Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros











Base de dados
Intervalo de ano de publicação
1.
Mem. Inst. Oswaldo Cruz ; 115: e190364, 2020. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1091242

RESUMO

Oral transmission of Chagas disease has been increasing in Latin American countries. The present study aimed to investigate changes in hepatic function, coagulation factor levels and parasite load in human acute Chagas disease (ACD) secondary to oral Trypanosoma cruzi transmission. Clinical and epidemiological findings of 102 infected individuals attended in the State of Pará from October 2013 to February 2016 were included. The most common symptoms were fever (98%), asthenia (83.3%), face and limb edema (80.4%), headache (74.5%) and myalgia (72.5%). The hepatic enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) of 30 ACD patients were higher compared with controls, and this increase was independent of the treatment with benznidazole. Moreover, ACD individuals had higher plasma levels of activated protein C and lower levels of factor VII of the coagulation cascade. Patients with the highest parasite load had also the most increased transaminase levels. Also, ALT and AST were associated moderately (r = 0.429) and strongly (r = 0.595) with parasite load respectively. In conclusion, the present study raises the possibility that a disturbance in coagulation and hepatic function may be linked to human ACD.


Assuntos
Animais , Masculino , Feminino , Adulto , Aspartato Aminotransferases/sangue , Proteína C/análise , Fator VIIa/análise , Doença de Chagas/fisiopatologia , Alanina Transaminase/sangue , Fígado/fisiopatologia , Brasil/epidemiologia , Biomarcadores/sangue , Estudos de Casos e Controles , Doença Aguda , Estudos Prospectivos , Doença de Chagas/enzimologia , Doença de Chagas/sangue , Doença de Chagas/transmissão , Carga Parasitária , Fígado/enzimologia , Pessoa de Meia-Idade
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA