RESUMO

One of the mechanisms of action of non steroid antiinflammatory drugs (NSAIDs) consists of inhibition of prostaglandin synthesis. This explains many of the pharmacological effects and adverse events observed in medical practice. Administration of NSAIDs to patients with hemostatic disorders or perioperative conditions entails the risk of bleeding due to inhibition of platelet function. This study deals with platelet changes induced by lysine clonixinate vs diclofenac, ibuprofen and aspirin in classical tests such as platelet count, platelet factor 3 (PF3) activity and platelet aggregation with various inductors and more recent procedures such as P-selectin measurement by flow cytometry. Unlike control drugs, lysine clonixinate did not induce changes in platelet count or function when administered to healthy volunteers at the commonly used therapeutic doses.

Assuntos

Anti-Inflamatórios não Esteroides/farmacologia , Plaquetas/efeitos dos fármacos , Clonixina/análogos & derivados , Clonixina/antagonistas & inibidores , Lisina/análogos & derivados , Lisina/antagonistas & inibidores , Agregação Plaquetária/efeitos dos fármacos , Adulto , Análise de Variância , Aspirina/farmacologia , Clonixina/administração & dosagem , Diclofenaco/farmacologia , Citometria de Fluxo , Humanos , Ibuprofeno/farmacologia , Lisina/administração & dosagem , Masculino , Selectina-P , Contagem de Plaquetas , Testes de Função Plaquetária

RESUMO

One of the mechanisms of action of non steroid antiinflammatory drugs (NSAIDs) consists of inhibition of prostaglandin synthesis. This explains many of the pharmacological effects and adverse events observed in medical practice. Administration of NSAIDs to patients with hemostatic disorders or perioperative conditions entails the risk of bleeding due to inhibition of platelet function. This study deals with platelet changes induced by lysine clonixinate vs diclofenac, ibuprofen and aspirin in classical tests such as platelet count, platelet factor 3 (PF3) activity and platelet aggregation with various inductors and more recent procedures such as P-selectin measurement by flow cytometry. Unlike control drugs, lysine clonixinate did not induce changes in platelet count or function when administered to healthy volunteers at the commonly used therapeutic doses.