferredoxina-NADP Redutase/metabolismo , Ácido Fólico/genética , Ácido Fólico/metabolismo , Frequência do Gene/genética , Genótipo , Humanos , Masculino , Metotrexato , Metilenotetra-Hidrofolato Redutase (NADPH2)/metabolismo , México , Pessoa de Meia-Idade , Fenótipo , Polimorfismo de Nucleotídeo Único/genética , Proteína de Replicação C/metabolismo
15.
Rev. luna azul ; (44): 334-347, ene.-jun. 2017. ilus
Artigo em Espanhol | LILACS | ID: biblio-902054

RESUMO

Objetivos: Revisar la normatividad de residuos peligrosos en Colombia, su aplicabilidad y reglamentación, en un departamento pequeño que tiene una reducida generación, con el fin de identificar los vacíos existentes y la aplicabilidad de la política ambiental nacional, así como un análisis DOFA en la aplicabilidad de la normatividad de residuos peligrosos en el departamento del Quindío, comprobando la gestión integral y sus implicaciones. Metodología: La revisión incluyó la revisión de la comprensión de la normatividad, así como la bibliografía usada en la formulación de la política, los casos exitosos en otros países y la realización de encuestas en el trabajo de campo a los generadores de residuos, con lo cual se obtuvo la información necesaria para evaluar la aplicación de la Política Nacional en el departamento del Quindío. Resultados: Se visibilizaron las realidades de los generadores de residuos peligrosos en los cinco municipios del Quindío frente a la normativa ambiental y la Política Nacional, se encontró que la normativa nacional excluye a este sector, toda vez que hace exigencias que son difíciles de cumplir, por tanto no se aplica la norma. Discusión: Actualmente, no se promueve a nivel regional y nacional, la gestión de residuos peligrosos ni las opciones que faciliten el cumplimiento de las normas específicas, sin poner en riesgo la sustentabilidad ambiental, la sostenibilidad económica y social de los generadores de residuos peligrosos en los cinco municipios del Quindío. Conclusiones: Como producto de la investigación, se propone un modelo de gestión de residuos peligrosos, con dos variables dependiendo del volumen y características de los residuos generados, que incluye el ajuste normativo, la asociatividad de los generadores, una modificación del marco tarifario (con base en la regulación de los parámetros críticos de recolección y transporte), y el acompañamiento de los sectores comprometidos con la sostenibilidad ambiental, principalmente con la capacitación, formación ambiental y fortalecimiento técnico referido al manejo de los residuos o desechos peligrosos (líquidos, gaseosos, sólidos), orgánicos (que pueden tener procesos de compostaje) e inorgánicos (que pueden ser utilizados como reciclado o reutilizados como logística reversa o inversa) y los inservibles. Existe un gran desafío para un país, en especial cuando éste se enmarca en compromisos de convenios internacionales, al no tener en cuenta la heterogeneidad de las regiones, en cuanto a las capacidades de gestión y eliminación adecuada de residuos.


Objectives: To review the regulations for hazardous waste in Colombia, its applicability and regulation, in a small Department that has a reduced generation in order to identify gaps, and the applicability of the national environmental policy, as well as a DAFO analysis in the applicability of the regulations of hazardous waste in the department of Quindío, checking integrated management and its implications. Methodology: The revision included a review of the understanding of the regulations, as well as the literature used in the formulation of the policy, the successful cases in other countries and surveys to waste generators in the field work, with the purpose of obtaining the information needed to evaluate the implementation of the National Policy in the Department of Quindío. Results: The realities of hazardous waste generators became visible in the five municipalities of Quindío against the environmental regulations and the National Policy. It was found that the national legislation excludes this sector since it makes demands that are difficult to fulfill, therefore the rule is not applied. Discussion: Currently, management of hazardous waste or options to facilitate the achievement of specific standards without compromising environmental, economic and social sustainability of the generators of hazardous waste in the five municipalities of Quindío is not promoted at the regional and national level. Conclusions: As a result of the research, a model of hazardous waste management is proposed with two variables depending on the volume and characteristics of waste generated including regulatory setting, the association of the generators, a modification of the rate structure (based on the regulation of critical collection and transport parameters), and the accompaniment of the sectors committed to environmental sustainability, mainly through training, environmental education and technical strengthening relative to the handling of residues or hazardous waste (liquid, gaseous, solids), organic (which may have composting processes) and inorganic (which can be used as recycled or reused as reverse or inverse logistics) and unusable. There is a great challenge for a country, especially when it is part of commitments to international conventions, when it does not take into account the heterogeneity of the regions in terms of management skills and proper waste disposal.


Assuntos
Humanos , Política , Resíduos Perigosos , Gerenciamento de Resíduos , Política Ambiental
16.
Rev. luna azul ; 45: [150]-[170], 2017.
Artigo em Espanhol | LILACS | ID: biblio-997425

RESUMO

Con base en trabajos de carácter cualitativo y con enfoque de investigación acción participación IAP, se diseñó y se pusieron en funcionamiento varias obras arquitectónicas en Manizales, Marquetalia, Pácora, Pensilvania, Samaná y Chinchiná (Caldas), no solo de beneficio urbanístico, sino ambiental y social. Se logró que las comunidades se involucraran y participaran de manera integral a través de sus familias, lo cual garantizó la pertenencia y el cuidado posterior, logrando a su vez, muy buenas relaciones entre ellos y las diferentes entidades que apoyaron el proyecto.


Several architectural constructions, based on work of a qualitative nature and applying an action research approach IAP, were designed and put into operation in Manizales, Marquetalia, Pácora, Pensilvania, Samaná and Chinchiná (Caldas) not only for the urban benefit, but also for the environmental and social benefit. It was possible for communities to become involved and participate in a comprehensive manner through their families which guaranteed the sense of belonging and the subsequent care, achieving in turn very good relations between the community and the different entities that supported the project.


Assuntos
Participação da Comunidade , Conservação dos Recursos Naturais
17.
Rev. luna azul ; (43): 171-202, jul.-dic. 2016. ilus, tab
Artigo em Espanhol | LILACS | ID: biblio-830547

RESUMO

En Barrancominas (Guainía, Colombia) las diferentes formas culturales de trabajo y producción de la comunidad Piapoco, incluyen la tumba y quema de bosques a orillas del río, para ampliación de frontera agrícola, establecimiento de cultivos ilícitos y potreros; lo cual contribuye en el aumento de las concentraciones de carbono en la atmósfera que, a la vez, repercute en el cambio climático global. En consecuencia, el presente estudio quiso estimar el contenido de biomasa, fijación de carbono y los servicios ambientales, en un área de bosque primario en el Resguardo Indígena Chigüiro-Chátare, empleando una metodología no destructiva. Se estimó tanto la biomasa aérea, como el contenido de carbono (C) del estrato arbóreo del bosque por hectárea y la tasa de producción de hojarasca de las especies maderables: Mure, Pendare y Arenillo blanco. La biomasa aérea fue estimada a partir de los parámetros medidos en campo como altura y DAP y densidades de la madera de cada especie. Además, se analizó la dominancia de las especies para de esta forma conocer la representatividad del aporte de biomasa aérea y contenido de carbono en el bosque.


In Barrancominas (Guainía) different cultural forms of work and production of the Piapoco community, includes the slash and burn of forest along the river, to extend the farming, establishment of illicit crops and pastures contribute to increase carbon concentrations in the atmosphere which in turn affect global climate change. Thus this study wanted to value the biomass content, carbon fixation and ecosystem services in an area of primary forest in the indigenous community of Chigüiro-Chátare using a nondestructive method or indirect. In this study the aerial biomass was estimated as well as the carbon (C) content of the arboreal stratum of forest per hectare and production rate of dead leaves of three species forestry Mure, Pendare and Arenillo trees. The aerial biomass was estimated from the measured parameters in field such as: height, DAP and wood densities of each species. In addition, the species dominance was analyzed in order to know the representativeness of the biomass contribution and carbon content in the forest.


Assuntos
Humanos , Biomassa , Carbono , Florestas , Agricultura Florestal
18.
Rev. panam. salud pública ; 38(3): 217-225, Sep. 2015. ilus, tab
Artigo em Inglês | LILACS | ID: lil-766432

RESUMO

OBJECTIVE: To describe trends, geographic distribution, and risk factors for cesarean deliveries in Brazil in 2000-2011, and to determine if efforts to curtail rates have had a measurable impact. METHODS: This was an observational study using nationwide information from the Department of Informatics of the Unified Health System (DATASUS). Individual level analyses were based on data regarding maternal education, age, parity, and skin color. Ecological analyses at the level of 431 health districts investigated the relationships with health facility density and poverty level. RESULTS: Cesarean rates increased markedly, from 37.9% in 2000 to 53.9% in 2011. Preliminary results from 2012 showed a rate of 55.8%, with the richest geographic areas showing the highest rates. Rates at the municipal level varied from 9%-96%. Cesareans were more common in women with higher education, white skin color, older age, and in primi- paras. In the ecological analyses, the number of health facilities per 1 000 population was strongly and positively correlated with cesarean rates, with an increase of 16.1 percentage points (95% Confidence Interval [95%CI] = 4.3-17.8) for each facility. An increase of 1 percentage point in the poverty rate was associated with a decline of 0.5 percentage point in cesarean rates (95%CI = 0.5-0.6). CONCLUSIONS: The strong associations with maternal education and health facility density suggest that the vast majority of cesareans are not medically indicated. A number of policies and programs have been launched to counteract this trend, but have had virtually no impact.


OBJETIVO: Describir las tendencias, la distribución geográfica, y los factores de riesgo de parto por cesárea en el Brasil durante el período del 2000 al 2011, y determinar si las iniciativas dirigidas a reducir las tasas de cesáreas han tenido una repercusión cuantificable. MÉTODOS: Se trata de un estudio de observación que utilizó información a escala nacional del Departamento de Informática del Sistema Unificado de Salud (DATASUS). Los análisis a nivel individual se basaron en datos sobre el nivel de formación materna, la edad, la paridad y el color de la piel. Se investigaron las relaciones con la densidad de establecimientos de salud y el nivel de pobreza mediante análisis ecológicos a nivel de 431 distritos de salud. RESULTADOS: Las tasas de cesáreas aumentaron notablemente, de 37,9% en el 2000 a 53,9% en el 2011. Los resultados preliminares del 2012 mostraron una tasa de 55,8%, con tasas más elevadas en las zonas geográficas más ricas. Las tasas a escala municipal variaron de 9 a 96%. Los partos por cesárea fueron más frecuentes en las mujeres blancas, en las que tenían un mayor nivel de formación, en las de mayor edad y en las primíparas. En los análisis ecológicos, el número de establecimientos de salud por 1 000 habitantes se correlacionó intensa y positivamente con la tasa de cesáreas, con un incremento de 16,1 puntos porcentuales (intervalo de confianza (IC) de 95% = 4,3-17,8) para cada establecimiento. Un aumento de un punto porcentual en la tasa de pobreza se asociaba con una disminución de medio punto porcentual en la tasa de cesáreas (IC de 95% = 0,5-0,6). CONCLUSIONES: Las intensas asociaciones con el nivel de formación materna y la densidad de establecimientos de salud indican que la mayor parte de las cesáreas no están indicadas médicamente. Se han puesto en marcha diversos programas y políticas dirigidos a contrarrestar esta tendencia, pero prácticamente no han tenido ninguna repercusión.


Assuntos
Fatores Socioeconômicos , Cesárea , Cesárea/estatística & dados numéricos , Saúde Materna
19.
Rev Panam Salud Publica ; 38(3),sept. 2015
Artigo em Inglês | PAHO-IRIS | ID: phr-10077

RESUMO

Objective. To describe trends, geographic distribution, and risk factors for cesarean deliveries in Brazil in 2000–2011, and to determine if efforts to curtail rates have had a measurable impact. Methods. This was an observational study using nationwide information from the Department of Informatics of the Unified Health System (DATASUS). Individual level analyses were based on data regarding maternal education, age, parity, and skin color. Ecological analyses at the level of 431 health districts investigated the relationships with health facility density and poverty level. Results. Cesarean rates increased markedly, from 37.9% in 2000 to 53.9% in 2011. Preliminary results from 2012 showed a rate of 55.8%, with the richest geographic areas showing the highest rates. Rates at the municipal level varied from 9%–96%. Cesareans were more common in women with higher education, white skin color, older age, and in primiparas. In the ecological analyses, the number of health facilities per 1 000 population was strongly and positively correlated with cesarean rates, with an increase of 16.1 percentage points (95% Confidence Interval [95%CI] = 4.3–17.8) for each facility. An increase of 1 percentage point in the poverty rate was associated with a decline of 0.5 percentage point in cesarean rates (95%CI = 0.5–0.6). Conclusions. The strong associations with maternal education and health facility density suggest that the vast majority of cesareans are not medically indicated. A number of policies and programs have been launched to counteract this trend, but have had virtually no impact.


Objetivo. Describir las tendencias, la distribución geográfica, y los factores de riesgo de parto por cesárea en el Brasil durante el período del 2000 al 2011, y determinar si las iniciativas dirigidas a reducir las tasas de cesáreas han tenido una repercusión cuantificable. Métodos. Se trata de un estudio de observación que utilizó información a escala nacional del Departamento de Informática del Sistema Unificado de Salud (DATASUS). Los análisis a nivel individual se basaron en datos sobre el nivel de formación materna, la edad, la paridad y el color de la piel. Se investigaron las relaciones con la densidad de establecimientos de salud y el nivel de pobreza mediante análisis ecológicos a nivel de 431 distritos de salud. Resultados. Las tasas de cesáreas aumentaron notablemente, de 37,9% en el 2000 a 53,9% en el 2011. Los resultados preliminares del 2012 mostraron una tasa de 55,8%, con tasas más elevadas en las zonas geográficas más ricas. Las tasas a escala municipal variaron de 9 a 96%. Los partos por cesárea fueron más frecuentes en las mujeres blancas, en las que tenían un mayor nivel de formación, en las de mayor edad y en las primíparas. En los análisis ecológicos, el número de establecimientos de salud por 1 000 habitantes se correlacionó intensa y positivamente con la tasa de cesáreas, con un incremento de 16,1 puntos porcentuales (intervalo de confianza (IC) de 95% = 4,3–17,8) para cada establecimiento. Un aumento de un punto porcentual en la tasa de pobreza se asociaba con una disminución de medio punto porcentual en la tasa de cesáreas (IC de 95% = 0,5–0,6). Conclusiones. Las intensas asociaciones con el nivel de formación materna y la densidad de establecimientos de salud indican que la mayor parte de las cesáreas no están indicadas médicamente. Se han puesto en marcha diversos programas y políticas dirigidos a contrarrestar esta tendencia, pero prácticamente no han tenido ninguna repercusión.


Assuntos
Cesárea , Parto Obstétrico , Prova de Trabalho de Parto , Fatores Socioeconômicos , Saúde da Criança , Saúde Materna , Cesárea , Parto Obstétrico , Prova de Trabalho de Parto , Fatores Socioeconômicos , Saúde Materno-Infantil , Brasil , Brasil
20.
Zootaxa ; 3972(1): 65-74, 2015 Jun 10.
Artigo em Inglês | MEDLINE | ID: mdl-26249482

RESUMO

A new genus and species Callopistiella atacamensis gen. nov. and sp. nov. (Acariformes: Pterygosomatidae) are described from Callopistes maculatus (Squamata: Teiidae) in Chile. In this species, both sexes are characterized by the hypostome without a velum, the chelicerae proximally globose and very thin distally, ending in a movable digit curved outward, the fixed cheliceral digit reduced to a membranous and sparsely serrate structure, presence of seta 2c, tarsus I with seta ft nude and 2 times longer than solenidion ω2; larvae have solenidion ω1 on tarsus I and tibia I without solenidion φ and moderate hypertrichy present around the genital area. Some biological aspects of this new species are discussed.


Assuntos
Lagartos/parasitologia , Infestações por Ácaros/veterinária , Ácaros/classificação , Distribuição Animal , Estruturas Animais/anatomia & histologia , Estruturas Animais/crescimento & desenvolvimento , Animais , Tamanho Corporal , Chile , Ecossistema , Feminino , Masculino , Infestações por Ácaros/parasitologia , Ácaros/anatomia & histologia , Ácaros/crescimento & desenvolvimento , Tamanho do Órgão
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA