RESUMO

The synthesis of new chiral seleno-, telluro-, and thio-N-Boc-γ-amino acids is described herein. These new compounds were prepared through a simple and short synthetic route, from the inexpensive and commercially-available amino acid L-glutamic acid. The products, with a highly modular character, were obtained in good to excellent yields, via hydrolysis of chalcogen pyroglutamic derivatives with overall retention of the L-glutamic acid stereochemistry. Also, an L-diselenide-N-Boc-γ-amino acid was prepared in good yield. This new synthetic route represents an efficient method for preparing new L-chalcogen- and L-diselenide-γ-amino acids with biological potential.

Assuntos

Ácidos Carboxílicos/síntese química , Calcogênios/síntese química , Compostos Organosselênicos/síntese química , Compostos de Sulfidrila/síntese química , Aminoácidos/síntese química , Aminoácidos/química , Ácidos Carboxílicos/química , Calcogênios/química , Estrutura Molecular , Compostos Organosselênicos/química , Compostos de Sulfidrila/química