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Diagn Microbiol Infect Dis ; 109(2): 116227, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38503028

RESUMO

The objective of this systematic review is to analyze the diagnostic accuracy of rapid dengue diagnostic tests. The search was conducted in the following databases: LILACS, Medline (Pubmed), CRD, The Cochrane Library, Trip Medical Database and Google Scholar. ELISA and PCR assays were adopted as reference methods. Thirty-four articles were included in this systematic review. Receiver operating characteristic (ROC) and Forest Plot were performed to evaluate sensitivity and specificity for each parameter analyzed (NS1, IgM and IgG). The results revealed that the combined analysis of the IgM antibody with the NS1 antigen resulted in greater sensitivity than the isolated analysis of IgM. The three analytes together showed the best performance, with a combined sensitivity of 90 % (95 % CI: 89-92 %) using ELISA as a comparator. Thus, the present review provides relevant knowledge for decision-making between the available rapid diagnostic tests.


Assuntos
Anticorpos Antivirais , Dengue , Imunoglobulina M , Sensibilidade e Especificidade , Humanos , Anticorpos Antivirais/sangue , Cromatografia de Afinidade/métodos , Dengue/diagnóstico , Vírus da Dengue/imunologia , Testes Diagnósticos de Rotina/métodos , Testes Diagnósticos de Rotina/normas , Ensaio de Imunoadsorção Enzimática/métodos , Imunoglobulina G/sangue , Imunoglobulina M/sangue , Curva ROC , Proteínas não Estruturais Virais/imunologia , Proteínas não Estruturais Virais/sangue
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