RESUMO
We evaluated the associations between three common polymorphisms in the AGER gene and the risks of breast (BC) and lung (LC) cancer using meta-analysis. A systematic electronic search of the literature was conducted to identify all potential correlation studies in Embase, Web of Science, Cochrane Library, CINAHL, PubMed, CISCOM, China BioMedicine (CBM), and China National Knowledge Infrastructure (CNKI) databases. Five case-control studies that investigated the correlation of AGER gene polymorphisms with BC and LC were included in the meta-analysis, representing 4337 subjects. An increased frequency of the AGER rs1800625 T>C polymorphism was observed in patients with either BC or LC. We found that the frequencies of AGER rs1800624 T>A and rs2070600 G>A variants were positively related to the risks of BC and LC under allelic models, but that these relationships were not detected under dominant models. Disease-stratified results under allelic models demonstrated that the frequencies of the AGER rs1800625 T>C and rs2070600 G>A polymorphisms were positively correlated with the susceptibility to LC, while the same correlations were not found in BC. Further subgroup analysis by genotyping method indicated that the rs1800624 T>A variant was associated with increased risks of BC and LC under a dominant model in both non-polymerase chain reaction-restriction fragment length polymorphism (non-PCR-RFLP) and PCR-RFLP subgroups. In conclusion, these data indicated that common polymorphisms in the AGER gene might increase the risks of BC and LC.
Assuntos
Neoplasias da Mama/genética , Estudos de Associação Genética , Neoplasias Pulmonares/genética , Receptor para Produtos Finais de Glicação Avançada/genética , Alelos , Neoplasias da Mama/patologia , China , Feminino , Predisposição Genética para Doença , Genótipo , Humanos , Neoplasias Pulmonares/patologia , Polimorfismo de Nucleotídeo Único , Fatores de RiscoRESUMO
This study investigated geographic and pairwise distances among seven Chinese local and four introduced sheep populations via analysis of 26 microsatellite DNA markers. Genetic polymorphism was rich, and the following was discovered: 348 alleles in total were detected, the average allele number was 13.38, the polymorphism information content (PIC) of loci ranged from 0.717 to 0.788, the number of effective alleles ranged from 7.046 to 7.489, and the observed heterozygosity ranged from 0.700 to 0.768 for the practical sample, and from 0.712 to 0.794 for expected heterozygosity. The Wright's F-statistic of subpopulations within the total (FST) was 0.128, the genetic differentiation coefficient (GST) was 0.115, and the average gene flow (Nm) was 1.703. The phylogenetic trees based on the neighbor-joining method by Nei's genetic distance (DA) and Nei's standard genetic distance (DS) were similar. Sheep populations clustered into group 1 (Ta, M, L, H, O, G, and Q breeds) and group 2 (PD, WS, B, and T breeds). These results will have an important value applied and directive significance for sheep breeding in the future.