RESUMO
A therapeutical clinical trial was designed to study the effectiveness of Paico and Albendazole, for the treatment of ascariasis in a group of 60 children, between 3 and 14 years old, from a rural community in Huaraz. It was carried out between May and August, 2000. The sample was randomly divided into 30 cases for Paico and 30 for Albendazole, the criteria for entering the trial being a positive examination for Ascaris lumbricoides in feces. The treatment consisted in Paico juice: 1 ml/Kg for less than 10 Kg, and 2 ml/Kg in larger children, one dose before breakfast, for three consecutive days. The Albendazole was administered in a single dose of 400 mg in those over five years of age, and 200 mg in younger children. The effectiveness was evaluated qualitatively (the disappearance of the ascaris eggs from the feces) and quantitatively (decrease in the parasitic burden); in the stool examinations carried out in all cases on entering the study and 15 days after the treatment. All the stool samples were processed in the Referential Laboratory of the Regional Health Authority in Ancash. The qualitative effectiveness between Paico and Albendazole for the eradication of ascariasis was similar at 86.7%. The quantitative effectiveness was 59.5% for Paico and 58.3% for Albendazole. However, it was observed that, unlike Albedazole, Paico is 100% effective in the treatment of Hymenolepsis nana. Adverse effects were presented in 23.3% of the cases for both drugs. It is concluded that, although Paico and Albendazole have a similar effectiveness against Ascaris lumbricoides, Paico has the additional benefit of being effective against Hymenolepsis nana.
Assuntos
Albendazol/uso terapêutico , Anti-Helmínticos/uso terapêutico , Ascaridíase/tratamento farmacológico , Chenopodium ambrosioides , Fitoterapia , Óleos de Plantas/uso terapêutico , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Masculino , PeruRESUMO
One hundred and fifteen patients with upper gastrointestinal bleeding diagnosed, between august 1992 and july 1995, at the "Victor Ramos Guardia" General Hospital in Huaraz (3,100 m.o.s.l.), Ancash, Perú, are here studied to know about epidemiologics and clinical aspects of this condition at high altitude. In all, the patients on upper endoscopy were done and gastric biopsy when it was required. The incidence of upper gastrointestinal bleeding for the population at risk was 9.6/ 10,000 in habitants by year, and the institutional prevalence was 12.3/1,000 hospital discharges. All the patients were native from the sierra of Ancash, 55.7% males, 37.4% older than 60 years at age; mean age 52.2 years (18 = 86), 50.4% admitted ingestion of gastroerosives, 55.7% presented with hematemesis and melena, 34.4% only melena, 41.7% had hemoglobin less than 8g/dl and 66.3% required or blood transfusion. The most frequent causes of upper gastrointestinal bleeding were gastric ulcer (29.6%), gastric cancer (26.1%), duodenal ulcer (17.4%), erosions (6.1%). No cause was detected in 7%. The endoscopy diagnostic certainty was 93%. 84.3% required medical treatment, 15.7% required surgical treatment and the global mortality was 4.3%. Attention is made on the high frequency of gastric ulcer and gastric carcinoma as the source of upper gastro intestinal bleeding, in the Indian population.