Assuntos

Fator Estimulador de Colônias de Granulócitos/efeitos adversos , Leucemia Mieloide Aguda/induzido quimicamente , Neutropenia/complicações , Agranulocitose/complicações , Agranulocitose/congênito , Cromossomos Humanos Par 7 , Humanos , Monossomia , Neutropenia/congênito , Proteínas Recombinantes/efeitos adversos , Síndrome

RESUMO

Absolute neutropenia lasting longer than 72 hours after birth occurred in four very low birth weight neonates with a maternal history of severe pregnancy-induced hypertension, and was treated with recombinant granulocyte colony-stimulating factor for 3 days. Absolute neutrophil counts increased nearly four-fold within 48 hours; maximal values were recorded on the ninth day after the infusion was started. Total leukocyte counts subsequently decreased but remained in the normal range. It appears that recombinant human granulocyte colony-stimulating factor promotes a rapid increase in circulating neutrophils in these patients despite the possible presence of a circulating preeclampsia-associated inhibitor of neutrophil production.

Assuntos

Fator Estimulador de Colônias de Granulócitos/uso terapêutico , Recém-Nascido de Baixo Peso , Neutropenia/terapia , Feminino , Humanos , Recém-Nascido de Baixo Peso/sangue , Recém-Nascido , Contagem de Leucócitos , Masculino , Neutropenia/etiologia , Neutrófilos , Pré-Eclâmpsia , Gravidez , Proteínas Recombinantes/uso terapêutico