RESUMO
Se describe un nuevo método para cuantificar la captación relativa del ventrículo derecho en los estudios de perfusión miocárdica. Se demuestra que el índice de captación propuesto está en relación con el grado de isquemia miocárdica en el ventrículo izquierdo.
A new method for quantification of relative right ventricular uptake in myocardial perfusion Studies is described. A direct relationship between the proposed uptake index and the degree of left ventricular myocardial ischemia is demonstrated.
Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Circulação Coronária , Função Ventricular Direita/fisiologia , Imagem de Perfusão do Miocárdio , Isquemia Miocárdica , Isquemia Miocárdica/fisiopatologia , Tomografia Computadorizada de Emissão de Fóton Único , Distribuição Tecidual , Compostos RadiofarmacêuticosRESUMO
INTRODUCTION: Changes in regional cerebral blood flow (rCBF) have been reported in idiopathic Parkinson's disease (PD). Nonetheless, their typical pattern still remains controversial regarding some features, such as basal ganglia involvement and the main cortical regions affected. Functional neuroimaging makes it possible to identify the brain dysfunctions of the neural circuits underlying the disease. Voxel-based analysis methods make it possible to increase the reliability of the results. OBJECTIVE: To assess the rCBF changes in patients with PD and their relation with disease duration. MATERIALS AND METHODS: Thirty PD adult patients without dementia underwent evaluation with (99m)Tc-ECD SPECT. SPM5 was used for statistical comparison with 25 normal controls of similar ages. The disease course duration in years was added as a covariate. Additionally, patients with a 6-year evolution or less and those with more than 6 years were compared separately with normal controls. RESULTS: Significant hypoperfusion was detected in bilateral premotor and posterior parietal cortex and increase of perfusion was present in the cerebellum. These changes correlated with the years of evolution of the illness. Patients with longer evolution also presented thalamic, subthalamic and basal ganglia hypoperfusion. CONCLUSIONS: We describe rCBF changes in PD in neural circuits related with control of movements. These changes are more manifest in patients with a longer duration of the disease.