Assuntos
Amicacina/farmacologia , Antibacterianos/farmacologia , Gentamicinas/farmacologia , Doenças do Recém-Nascido/induzido quimicamente , Canamicina/análogos & derivados , Sulfato de Magnésio/efeitos adversos , Doenças Neuromusculares/induzido quimicamente , Tobramicina/farmacologia , Adolescente , Animais , Sinergismo Farmacológico , Feminino , Humanos , Recém-Nascido , Doenças do Recém-Nascido/terapia , Intubação Intratraqueal , Masculino , Camundongos , Camundongos Endogâmicos , Doenças Neuromusculares/terapia , Coelhos , Insuficiência Respiratória/induzido quimicamente , Insuficiência Respiratória/terapiaRESUMO
To investigate the effects on the newborn infant of maternal magnesium therapy for treatment of pre-eclampsia, we studied 36 hypermagnesemic infants born to pre-eclamptic mothers treated with MgSO4, 18 neonates born to untreated pre-eclamptic mothers, and 25 infants born to normal mothers. Impairment of neuromuscular transmission, as well as neurobehavioral differences when compared to controls, were found in hypermagnesemic infants. Awareness of the changes produced in the neonate by magnesium is important for accurate clinical assessment of the infant's condition, as well as for anticipating the postnatal interaction of magnesium with other drugs administered during labor and delivery.
Assuntos
Doenças do Recém-Nascido/induzido quimicamente , Sulfato de Magnésio/efeitos adversos , Hipotonia Muscular/induzido quimicamente , Pré-Eclâmpsia/tratamento farmacológico , Tetania/induzido quimicamente , Adulto , Cálcio/sangue , Feminino , Humanos , Recém-Nascido , Doenças do Recém-Nascido/fisiopatologia , Magnésio/sangue , Hipotonia Muscular/fisiopatologia , Exame Neurológico , Potássio/sangue , Gravidez , Sódio/sangue , Tetania/fisiopatologiaRESUMO
A retrospective study of ten patients with infant botulism who received gentamicin or kanamycin suggests that aminoglycoside antibiotics potentiate muscular weakness and precipitate respiratory failure as late as 27 days after onset of the disease. Although it is difficult to separate progression of the disease from the effects of antibiotics, the rapidity of deterioration following aminoglycoside treatment and the rapidity of recovery following cessation of aminoglycoside therapy is highly suggestive. A review of five patients who received only penicillin or a semisynthetic derivative of penicillin did not reveal any temporal deterioration with onset of penicillin therapy or improvement with cessation of penicillin therapy.