RESUMO

In a cooperative study, four laboratories evaluated the micronucleus test in irradiated and non-irradiated lymphocytes with respect to time of storage, the difference between X-ray and gamma exposure and inter-observer variance. The results were compared with parallel studies on dicentric aberrations. No significant differences between laboratories, with respect to storage time or between gamma and X-irradiation were observed for micronuclei and dicentrics using analysis of variance. However, micronuclei are not suitable for an assessment of exposure inhomogeneity because of a significant overdispersion already in controls and homogeneously irradiated samples.

Assuntos

Preservação de Sangue , Linfócitos/efeitos da radiação , Micronúcleos com Defeito Cromossômico/efeitos da radiação , Bélgica , Preservação de Sangue/estatística & dados numéricos , Chile , Relação Dose-Resposta à Radiação , Humanos , Técnicas In Vitro , Linfócitos/ultraestrutura , Masculino , Testes para Micronúcleos/estatística & dados numéricos , Variações Dependentes do Observador , Fatores de Tempo