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Introducción: la fibromialgia (FM) es un síndrome caracterizado por la presencia de dolor musculoesquelético crónico y generalizado, de origen no articular, que puede llegar a ser invalidante y afectar la esfera biológica, psicológica y social del paciente. Estado del arte: no se han publicado recomendaciones nutricionales específicas para las personas con FM y también existe un vago conocimiento acerca de los parámetros relacionados con la evaluación de la composición corporal (masa musculoesquelética, masa grasa, agua corporal, etc.) y la alteración en la fuerza muscular (p. ej., dinapenia, por dinamometría de mano, flexión de la rodilla, entre otras), así como la evaluación en términos de sarcopenia. Discusión: pocos estudios publicados hasta el momento describen en profundidad la composición corporal de las personas con FM. La mayoría se centran casi exclusivamente en la descripción del peso y el índice de masa corporal (IMC), por lo que existe poco conocimiento acerca de otros parámetros de relevancia, como por ejemplo aquellos relacionados con masa y fuerza muscular o masa grasa. La alimentación se menciona en varias publicaciones, pero no existen guías o pautas específicas de recomendaciones nutricionales para esta población. Algunos pacientes adoptan diversas dietas, estrategias o planes alimentarios sin ningún tipo de orientación de los profesionales de la salud, e incluso a veces, siguiendo fuentes de información no fiables, poniendo en riesgo su salud. Las publicaciones científicas no evalúan la asociación o el impacto del estado nutricional y la inadecuada alimentación en la calidad de vida. Conclusiones: en las personas con FM, conocer el estado nutricional, más allá del peso, determinando la composición corporal y la prevalencia de dinapenia o sarcopenia o ambas permitiría realizar un abordaje nutricional más adecuado. Este conocimiento podría ser coadyuvante en la terapéutica, logrando una mejoría en su desempeño físico y una mejor calidad de vida. (AU)

Introduction: fibromyalgia (FM) is a syndrome charcaterized by the presence of chronic, and generalized musculoskeletal pain, not articular in origin, which can become disabling and affect the biological, psychological, and social sphere of the patient. State of the art: no specific nutritional recommendations have been published for people with FM and there is also a vague knowledge regarding parameters related to body composition assessment (skeletal muscle mass, body fat mass, water, etc.) and loss of muscle strength (for example, dynapenia, by handgrip, knee flexion, among others), as well as assessment in terms of sarcopenia. Discussion: there are few studies published so far that completely describe the body composition in people with FM. Most of them focus almost exclusively on weight and body mass index (BMI), so there is a lack of knowledge about other descriptive parameters, such as those related to muscle mass and strength or fat mass. Diet is mentioned in several publications, but there are no specific guidelines for nutritional recommendations for this population. Some patients follow several diets, strategies or eating plans without health care professionals' guidance, and sometimes even following unreliable sources of information, putting themselves at risk. Scientific publications do not evaluate the association or impact of nutritional status and inadequate nutrition on quality of life in FM. Conclusions: in people with FM, knowledge of the nutritional status, beyond weight, determining body composition and the prevalence of dynapenia and/or sarcopenia would allow a more accurate nutritional approach. This knowledge could be helpful for the treatment, achieving an improvement in their physical performance and a better quality of life. (AU)

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La sarcopenia se define como una combinación de baja fuerza y masa muscular con alteración funcional del músculo, que afecta a poblaciones de diferentes edades por diversos motivos. La prevalencia global en adultos mayores se ha estimado en 10% (IC 95%: 8-12%) en hombres y 10% (IC 95%: 8-13%) en mujeres. Recientemente ha cobrado importancia su detección en enfermedades reumáticas, particularmente las inflamatorias. En esta revisión narrativa hemos considerado: a) recomendaciones para el diagnóstico de la sarcopenia; b) herramientas útiles para la práctica clínica y la investigación; c) su relación con las enfermedades reumáticas. Según el último Consenso Europeo de Sarcopenia la búsqueda debe comenzar cuando el paciente reporta síntomas y/o signos (debilidad, lentitud al caminar, desgaste muscular, pérdida de masa muscular, etc.). Para los adultos mayores se recomienda el cuestionario SARC-F como herramienta de tamizaje. Varias pruebas establecen los puntos de corte que deben utilizarse para diagnosticar la baja fuerza muscular, la disminución en la masa muscular y la alteración en el rendimiento físico. La relevancia de diagnosticar precozmente la sarcopenia se basa en el impacto clínico, económico y social que tiene, incluyendo la funcionalidad y calidad de vida de las personas, muy importante en aquellas con enfermedades reumatológicas.

Sarcopenia is defined as a combination of low muscle strength and mass with muscle function impairment that affects the population at different age ranges for different reasons. The global prevalence at the elderly was estimated at 10% (95% CI: 8-12%) in men and 10% (95% CI: 8-13%) in women. In recent years, the detection of sarcopenia in rheumatic diseases has become relevant. The aim of this revision was to develop a review regarding: a) recommendations for the diagnosis of sarcopenia; b) most useful tools for detection in clinical practice and research; c) relationship with some rheumatic diseases. According to the latest European Sarcopenia Consensus, in clinical practice, the search must start when the patient reports symptoms and signs (weakness, slow walking, muscle wasting, disease that leads to muscle loss, etc.). For the elderly population the SARC-F test is recommended as a screening tool. Several tests have established cut-off points to be used to diagnose low muscle strength, decrease in muscle mass or physical performance impairment. The relevance of early diagnosis of sarcopenia is based on the clinical, economic, social impact and also on functionality and quality of life in people, particularly in those with rheumatic diseases.

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Tan solo en los últimos 50 años, la esperanza de vida ha aumentado en más de 20 años. Este aumento significativo de la longevidad se debe en parte a los avances de la medicina, las intervenciones de salud pública, la biotecnología y el desarrollo social y económico, que han permitido a las personas vivir más que en cualquier otro momento de la historia. En América Latina y el Caribe, la proporción de personas de 60 o más años de edad aumentará incluso en 18% durante el próximo decenio y para el 2050 se ubicará entre 25% y 30% de la población. Esta transición ocurrirá en 35 años, que es tan solo la mitad del tiempo que requirió en Estados Unidos y Canadá.

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[EXTRACT]. In just the past 50 years, life expectancy has increased by more than 20 years. This significant increase in longevity is due in part to advances in medicine, public health interventions, biotechnology, and social and economic development that have made it possible for people to live longer than at any other time in history.

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Chronically reduced glomerular filtration rate (GFR) in old people does not always mean that they suffer from chronic kidney disease (CKD) since their GFR can just be reduced by aging. The HUGE equation has been recently described and validated in Spain for screening CKD without taking into account the patient's GFR value. This equation is based on patient's hematocrit, plasma urea levels and gender. The present study documented that the HUGE equation had and acceptable performance for screening CKD in elderly Argentine patients.

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Renal aging is frequently confused with chronic nephropathy in clinical practice, since there are some similarities between them, particularly regarding reduced glomerular filtration rate (GFR). However, there are many differences between these two entities which can help any practitioner to distinguish between them, such as: GFR deterioration rate, hematocrit, renal handling of urea, creatinine and some electrolytes, tubular acidification, urinalysis, and renal imaging. Differentiation between renal aging and chronic renal disease is crucial in order to avoid unnecessary medicalization of what is a physiological change associated with the healthy aging process, and the potential harmful consequences of such overdiagnosis. A recently described equation (HUGE), as well as an adequate nephrological evaluation and follow up can help physicians to distinguish both entities.

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Since evaluation of glomerular filtration rate (GFR) is very important in daily medical care, and reliable methods for measuring GFR are too complicated, there has been along decades an enormous effort for developing accurate GFR equations. In the present review article, we performed a comprehensive analysis of the mainly described GFR equations, and we concluded that although MDRD, CKD-EPI, DRA and Gregori-Macías equations are valid to monitor renal function as well as to stage and follow up renal patients, the clinical nephrological evaluation still remains the best alternative for diagnosing renal health and disease.

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Frailty is a construct originally coined by gerontologists to describe cumulative declines across multiple physiological systems that occur with aging and lead individuals to a state of diminished physiological reserve and increased vulnerability to stressors. Fried et al. provided a standardized definition for frailty, and they created the concept of frailty phenotype which incorporates disturbances across interrelated domains (shrinking, weakness, poor endurance and energy, slowness, and low physical activity level) to indentify old people who are at risk of disability, falls, institutionalization, hospitalization, and premature death. Some authors consider the presence of lean mass reduction (sarcopenia) as part of the frailty phenotype. The frailty status has been documented in 7 % of elderly population and 14 % of not requiring dialysis CKD adult patients. Sarcopenia increases progressively along with loss of renal function in CKD patients and is high in dialysis population. It has been documented that prevalence of frailty in hemodialysis adult patients is around 42 % (35 % in young and 50 % in elderly), having a 2.60-fold higher risk of mortality and 1.43-fold higher number of hospitalization, independent of age, comorbidity, and disability. The Clinical Frailty Scale is the simplest and clinically useful and validated tool for doing a frailty phenotype, while the diagnosis of sarcopenia is based on muscle mass assessment by body imaging techniques, bioimpedance analysis, and muscle strength evaluated with a handheld dynamometer. Frailty treatment can be based on different strategies, such as exercise, nutritional interventions, drugs, vitamins, and antioxidant agents. Finally, palliative care is a very important alternative for very frail and sick patients. In conclusion, since the diagnosis and treatment of frailty and sarcopenia is crucial in geriatrics and all CKD patients, it would be very important to incorporate these evaluations in pre-dialysis, peritoneal dialysis, hemodialysis, and kidney transplant patients in order to detect and consequently treat the frailty phenotype in these groups.

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BACKGROUND: Transient elastography (TE) is a useful tool for the assessment of hepatic fibrosis as an alternative to liver biopsy, but it has not been validated as a screening procedure in apparently healthy people. AIM: To determine the prevalence of advanced liver fibrosis diagnosed by TE in a socioeconomically challenged rural population. MATERIAL AND METHODS: We enrolled 299 participants aged over 18 years old from a vulnerable population in Mexico who responded to an open invitation. All participants had their history recorded and underwent a general clinical examination and a liver stiffness measurement, performed by a single operator according to international standards. RESULTS: Overall, 7.35% participants were found to be at high risk for cirrhosis. Three variables correlated with a risk for a TE measure ≥ 9 kPa and significant fibrosis: history of alcohol intake [7.95 vs. 92.04%, odds ratio (OR) 4.47, 95% confidence interval (CI) 1.45-13.78, P = 0.0167], body mass index (BMI) ≥ 30 kg/m2 (30.87 vs. 69.12%, OR 4.25, 95%CI 1.04-6.10, P = 0.049), and history of diabetes mellitus (14.87 vs. 85.12%, OR 2.76, 95%CI 1.002-7.63, P = 0.0419). In the multivariate analyses BMI ≥ 30 kg/m2 was the only significant risk factor for advanced liver fibrosis or cirrhosis (OR 2.54, 95%CI 1.02-6.3, P = 0.0460). CONCLUSION: TE could be useful as a screening process to identify advanced liver fibrosis in the general and apparently healthy population.

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INTRODUCTION: This study aimed to determine the dislocation and reoperation rate, functional outcomes, and the survival rate of the unique subset of very old but lucid and independent patients with hip fractures following a total hip arthroplasty (THA) and geriatric team-coordinated perioperative care. METHOD: Between 2000 and 2006, previously independent ambulatory patients ≥80 years old presenting with an intracapsular hip fracture were given THAs under the care of an integrated orthopedic surgery-geriatric service. Their fracture-related complications, ambulation, mental status, and survival were followed for 5 to 11 years postinjury. RESULTS: Five years postinjury, 57 (61.3%) patients of the original study group were living. In all, 3 (3.2%) patients had postoperative hip dislocations (and 2 patients had dislocation twice) and 2 reoperations were needed within the first postoperative month. There were no hip dislocations or reoperations after the first year. Radiographs obtained on 88% of the surviving patients at 5 years postoperatively showed that all remained unchanged from their immediate postoperative images. Nearly half of the patients were still able to ambulate as they did preoperatively and their mixed-model equation was statistically unchanged. CONCLUSION: This study of patients >80 years old with previously good functional status demonstrates that with appropriate surgical (best prosthesis, good operating technique, and regional anesthesia) and geriatric (pre- and postoperative assessments, close follow-up, medication adjustments, and fall-prevention instruction) care, they have few hip dislocations and reoperations, survive postfracture at least as long as their noninjured contemporaries, and continue to function and ambulate as they did prior to their injury.

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Zenker's diverticulum (ZD), also known as cricopharyngeal, pharyngoesophageal or hypopharyngeal diverticulum, is a rare condition characterized by an acquired outpouching of the mucosal and submucosal layers originating from the pharyngoesophageal junction. This false and pulsion diverticulum occurs dorsally at the pharyngoesophageal wall between the inferior pharyngeal constrictor and the cricopharyngeus muscle. The pathophysiology of ZD involves altered compliance of the cricopharyngeus muscle and raised intrabolus pressure. Decreased compliance of the upper esophageal sphincter and failure to open completely for effective bolus clearance both lead to an increase in the hypopharyngeal pressure gradient. Different open surgical techniques and transoral endoscopic approaches have been described for the management of ZD, although there is no consensus about the best option. We report the case of a 61-year-old patient with a 7-year history of dysphagia and odynophagia for solid food, which after 2 months progressed to dysphagia for liquids and after 4 months to regurgitation 2-6 h after meals. The patient experienced a 12-kg weight loss. Diagnosis was established by esophagogram, which showed a diverticulum through the posterior pharyngeal wall, suggestive of a ZD. Esophagogastroduodenoscopy showed a pouch with erythematous mucosa. Under general anesthesia, diverticulectomy and myotomy were performed. After an uneventful recovery and adequate oral intake, the patient remains free of symptoms at 4 months of follow-up.

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Human senescence induces changes in the renin-angiotensin-aldosterone system (RAAS) which consists of a substantial decrease in its plasma activity. Consequently, the distal tubule´s capability of handling sodium and potassium is significantly reduced in the elderly, while distal tubule acidification is slightly delayed but preserved in this age group. Several studies in animal models support the hypothesis that senile renal structural changes could be induced by the local production of angiotensin II, and also that enalapril significantly decreases senile mesangial expansion, glomerulosclerosis and peritubular and medullar interstitial sclerosis. The same applies to several highly prevalent diseases in the elderly, such as hypertension, obesity, cardiac insufficiency, chronic nephropathy and dementia. In conclusion, the relationship between the RAAS and senescence is complex, since not only does aging cause many changes on this hormonal system, but also RAAS overactivity seems to be one of the main inducing mechanisms for normal senescence, and for many prevalent diseases in the elderly.

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La sarcopenia se define como la pérdida progresiva y gradual de la masa, la función y la fuerza del músculo esquelético que se presenta durante elproceso del envejecimiento. Todavía está en discusión hasta qué punto se puede considerar como un efecto deletéreo propio de la edad o como unsíndrome geriátrico con repercusiones clínicas, daño funcional e incapacidad. Lo que es realmente fundamental es que la pérdida de la masa muscularesquelética contribuye a un mayor riesgo de discapacidad física, fragilidad, pérdida de la independencia, pobre calidad de vida, incremento en los costos para el cuidado de la salud y aumento en la tasa de mortalidad de las personas envejecidas. Su etiología es compleja y multifactorial.Recientemente diversos grupos de trabajo han centrado su interés en la investigación en el área de la sarcopenia, debido a las consecuencias que tiene en la salud y funcionalidad del adulto mayor. El objetivo de esta revisión es examinar la información disponible sobre la conceptualización, definición y métodos de diagnóstico de la sarcopenia. Se mencionan los métodos de determinación de la masa muscular esquelética por técnicas de imagen como la resonancia magnética y la absorciometría dual de energía de rayos X (DXA). Se considera su estimación a través de análisis de impedancia bioeléctrica y de ecuaciones de predicción. Se mencionan los puntos de corte que se han utilizado con mayor frecuencia para el diagnóstico de sarcopenia y, asimismo, se muestra su prevalencia en diversos estudios epidemiológicos y las propuestas de tratamientos actuales.

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La sarcopenia se define como la pérdida progresiva y gradual de la masa, la función y la fuerza del músculo esquelético que se presenta durante elproceso del envejecimiento. Todavía está en discusión hasta qué punto se puede considerar como un efecto deletéreo propio de la edad o como unsíndrome geriátrico con repercusiones clínicas, daño funcional e incapacidad. Lo que es realmente fundamental es que la pérdida de la masa muscularesquelética contribuye a un mayor riesgo de discapacidad física, fragilidad, pérdida de la independencia, pobre calidad de vida, incremento en los costos para el cuidado de la salud y aumento en la tasa de mortalidad de las personas envejecidas. Su etiología es compleja y multifactorial.Recientemente diversos grupos de trabajo han centrado su interés en la investigación en el área de la sarcopenia, debido a las consecuencias que tiene en la salud y funcionalidad del adulto mayor. El objetivo de esta revisión es examinar la información disponible sobre la conceptualización, definición y métodos de diagnóstico de la sarcopenia. Se mencionan los métodos de determinación de la masa muscular esquelética por técnicas de imagen como la resonancia magnética y la absorciometría dual de energía de rayos X (DXA). Se considera su estimación a través de análisis de impedancia bioeléctrica y de ecuaciones de predicción. Se mencionan los puntos de corte que se han utilizado con mayor frecuencia para el diagnóstico de sarcopenia y, asimismo, se muestra su prevalencia en diversos estudios epidemiológicos y las propuestas de tratamientos actuales.(AU)

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El término fragilidad ha evolucionado a lo largo del tiempo, conceptualizándolo como ôriesgoõ de morir, de perder funcio- nes, de enfermar, asociado a debilidad, caídas, desnutrición. Distintas definiciones han incluido aspectos físicos, cognitivos y psicosociales. El debate acerca de la definición se centra en si deben o no asociarse factores psicosociales. La mayoría concuerda en que es un estado asociado al envejecimiento y en que, a pesar de la claridad del concepto, el mayor desafío ra- dica en encontrar factores causales. Linda Fried publicó la definición de fragilidad como la presencia de 3 de los siguientes 5 criterios: fatiga crónica autorreferida, debilidad, inactividad, disminución de la velocidad de marcha y pérdida de peso. Este modelo fue replicado y sobre él se construyó el modelo moderno con identificación de factores causales fisiológicos, como activación del sistema de inflamación, alteración del sistema inmunitario, endocrino y musculoesquelético. También se consideran causales ciertas comorbilidades como hipertensión diastólica, ACV, cáncer y EPOC; se asoció asimismo a factores sociodemográficos entre los que se encuentran el sexo femenino y el nivel socioeducativo bajo. Por último se aso- ció discapacidad a fragilidad haciendo hincapié en la superposición de los conceptos discapacidad/fragilidad, dejando en claro que no son sinónimos ni son completamente excluyentes. Se concluye que la fragilidad es un síndrome multifactorial y que la detección de grupos de riesgo constituye el desafío de futuras investigaciones. Palabras clave: fragilidad, factores de riesgo, envejecimiento

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El término fragilidad ha evolucionado a lo largo del tiempo, conceptualizándolo como ¶riesgo§ de morir, de perder funcio- nes, de enfermar, asociado a debilidad, caídas, desnutrición. Distintas definiciones han incluido aspectos físicos, cognitivos y psicosociales. El debate acerca de la definición se centra en si deben o no asociarse factores psicosociales. La mayoría concuerda en que es un estado asociado al envejecimiento y en que, a pesar de la claridad del concepto, el mayor desafío ra- dica en encontrar factores causales. Linda Fried publicó la definición de fragilidad como la presencia de 3 de los siguientes 5 criterios: fatiga crónica autorreferida, debilidad, inactividad, disminución de la velocidad de marcha y pérdida de peso. Este modelo fue replicado y sobre él se construyó el modelo moderno con identificación de factores causales fisiológicos, como activación del sistema de inflamación, alteración del sistema inmunitario, endocrino y musculoesquelético. También se consideran causales ciertas comorbilidades como hipertensión diastólica, ACV, cáncer y EPOC; se asoció asimismo a factores sociodemográficos entre los que se encuentran el sexo femenino y el nivel socioeducativo bajo. Por último se aso- ció discapacidad a fragilidad haciendo hincapié en la superposición de los conceptos discapacidad/fragilidad, dejando en claro que no son sinónimos ni son completamente excluyentes. Se concluye que la fragilidad es un síndrome multifactorial y que la detección de grupos de riesgo constituye el desafío de futuras investigaciones. Palabras clave: fragilidad, factores de riesgo, envejecimiento(AU)

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Gangliocytic paragangliomas are infrequent tumors almost exclusively found in the second portion of the duodenum. An unusual case of a gangliocytic paraganglioma in the third portion of the duodenum with obstructive symptoms is herein reported. A 16-year-old male patient presented with epigastric pain, postprandial plenitude and reflux. A barium swallow failed to demonstrate abnormalities. Endoscopy showed a pedunculated submucosal tumor, originating at the third duodenal portion and causing partial obstruction. Biopsy was not performed due to the risk of bleeding. CT scan demonstrated a polypoid lesion. Through a transmesocolic approach and an anterior duodenotomy, resection of the tumor was performed. No lymph node or other organ affection was found. Histologic examination revealed a gangliocytic paraganglioma. Immunohistochemical examination was performed. Gangliocytic paragangliomas originating in the third or fourth portion of the duodenum, as in the present case, are extremely rare. Characteristic histologic features including epithelioid cells, spindle-shaped cells and ganglion-like cells were met. The majority of cases manifest with a similar benign behavior. Local resection of the tumor is recommended for these cases. An infrequent case of a gangliocytic paraganglioma located in the third portion of the duodenum, with a less common clinical presentation, is herein reported.

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RENAL PHYSIOLOGY IN THE HEALTHY OLDEST OLD HAS THE FOLLOWING CHARACTERISTICS, IN COMPARISON WITH THE RENAL PHYSIOLOGY IN THE YOUNG: a reduced creatinine clearance, tubular pattern of creatinine back-filtration, preserved proximal tubule sodium reabsorption and uric acid secretion, reduced sodium reabsorption in the thick ascending loop of Henle, reduced free water clearance, increased urea excretion, presence of medulla hypotonicity, reduced urinary dilution and concentration capabilities, and finally a reduced collecting tubules response to furosemide which expresses a reduced potassium excretion in this segment due to a sort of aldosterone resistance. All physiological changes of the aged kidney are the same in both genders.