RESUMO
Both juvenile (14-16 week) and adult (18 month) Ambystoma mexicanum reject skin allografts from adult Ambystoma more speedily than they reject such grafts from juvenile axolotls. Donor-specific histocompatibility antigen, prepared from splenocytes, is more effective in inhibiting adult host splenocyte migration when the antigen is prepared from spleen cells from adult, rather than from juvenile Ambystoma. The thymus is fully developed in juvenile Ambystoma, suggesting that the delayed kinetics of rejection of juvenile allografts reflects immaturity in the expression of histocompatibility antigens to donor skin cells.
Assuntos
Ambystoma mexicanum/imunologia , Ambystoma/imunologia , Antígenos de Histocompatibilidade , Fatores Etários , Animais , Inibição de Migração Celular , Feminino , Rejeição de Enxerto , Masculino , Transplante de Pele , Baço/imunologia , Timo/crescimento & desenvolvimento , Timo/imunologia , Transplante HomólogoAssuntos
Nitrobenzenos/imunologia , Timectomia , Timo/imunologia , Trinitrobenzenos/imunologia , Ambystoma mexicanum , Animais , Formação de Anticorpos , Soro Antilinfocitário/farmacologia , Sítios de Ligação , Galinhas , Eritrócitos/imunologia , Feminino , Haptenos/imunologia , Cavalos , Masculino , Linfócitos T/imunologiaRESUMO
Juvenile and mature neotenous Ambystoma mexicanum received allogeneic and xenogeneic skin transplants. Rejection times for 1st-set, and 3rd-set grafts were noted at 21 degrees C, and for axolotls placed in a cold-room at 7 degrees C 7 h post-grafting, 1 week post-grafting and 2 weeks post-grafting respectively. In all cases graft-rejection was chronic; 2nd and 3rd-set grafts were rejected progressively more rapidly than 1st-set grafts. An important temperature-sensitive event occurs during the 1st week post-grafting.