RESUMO
Experimental transplantation of embryonic nervous cells in the central nervous system demonstrates that these precursor cells can be used to repair damaged cells in neurodegenerative diseases. However, the use of cells from embryos is still controversial and alternative ethically accepted sources are needed to overcome the inherent problems. Several sources have been proposed such as bone marrow cells, olfactory bulb cells and astrocytes. We suggest the use of neuronal precursor cells from the nasal olfactory mucosa as an alternative source for transplantation therapy, since these peripheric cells exhibit stem cell characteristics.
Assuntos
Neurônios/transplante , Transplante de Células-Tronco , Sistema Nervoso Central/citologia , Humanos , Doenças Neurodegenerativas/cirurgia , Neurônios/fisiologia , Mucosa Olfatória/inervaçãoRESUMO
Experimental transplantation of embryonic nervous cells in the central nervous system demonstrates that these precursor cells can be used to repair damaged cells in neurodegenerative diseases. However, the use of cells from embryos is still controversial and alternative ethically accepted sources are needed to overcome the inherent problems. Several sources have been proposed such as bone marrow cells, olfactory bulb cells and astrocytes. We suggest the use of neuronal precursor cells from the nasal olfactory mucosa as an alternative source for transplantation therapy, since these peripheric cells exhibit stem cell characteristics.
RESUMO
This article is a bibliographic review concerning the scientific advances in nervous tissue transplantation in experimental animals and in humans as applied to neurodegenerative diseases, particularly Parkinson's disease. Data show the possibility that the transplantation of nervous tissue may alleviate the typical symptoms of some of these diseases. Since the first trials in 1890, there has been a remarkable progress in this field, encouraging the idea that nervous tissue transplantation may be considered in clinical practice.
Assuntos
Tecido Nervoso/transplante , Doenças Neurodegenerativas/cirurgia , Neurônios/transplante , Animais , Encéfalo/cirurgia , Humanos , Doença de Parkinson/cirurgia , Ratos , Transplante Heterólogo/métodosRESUMO
This article is a bibliographic review concerning the scientific advances in nervous tissue transplantation in experimental animals and in humans as applied to neurodegenerative diseases, particularly Parkinsons disease. Data show the possibility that the transplantation of nervous tissue may alleviate the typical symptoms of some of these diseases. Since the first trials in 1890, there has been a remarkable progress in this field, encouraging the idea that nervous tissue transplantation may be considered in clinical practice.