RESUMO

A mass spectrometric study of the photooxidation products of the ophthalmic drugs pindolol (1-[1H-indol-4-yloxyl]-3-[isopropylamino]-2-propanol) and timolol (S-[-]-1-[t-butylamino]-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxyl]-2-propanol) in water has been performed by LC-MS. Based on these data and the assumption that photooxidation mainly occurs through singlet molecular oxygen attack, a possible reaction mechanism is proposed. The mechanistic pathways involve singlet oxygen attack to the pindolol indole ring and oxidation of the pindolol isopropyl or timolol terbutyl methyl groups.

Assuntos

Antagonistas Adrenérgicos beta/análise , Pindolol/análise , Timolol/análise , Cromatografia Líquida de Alta Pressão , Peso Molecular , Soluções Oftálmicas , Oxirredução , Fotoquímica , Fotólise , Controle de Qualidade , Espectrometria de Massas por Ionização por Electrospray