Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros











Base de dados
Intervalo de ano de publicação
1.
Theor Popul Biol ; 154: 94-101, 2023 12.
Artigo em Inglês | MEDLINE | ID: mdl-37742787

RESUMO

Multiple-merger coalescents, also known as Λ-coalescents, have been used to describe the genealogy of populations that have a skewed offspring distribution or that undergo strong selection. Inferring the characteristic measure Λ, which describes the rates of the multiple-merger events, is key to understand these processes. So far, most inference methods only work for some particular families of Λ-coalescents that are described by only one parameter, but not for more general models. This article is devoted to the construction of a non-parametric estimator of the density of Λ that is based on the observation at a single time of the so-called Site Frequency Spectrum (SFS), which describes the allelic frequencies in a present population sample. First, we produce estimates of the multiple-merger rates by solving a linear system, whose coefficients are obtained by appropriately subsampling the SFS. Then, we use a technique that aggregates the information extracted from the previous step through a kernel type of re-construction to give a non-parametric estimation of the measure Λ. We give a consistency result of this estimator under mild conditions on the behavior of Λ around 0. We also show some numerical examples of how our method performs.


Assuntos
Genética Populacional , Modelos Genéticos , Frequência do Gene , Densidade Demográfica
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA