RESUMO
OBJECTIVE: The objective of this research was to identify and replicate the participation of KLK4 gene polymorphisms in the susceptibility to dental decay. METHODS: A total of 200 patients were recruited using ICDAS criteria - 100 of them with dental caries and 100 with no history of the disease. Buccal cells were collected and the DNA was extracted and amplified using PCR. RESULTS: During the descriptive analysis, the variables ethnicity, biofilm, and gingivitis and the markers rs2242670 and rs2978642 were statistically significant. In the multivariate analysis, the marker rs2242670 and the variable biofilm maintained statistical significance. CONCLUSION: Genetic variations in the KLK4 gene may contribute to dental decay.
Assuntos
Suscetibilidade à Cárie Dentária/genética , Cárie Dentária/genética , Calicreínas/genética , Polimorfismo de Nucleotídeo Único , Adolescente , Adulto , Biofilmes , Brasil/epidemiologia , Criança , Cárie Dentária/epidemiologia , Feminino , Humanos , Masculino , Reação em Cadeia da PolimeraseAssuntos
Butirilcolinesterase/genética , Vitiligo/genética , Adolescente , Adulto , Idade de Início , Brasil , Butirilcolinesterase/metabolismo , Feminino , Estudos de Associação Genética , Humanos , Masculino , Polimorfismo de Nucleotídeo Único , Vitiligo/enzimologia , Vitiligo/etiologia , Adulto JovemRESUMO
The global health scenario shows an epidemic of non-communicable diseases that lead to long-term chronic conditions, some of which are incurable. Many infectious diseases, owing to their development and length, also generate chronic conditions. Similarly, non-morbid states, such as pregnancy, and some life cycles such as adolescence and ageing, follow the same logic. Among all these chronic conditions there is a significant interrelationship with oral health, both in parallel events and common risk factors. This article presents cross-sectional qualitative research into World Health Organisation recommended health policies to address chronic conditions. Several documents published by the organisation were analysed to verify the presence of references to oral health in relation to chronic conditions, particularly cardiovascular diseases and diabetes as these most frequently have oral manifestations. The analysis showed no significant references to oral health or its indicators within the published texts. The study recognises the value of the work developed by the World Health Organisation, as well as its worldwide leadership role in the development of health policies for chronic conditions. This article proposes a coalition of dentistry organisations that could, in a more forceful and collective way, advocate for a greater presence of oral health in drafting policies addressing chronic conditions.