RESUMO
BACKGROUND: the purpose of this study was to investigate the presence of respiratory allergy in 30 Mexican patients bearing cystic fibrosis (CF). METHODS AND RESULTS: all patients completed a clinical history, had a physical examination, total serum IgE, nasal and blood eosinophils determinations and evaluation of skin prick tests for 36 allergens. In 26.6% of the patients included in the study was detected respiratory allergy diagnosed on clinical and laboratory analyses. Skin prick tests of 11 (36.6%) of the patients were positive to at least one allergen and Aspergillus fumigatus (A. fumigatus) was the most frequently observed allergen in 23% of the cases. CONCLUSIONS: we have demonstrated in this study that Mexican patients also present a coexistence of respiratory allergy in patients bearing CF.
Assuntos
Fibrose Cística/complicações , Hipersensibilidade Respiratória/complicações , Adulto , Aspergillus fumigatus/imunologia , Pré-Escolar , Fibrose Cística/imunologia , Feminino , Humanos , Imunoglobulina E/sangue , Lactente , Masculino , México , Hipersensibilidade Respiratória/imunologia , Testes CutâneosRESUMO
OBJECTIVE: During the last decades the impact of pollution in big cities on the upper respiratory tract of children has become an issue of interest. The purpose of the present study was to determine if exposure of healthy children to different concentrations of atmospheric pollution alters morphologically the nasal respiratory epithelium. MATERIAL AND METHODS: In this randomised, prospective, open clinical trial we included 71 healthy children matched for age and sex and divided them into 3 groups: Group I, 31 children from Mexico City. Group II, 21 children from Tula, Hidalgo a moderate polluted area, and Group III, 19 children from Contepec, Michoacán, a rural non-polluted area. We took a nasal biopsy from the lower turbinate and performed nasal cytology in all children. The samples were examined twice by a pathologist with a double-blind technique. Ozone measurements were taken during 1992. RESULTS: Nasal symptoms (nasal obstruction, pruritus and dryness) were present in 96.8%, 71.4% and 52.6% of patients in groups I, II and III respectively (p = 0.001). We also found bilateral hypertrophy turbinates in 100% of children in group I versus 81% and 73% in groups II and III (p = 0.009). Citologic examination disclosed no significant differences among the study groups, although p values were 0.06 respecting inflammation and abnormal goblet cells when we compared group I versus group II and III. Respecting histological examination we found significant differences when comparing group I versus II and III in squamous metaplasia (p = 0.02) and pseudoepitheliomatous hyperplasia (p = 0.003), with not significant differences among keratinization (p = 0.06) and dysplasia (p = 0.06). CONCLUSIONS: The results of this study indicate that exposure to a polluted atmosphere is followed by severe changes in the histology and cytology of the nasal mucosa in healthy children, with these changes being more frequent and severe in the more polluted areas. These findings implicate that we must put more attention on the long term effects of atmospheric pollution in order to establish stronger control measures.
Assuntos
Poluição do Ar/efeitos adversos , Mucosa Nasal/patologia , Obstrução Nasal/patologia , Rinite/patologia , Adolescente , Poluentes Atmosféricos/efeitos adversos , Biópsia , Criança , Método Duplo-Cego , Feminino , Humanos , Hipertrofia , Masculino , Metaplasia , México , Ozônio/efeitos adversos , Estudos Prospectivos , População Rural , Conchas Nasais/patologia , População UrbanaRESUMO
Clonal studies define the proteic sequence of several allergens leading to the recombination and the use of them for immunotherapy extracts. It has been possible to clone the receptors for IgE in basophils and mast cells and the regulation mechanisms had been delucidated. In a near future it will be possible to design recombinant molecules for the specific inhibition of synthesis and receptors of IgE and avoid the signal transmissions and the release of mediators. The diagnosis of several diseases is based in molecular techniques, inclusive in uterus. Genes for various diseases had been cloned in immunology; recombinations with gamma interferon had been used for treatment of subjects with atopic dermatitis and chronic granulomatous disease.
Assuntos
Biologia Molecular/métodos , Humanos , Hipersensibilidade/diagnóstico , Hipersensibilidade/terapia , Doenças do Sistema Imunitário/diagnóstico , Doenças do Sistema Imunitário/terapiaRESUMO
Study made with 45 patients in the allergy service of the Instituto Nacional de Pediatría, with the purpose of analyzing the virus participation in the precipitation of asthmatic crisis in children who lived in the southeast of Mexico City. The subjects were included in the study if they presented signs of atopy or infection of the superior air channels. Pollen allergics, rhinosinusitis, smokers relatives and patients who own pets were excluded. In this population group, the participation of the virus were RSV, influenza B and parainfluenza.
Assuntos
Asma/etiologia , Infecções Respiratórias/complicações , Viroses/complicações , Adolescente , Anticorpos Antivirais/sangue , Asma/epidemiologia , Estudos de Casos e Controles , Criança , Pré-Escolar , Testes de Fixação de Complemento , Citocinas/fisiologia , Eicosanoides/fisiologia , Feminino , Humanos , Incidência , Vírus da Influenza B/imunologia , Masculino , México/epidemiologia , Vírus da Parainfluenza 1 Humana/imunologia , Vírus Sinciciais Respiratórios/imunologia , Infecções Respiratórias/epidemiologia , Infecções Respiratórias/virologia , Estudos Soroepidemiológicos , População Urbana , Viroses/epidemiologiaRESUMO
This article review the effects of neuropeptides in the pathogenesis of Asthma. It is a review of literature and show most important neuropeptides, physical and chemical characteristics effects and some clinical studies about them.
Assuntos
Asma/etiologia , Asma/fisiopatologia , Neuropeptídeos/fisiologia , Sistema Nervoso Autônomo/fisiopatologia , Peptídeo Relacionado com Gene de Calcitonina/fisiologia , Humanos , Neuropeptídeo Y/fisiologia , Peptídeo PHI/fisiologia , Substância P/fisiologia , Peptídeo Intestinal Vasoativo/fisiologiaRESUMO
We studied 40 children with one o more perennial allergic diseases (bronchial asthma, allergic rhinitis, and/or atopic dermatitis) to assess the value in our country of in vivo and in vitro tests more frequently used in the diagnosis of allergy, such as total serum IgE, specific allergen IgE (RAST) and prick skin test in patients sensitives to D. pteronissinus, D. farinae or both. All patients had positive prick skin tests. Total serous IgE was elevated in 95% of cases with poor correlation coefficient (r) between prick skin test reactivity and total serous IgE concentration with no statistical significance. On the other hand, 95% of patients showed a positive RAST with a correlation coefficient of 0.31 (p less than 0.05). We concluded that in our country clinical history and prick skin tests are sufficiently accurate in a reasonable way to make a diagnosis of allergic etiology in patients sensitives to mites of the house dust.
Assuntos
Ácaros e Carrapatos , Hipersensibilidade/diagnóstico , Animais , Criança , Feminino , Humanos , Hipersensibilidade/sangue , Imunoglobulina E/sangue , Masculino , Teste de Radioalergoadsorção , Testes CutâneosRESUMO
This study included the review of 1000 clinical histories of allergic diseases, in a retrospective way, that was seeing in the Service of Allergy of the Instituto Nacional de Pediatría in Mexico city. All the patients were previously diagnosed with several allergic pathologiest like: bronchial asthma, rhinitis, asthma and rhinitis, atopic dermatitis, etc. All the patients received as main therapeutic treatment ketotifen at least during 3 months to 12 months. Global improvement in all patients with the use of ketotifen, reach 84%, including all the pathologiest studied. The tolerance of the drug specially in children was very good.
Assuntos
Hipersensibilidade/tratamento farmacológico , Cetotifeno/uso terapêutico , Adolescente , Asma/tratamento farmacológico , Criança , Pré-Escolar , Dermatite Atópica/tratamento farmacológico , Feminino , Humanos , Hipersensibilidade/epidemiologia , Lactente , Masculino , México/epidemiologia , Estudos Retrospectivos , Rinite/tratamento farmacológicoRESUMO
Concentrations of total serum IgE were measured by an immunoenzymatic assay (Phadezym-PRIST) in 60 mexican onchocerciasis patients. In order to detect IgE antibodies against adult Onchocerca volvulus antigens, separately six onchocerciasis sera were depleted of IgE antibodies by using a mixture of Onchocerca gutturosa, Ascaris suum and Fasciola hepatica antigenic extracts coupled with sepharose 4B. Additionally, the sera were incubated with an adult O. volvulus antigenic extract coupled with sepharose 4B. The differences found between the IgE levels before and after incubation with heterologous antigens show that the median IgE value against O. volvulus adults antigens varies between 20 and 65 percent of the total serum IgE.
Assuntos
Anticorpos Anti-Helmínticos/análise , Imunoglobulina E/análise , Oncocercose/imunologia , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Técnicas Imunoenzimáticas , Masculino , MéxicoRESUMO
In order to determine whether an elevation of the IgE serum level exist in children with invasive amebiasis when compared with a control group, a prospective, observational and descriptive study was performed on 20 patients from the problem group and 21 from a control group, where the possibility of other causes which could raise the IgE levels were dismissed. This antibody was measured in serum and compared with the reported levels of mexican and foreign populations. A notable elevation of the IgE level was found in the studied groups, without any significant differences between them. It wasn't demonstrated that the serum level is as high as immunological response against E. histolytica.