RESUMO

The present study was undertaken to determine if the serum of a child with severe neutropenia contained antibodies against parental neutrophils. The presence of IgG antibodies to granulocytes from both parents was demonstrated using the indirect immunofluorescence technique. These data suggest an autoimmune etiology for the neutropenia of this patient.

Assuntos

Agranulocitose/etiologia , Autoanticorpos/imunologia , Doenças Autoimunes/etiologia , Neutropenia/etiologia , Neutrófilos/imunologia , Contagem de Células Sanguíneas , Transfusão de Sangue , Transfusão de Eritrócitos , Humanos , Lactente , Masculino , Neutropenia/terapia , Neutrófilos/análise

RESUMO

The present study was undertaken to determine if the serum of a child with severe neutropenia contained antibodies against parental neutrophils. The presence of IgG antibodies to granulocytes from both parents was demonstrated using the indirect immunofluorecence technique. These data suggest an auatoimmune etiology for the neutropenia of this patient

Assuntos

Lactente , Humanos , Autoanticorpos/análise , Neutrófilos/imunologia , Neutropenia/imunologia , Doenças Autoimunes/imunologia , Imunofluorescência , Neutrófilos/análise , Neutropenia/terapia