RESUMO
BACKGROUND AND OBJECTIVES: The purpose of the study was to register antibody prevalences of HHV-7 in various locations of the world in comparison to the closely related HHV-6. MATERIALS AND METHODS: Sera of healthy blood donors from nine countries in five continents were titered by indirect immunofluorescent assays using HHV-6 infected HSB2 and HHV-7 infected SupT1 cells. RESULTS: Antibody prevalence for HHV-7 is high (75-98%) in practically all countries except for Northern Japan (44%), with no simple correlation to elevated HHV-6 antibody titers. There were regions of low, intermediate and high mean antibody titers against HHV-7 such as 78.5-91.3 for Belgium, Israel, Japan, USA and Australia, 175.4-182.6 for Mexico and Cologne/Germany, and 389.2 for South Africa for which geographic characteristics may be responsible. CONCLUSION: HHV-7, similar to HHV-6, is a widespread human herpesvirus with elevated antibody titers in the healthy human population essentially everywhere. The data warrant further studies to evaluate its possible pathologic potential, preferentially in persons with defective immune responses.
Assuntos
Anticorpos Antivirais/sangue , Doadores de Sangue , Infecções por Herpesviridae/epidemiologia , Herpesvirus Humano 6/imunologia , Herpesvirus Humano 7/imunologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Austrália/epidemiologia , Bélgica/epidemiologia , Feminino , Alemanha/epidemiologia , Infecções por Herpesviridae/virologia , Humanos , Recém-Nascido , Israel/epidemiologia , Japão/epidemiologia , Masculino , México/epidemiologia , Pessoa de Meia-Idade , Polônia/epidemiologia , Estudos Soroepidemiológicos , África do Sul/epidemiologia , Estados Unidos/epidemiologiaRESUMO
The human herpes virus 7 (HHV-7) has been recently isolated from CD4 cells of healthy persons. The present study describes the antibody prevalence of this virus in a healthy Mexican population. Two hundred blood samples from candidates for blood donation at the Hospital General de Mexico were studied with the indirect immunofluorescence test (IFA) in HHV-7 infected SupT1 cells. The testing was done in the University of Cologne, Germany; 167 were males and 33 female; the donors came from 12 of the 31 states in the Mexican republican, predominantly from Mexico City (60.5%) and the State of Mexico (28%). Their mean age was 29.2 years. All but three samples were positive to the HHV-7 (98.5% positivity). Nearly 85% had high titers (> or = 1:80). Other serology testing in the samples revealed 1% positive tests to hepatitis B, 2% to syphilis, and 0.5% to brucella. Hepatitis C and the HIV test were negative in all. The high prevalence of HHV-7 in our donor population should be further studied in order to determine titers indicative of an active infection and of their association with illnesses.
Assuntos
Anticorpos Antivirais/sangue , Doadores de Sangue , Infecções por Herpesviridae/epidemiologia , Herpesvirus Humano 7/isolamento & purificação , Adulto , Anticorpos Antivirais/imunologia , Feminino , Técnica Indireta de Fluorescência para Anticorpo , Infecções por Herpesviridae/sangue , Herpesvirus Humano 6/imunologia , Herpesvirus Humano 6/isolamento & purificação , Herpesvirus Humano 7/imunologia , Humanos , Masculino , México/epidemiologia , Pessoa de Meia-Idade , Prevalência , Estudos SoroepidemiológicosRESUMO
Human herpesvirus 7 (HHV-7) has been recently isolated from CD4-positive peripheral blood lymphocytes of a healthy person. The present study was performed to find the antibody prevalence of this virus in the healthy Mexican population. Two hundred blood samples from candidates for blood donation at the General Hospital of Mexico were studied with the indirect immunofluorescence test (IFA) in HHV-7 infected SupT1 cells. 83.5% were male persons and 16.5% female, the mean age for the male group was 28.8 years and for the female group 31.5. The donors came from 12 different states in Mexico, predominantly from the city (60.8%), and had different occupations. Almost all samples (98.5%) were positive to HHV-7. Other studies done revealed 1% positive to brucella, 1% positive to Hepatitis B, 2% positive to syphilis, hepatitis C and HIV test were negative in the whole group studied. There was a high incidence of HHV-7 in the group studied: more than 50% of the subject had high titers. This results should be further studied determine titers indicative of an active infection and to search for any association with illnesses.
Assuntos
Doadores de Sangue/estatística & dados numéricos , Etnicidade/estatística & dados numéricos , Infecções por Herpesviridae/etnologia , Herpesvirus Humano 7/isolamento & purificação , Adulto , Bancos de Sangue , Linfócitos T CD4-Positivos/virologia , Estudos Transversais , Feminino , Imunofluorescência , Infecções por Herpesviridae/transmissão , Humanos , Incidência , Masculino , México/epidemiologia , Valores de Referência , Fatores de RiscoRESUMO
Urological and nephrological investigations were done on 100 diabetics and 21 controls. 77 percent of the diabetics were found to have vesical dysfunction. 58 percent of those with dysfunction also had decreased renal function. Evidence was produced in support of the theory that ascending urinary tract infection is a contributary factor in decreasing renal function in diabetics (AU)