RESUMO
The scientific publication landscape is changing quickly, with an enormous increase in options and models. Articles can be published in a complex variety of journals that differ in their presentation format (online-only or in-print), editorial organizations that maintain them (commercial and/or society-based), editorial handling (academic or professional editors), editorial board composition (academic or professional), payment options to cover editorial costs (open access or pay-to-read), indexation, visibility, branding, and other aspects. Additionally, online submissions of non-revised versions of manuscripts prior to seeking publication in a peer-reviewed journal (a practice known as pre-printing) are a growing trend in biological sciences. In this changing landscape, researchers in biochemistry and molecular biology must re-think their priorities in terms of scientific output dissemination. The evaluation processes and institutional funding for scientific publications should also be revised accordingly. This article presents the results of discussions within the Department of Biochemistry, University of São Paulo, on this subject.
Assuntos
Bioquímica , Biologia Molecular , Publicações Periódicas como Assunto/estatística & dados numéricos , Editoração/tendências , Pesquisa , Brasil , Humanos , Publicações Periódicas como Assunto/normas , Publicações Periódicas como Assunto/tendênciasRESUMO
The scientific publication landscape is changing quickly, with an enormous increase in options and models. Articles can be published in a complex variety of journals that differ in their presentation format (online-only or in-print), editorial organizations that maintain them (commercial and/or society-based), editorial handling (academic or professional editors), editorial board composition (academic or professional), payment options to cover editorial costs (open access or pay-to-read), indexation, visibility, branding, and other aspects. Additionally, online submissions of non-revised versions of manuscripts prior to seeking publication in a peer-reviewed journal (a practice known as pre-printing) are a growing trend in biological sciences. In this changing landscape, researchers in biochemistry and molecular biology must re-think their priorities in terms of scientific output dissemination. The evaluation processes and institutional funding for scientific publications should also be revised accordingly. This article presents the results of discussions within the Department of Biochemistry, University of São Paulo, on this subject.
Assuntos
Humanos , Publicações Periódicas como Assunto/estatística & dados numéricos , Editoração/tendências , Pesquisa , Bioquímica , Biologia Molecular , Publicações Periódicas como Assunto/normas , Publicações Periódicas como Assunto/tendências , BrasilRESUMO
Bradykinin-potentiating peptides (BPPs) or proline-rich oligopeptides (PROs) isolated from the venom glands of Bothrops jararaca (Bj) were the first natural inhibitors of the angiotensin-converting enzyme (ACE) described. Bj-PRO-5a (Assuntos
Inibidores da Enzima Conversora de Angiotensina/farmacologia
, Bothrops
, Venenos de Crotalídeos/farmacologia
, Domínios Proteicos Ricos em Prolina/fisiologia
, Receptor B2 da Bradicinina/fisiologia
, Receptor Muscarínico M1/fisiologia
, Vasodilatação/efeitos dos fármacos
, Inibidores da Enzima Conversora de Angiotensina/química
, Inibidores da Enzima Conversora de Angiotensina/isolamento & purificação
, Animais
, Células CHO
, Cricetinae
, Cricetulus
, Venenos de Crotalídeos/química
, Venenos de Crotalídeos/isolamento & purificação
, Relação Dose-Resposta a Droga
, Células HEK293
, Humanos
, Masculino
, Camundongos
, Camundongos Endogâmicos BALB C
, Vasodilatação/fisiologia
RESUMO
Bradykinin-potentiating peptides (BPPs) or proline-rich oligopeptides (PROs) isolated from the venomglands of Bothrops jararaca (Bj) were the first natural inhibitors of the angiotensin-converting enzyme(ACE) described. Bj-PRO-5a (Assuntos
Camundongos
, Oligopeptídeos/análise
, Oligopeptídeos/antagonistas & inibidores
, Venenos de Serpentes/análise
, Bothrops
, Drogas em Investigação/análise
, Drogas em Investigação/uso terapêutico
, Receptores Muscarínicos/análise
, Receptores Muscarínicos/biossíntese
, Receptores Muscarínicos/uso terapêutico