RESUMO
Lichen sclerosus is a chronic inflammatory mucocutaneous disease, rarely involving the mouth. There are only 20 well-documented cases of oral lichen sclerosus reported in the English-language literature. This report describes the clinicopathological features of 6 cases of oral lichen sclerosus; 5 in women. There were 12 lesions, mainly on the lips (50%) and buccal mucosa (25%). The affected areas appeared as irregular whitish patches, harder than the surrounding tissue. Half of the patients were symptomatic and presented with no associated skin and/or genital lesions. All cases were biopsied, and histopathological features were evaluated using hematoxylin-eosin and Verhoeff's stains, S-100 immunohistochemical reaction and transmission electron microscopy. Management of the oral lesions consisted of surgical excision, intralesional triamcinolone acetonide, oral colchicine, and regular follow-up. There is no effective curative treatment, but there are some options for patient management; and colchicine may be considered an additional choice.
Assuntos
Líquen Escleroso e Atrófico/patologia , Doenças da Boca/patologia , Administração Oral , Adolescente , Adulto , Anti-Inflamatórios/administração & dosagem , Anti-Inflamatórios/uso terapêutico , Biópsia , Criança , Colchicina/administração & dosagem , Colchicina/uso terapêutico , Diagnóstico Diferencial , Feminino , Seguimentos , Glucocorticoides/administração & dosagem , Glucocorticoides/uso terapêutico , Humanos , Imuno-Histoquímica , Injeções Intralesionais , Líquen Escleroso e Atrófico/tratamento farmacológico , Líquen Escleroso e Atrófico/cirurgia , Doenças Labiais/tratamento farmacológico , Doenças Labiais/patologia , Doenças Labiais/cirurgia , Masculino , Microscopia Eletrônica de Transmissão , Doenças da Boca/tratamento farmacológico , Doenças da Boca/cirurgia , Mucosa Bucal/patologia , Estudos Retrospectivos , Proteínas S100/análise , Doenças da Língua/tratamento farmacológico , Doenças da Língua/patologia , Doenças da Língua/cirurgia , Resultado do Tratamento , Triancinolona Acetonida/administração & dosagem , Triancinolona Acetonida/uso terapêutico , Adulto JovemRESUMO
A quantification method for measuring whole saliva is described. This whole saliva test (WST) consists of a Whatman paper strip, is easily carried out, innocuous, low-cost and single use. Due to its characteristics, it could be considered as the oral equivalent of Schirmer's tear test. A sample of 159 healthy subjects (81 males and 78 females; mean age 31.62 years) participated in this comparative study of this new procedure and two other tests, the draining and the swab test. Correlation was statistically positive among the three types of tests.