RESUMO
La clindamicina es un antibiótico de amplio espectro con actividad contra los aerobios grampositivos y una extensa gama de bacterias anaerobias, entre ellas los patógenos productores de betalactamasa. Los estudios in vitro e in vivo han demostrado que este fármaco alcanza una concentración elevada en el punto de infección, reduce la virulencia de las bacterias y refuerza las actividades fagocíticas de los linfocitos inmunitarios del huésped. La clindamicina por vía oral se absorbe con rapidez y eficacia, y su concentración permanece por encima de la concentración inhibidora mínima de la mayoría de los organismos por lo menos durante 6 horas. En este análisis, presentaremos pruebas de la eficacia e inocuidad de la clindamicina en el tratamiento de las infecciones odontogénicas con datos de estudios preclínicos y clínicos, los cuales avalan la aplicación general de este antibiótico como antiinfeccioso en el campo de la odontología.
Clindamycin is an antibiotic of wide range of action with a great activity against aerobic gram-positive germs and a broad spectrum of anaerobic bacteria, among which we can find the pathogenic agents that produce Beta-lactamase. The in vitro and in vivo have shown that this medicine reaches a high concentration at the infection point, reduces the bacteria virulence, and strengthens the phagocytic activity of the immunizing lymphocyte of the host. Clindamycin through oral ingestion is absorbed very quickly and effectively, and its concentration remains the same above the minimum inhibitory concentration of most of the organisms at least for six hours. In this analysis, we will introduce some proofs about the effectiveness and innocuousness of clindamycin in the treatment of odontogenic infections. This data is based upon clinical and pre-clinical studies that support the general use of this mentioned antibiotic as an anti-infectious agent in the field of odontology.
Assuntos
Clindamicina/farmacologia , Clindamicina/uso terapêutico , Infecção Focal Dentária/diagnóstico , Infecção Focal Dentária/terapia , Ampicilina/uso terapêutico , Doenças Periodontais/terapia , Relatório de Pesquisa , Penicilina V/uso terapêutico , Profilaxia Dentária , Interpretação Estatística de DadosRESUMO
The goal of this study was to determine if the Community Periodontal Index and Treatment Need (CPITN) screening method can detect an adolescent group at high risk for alveolar bone due to periodontitis. Forty-five Jamaican children, aged 13 years, with a pocket depth exceeding 3.5 mm on at least on index tooth were identified by CPITN for this cohort study. Current periodontal disease was noted by the presence of bleeding upon probing (97.8 percent) and subgingival calculus (41.5 percent) around the index teeth. Digital imaging software was used to analyze the radiographs and indicated alveolar bone loss greater than 2 mm in 93.3 of subjects and greater than 3 mm in 42.2 percent. The CPITN screening method was shown to be valuable as a tool for identifying this high-risk population (AU)
Assuntos
Adolescente , Humanos , Periodontite Agressiva , Índice Periodontal , Índice Periodontal , JamaicaRESUMO
The goal of this study was to determine if the Community Periodontal Index and Treatment Need (CPITN) screening method can detect an adolescent group at high risk for alveolar bone loss due to periodontitis. Forty-five Jamaican children, age 13 years, with a pocket depth exceeding 3.5mm on at least on index tooth were identified by CPITN for this cohort study. Current periodontal disease was noted by the presence of bleeding upon probing (97.8 percent) and subgingival calculus (41.5 percent) around the index teeth. Digital imaging software was used to analyze the radiographs and indicated alveolar bone loss greater than 2mm in 93.3 percent of subjects and greater than 3mm in 42.2 percent. The CPITN screening method was shown to be valuable as a tool for identifying this high-risk population.(AU)
Assuntos
Humanos , Adolescente , Doenças da Gengiva , Doenças da Polpa Dentária , Periodontite Agressiva , Testes de Atividade de Cárie Dentária , Materiais DentáriosRESUMO
A cohort study of forty-five Jamaican children, aged 13 years, was conducted to examine the periodontal findings of an epidemiology survey of the previous year. All subjects had, in the field survey, at least one index tooth probed to a depth exceeding 3.5 mm, indicating loss of epithelia attachment. A World Health Organization designed peridontal probe was used to assess sulcular bleeding, calculus and probing depth on six index teeth. Anterior and posterior teeth were radiographed. Active peridontal disease is indicated by the presence of bleeding upon probing (97.8 percent) and subgingival calculus (41.5 percent) in the sites with indicated loss of junctional epithelium. Digital imaging software used to analyse the radiographs indicated alveolar bone loss greater than 2 mm in 93.3 percent of subjects and greater than 3 mm in 42.2 percent. The insignificant difference (p=.08) between alveolar bone loss in molar versus premolar sites is strongly suggestive of a generalized form of periodontitis (AU)